DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Amy-p and amy2al2

DIOPT Version :9

Sequence 1:	NP_001286518.1	Gene:	Amy-p / 47764	FlyBaseID:	FBgn0000079	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_001003729.1	Gene:	amy2al2 / 445049	ZFINID:	ZDB-GENE-040801-179	Length:	512	Species:	Danio rerio

Alignment Length:	511	Identity:	277/511 - (54%)
Similarity:	347/511 - (67%)	Gaps:	25/511 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 IVCLALLAVANAQFDTNYASGRSGMVHLFEWKWDDIAAECENFLGPNGYAGVQVSPVNENA--VK 69
            :|.:|:..:..||.:.|..:||:.:||||||:|.|||.|||.:|.||||.|||:||.:|:.  ..
Zfish     4 LVLVAIFGLGFAQHNPNTKNGRTSIVHLFEWRWADIAEECERYLAPNGYGGVQISPPSEHVKLTN 68

  Fly    70 DSRPWWERYQPISYKLETRSGNEEQFASMVKRCNAVGVRTYVDVVFNHMAAD---GGTYGTGGST 131
            ...|||:|||||||.|.:|||.|.:...|:.|||.|||..|.|||.|||...   .||..:.||.
Zfish    69 PWHPWWQRYQPISYNLCSRSGTEAELKDMITRCNNVGVNIYADVVINHMCKSIHGAGTPSSCGSH 133

  Fly   132 ASPSSKSYPGVPYSSLDFNP-TC-----AISNYNDANEVRNCELVGLRDLNQGNSYVQDKVVEFL 190
            ...:.:.:|.||||.||||. .|     .|.:|||..:||:|.|..|.||.....||:.||.|:|
Zfish   134 FDANKEDFPTVPYSYLDFNDGKCKSASGQIESYNDIYQVRDCRLEDLLDLALEKDYVRGKVAEYL 198

  Fly   191 DHLIDLGVAGFRVDAAKHMWPADLAVIYGRLKNLNTDHGFASGSKAYIVQEVIDMGGEAISKSEY 255
            :.||:||||||||||.|||||.||:.:|.|||.||| ..|.||:|.:|.|||||:|||.|..|||
Zfish   199 NKLIELGVAGFRVDACKHMWPGDLSNVYSRLKTLNT-KWFPSGTKPFIYQEVIDLGGEPIKASEY 262

  Fly   256 TGLGAITEFRHSDSIGKVFRGKD--QLQYLTNWGTAWGFAASDRSLVFVDNHDNQRGHGAGGADV 318
            .||..:|||:||..||...|..|  :|.||.|||..|||..||::||||||||||||||||||.|
Zfish   263 YGLARVTEFKHSAKIGTAVRKWDGEKLSYLKNWGEGWGFMPSDKALVFVDNHDNQRGHGAGGASV 327

  Fly   319 LTYKVPKQYKMASAFMLAHPFGTPRVMSSFSF--------TDTD-QGPPT-TDGHNIASPIFNSD 373
            ||:...:.||||:.||||||:|..|||||:.:        .:.| .|||: :||.....|| |.|
Zfish   328 LTFWDSRLYKMAAGFMLAHPYGVTRVMSSYQWDRKIVNGKDENDWMGPPSFSDGSTKPVPI-NPD 391

  Fly   374 NSCSGGWVCEHRWRQIYNMVAFRNTVGLDEIQNWWDNGSNQISFSRGSRGFVAFNNDNYDLNSSL 438
            ::|..|||||||||||.|||.|||.|....:.||||||::||:|||||:||:..||||::||::|
Zfish   392 STCGDGWVCEHRWRQIRNMVIFRNVVNGQPLFNWWDNGNSQIAFSRGSKGFIVINNDNWELNATL 456

  Fly   439 QTGLPAGTYCDVISGSKSGSSCTGKTVTVGSDGRASIYIGSSEDDGVLAIHVNAKL 494
            .|||.:|||||:|||.|||:|||||.|:|.|||:|:..|..:|:|..:|||.::||
Zfish   457 NTGLQSGTYCDIISGEKSGNSCTGKQVSVDSDGKATFSISHTEEDPFMAIHADSKL 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Amy-p	NP_001286518.1	AmyAc_bac_euk_AmyA	28..399	CDD:200456	215/393 (55%)
		Alpha-amylase	54..342	CDD:278554	165/300 (55%)
		Aamy_C	405..493	CDD:214749	53/87 (61%)
amy2al2	NP_001003729.1	AmyAc_bac_euk_AmyA	25..417	CDD:200456	215/393 (55%)
amy2al2	NP_001003729.1	Aamy_C	424..511	CDD:214749	53/86 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576491
Domainoid	1	1.000	269	1.000	Domainoid score	I1797
eggNOG	1	0.900	-	-		E1_COG0366
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	577	1.000	Inparanoid score	I1002
OMA	1	1.010	-	-		QHG53143
OrthoDB	1	1.010	-	-		D231864at33208
OrthoFinder	1	1.000	-	-		FOG0000926
OrthoInspector	1	1.000	-	-		mtm6522
orthoMCL	1	0.900	-	-		OOG6_103366
Panther	1	1.100	-	-	O	PTHR43447
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X338
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.770