DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Amy-p and mde5

DIOPT Version :9

Sequence 1:	NP_001286518.1	Gene:	Amy-p / 47764	FlyBaseID:	FBgn0000079	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_001343001.1	Gene:	mde5 / 3361499	PomBaseID:	SPAC25H1.09	Length:	513	Species:	Schizosaccharomyces pombe

Alignment Length:	326	Identity:	70/326 - (21%)
Similarity:	118/326 - (36%)	Gaps:	92/326 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 DTNYASGRSGMVHLFEWKWDDIAAECENFLGPNGYAGVQVSPVNENAVKDSRPWWERY-----QP 80
            |..|..|          .|..|..:.:...| .|:..:.:||:.:| ::....:.|.|     |.
pombe    56 DREYCGG----------NWRGIIDKLDYIQG-MGFTAIWISPIIKN-IEGRTKYGEAYHGYWPQD 108

  Fly    81 ISYKLETRSGNEEQFASMVKRCNAVGVRTYVDVVFNHMAADGGTYGTGGSTASPSSKSYPGV--P 143
            : |.|....|.|:....:....:..|:...||.|.|||           .::.|.:..| |:  |
pombe   109 L-YTLNPHFGTEQDLIDLADALHDRGMYLMVDTVVNHM-----------GSSDPRNIDY-GIYRP 160

  Fly   144 YS-SLDFNPTCAISNYNDANEVRNC----ELVGLRDLNQGNSYVQDKVVEFL-DHLIDLGVAGFR 202
            :: |..::|.|.|.. :....:..|    |.:.|.|::..|..:.:.:..|: |.:....:.|.|
pombe   161 FNQSSHYHPMCPIEQ-DKPLSLEQCWIGTEDMTLPDIDTENPQIIETLYNFIHDQVKQFKIDGLR 224

  Fly   203 VDAAKHM----WP--ADLAVIY-------GRLKNLNTDHGFASGSKAYIVQ-----EVIDMGGEA 249
            |||.||:    ||  .:.|.:|       |:.........:..|...:.||     .||.:...|
pombe   225 VDATKHVRRTFWPGFCESAGVYCQGEEWTGQADLFCEWQEYMDGLHNFPVQGVAAESVIPLNDRA 289

  Fly   250 ISK----------------------------------SEYTGL-GAITEFRHSDSIGKVFRGKDQ 279
            :.|                                  ::||.| .|:|....||.|..||.|::|
pombe   290 LRKTAIAMNLVAHHCKDSTLLGLFLESQDAPRLAALNNDYTVLKNAMTLNLMSDGIPIVFYGQEQ 354

  Fly   280 L 280
            :
pombe   355 M 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Amy-p	NP_001286518.1	AmyAc_bac_euk_AmyA	28..399	CDD:200456	67/319 (21%)
		Alpha-amylase	54..342	CDD:278554	64/293 (22%)
		Aamy_C	405..493	CDD:214749
mde5	NP_001343001.1	AmyAc_euk_AmyA	26..396	CDD:200458	70/326 (21%)
mde5	NP_001343001.1	DUF1966	410..488	CDD:312682
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0366
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4468
SonicParanoid	1	1.000	-	-		X338
TreeFam	0	0.000	Not matched by this tool.
	4	3.840