DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Amy-p and Amy1a

DIOPT Version :9

Sequence 1:	NP_001286518.1	Gene:	Amy-p / 47764	FlyBaseID:	FBgn0000079	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_001010970.1	Gene:	Amy1a / 24203	RGDID:	2113	Length:	521	Species:	Rattus norvegicus

Alignment Length:	512	Identity:	286/512 - (55%)
Similarity:	358/512 - (69%)	Gaps:	24/512 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KSIVCLALLAVANAQFDTNYASGRSGMVHLFEWKWDDIAAECENFLGPNGYAGVQVSPVNENAVK 69
            |..:.|:|:.:..||:|.:...|||.:||||||:|.|||.|||.:|.|||:.||||||.|||.|.
  Rat    12 KFFLLLSLIGLCWAQYDPHTFYGRSSIVHLFEWRWVDIAKECERYLAPNGFGGVQVSPPNENIVV 76

  Fly    70 DS--RPWWERYQPISYKLETRSGNEEQFASMVKRCNAVGVRTYVDVVFNHM---AADGGTYGTGG 129
            :|  |||||||||||||:.:|||||::|..||.|||.||||.|||.|.|||   .|:.|...|.|
  Rat    77 NSPFRPWWERYQPISYKICSRSGNEDEFRDMVNRCNNVGVRIYVDAVINHMCGVGAEAGQSSTCG 141

  Fly   130 STASPSSKSYPGVPYSSLDFNP-TC-----AISNYNDANEVRNCELVGLRDLNQGNSYVQDKVVE 188
            |..:|:::.:||||||..|||. .|     .|.|||||.:||:|.|.||.||.....||:.||.:
  Rat   142 SYFNPNNRDFPGVPYSGFDFNDGKCKTGSGGIENYNDAAQVRDCRLSGLLDLALEKDYVRTKVAD 206

  Fly   189 FLDHLIDLGVAGFRVDAAKHMWPADLAVIYGRLKNLNTDHGFASGSKAYIVQEVIDMGGEAISKS 253
            :::||||:||||||:||:|||||.|:..:..:|.|||| ..|:.|||.:|.|||||:||||:|.:
  Rat   207 YMNHLIDIGVAGFRLDASKHMWPGDIKAVLDKLHNLNT-KWFSEGSKPFIYQEVIDLGGEAVSSN 270

  Fly   254 EYTGLGAITEFRHSDSIGKVFRGKD--QLQYLTNWGTAWGFAASDRSLVFVDNHDNQRGHGAGGA 316
            ||.|.|.:|||::...:|||.|..|  ::.||.|||..|||..|||:|||||||||||||||||:
  Rat   271 EYFGNGRVTEFKYGAKLGKVLRKWDGEKMAYLKNWGEGWGFMPSDRALVFVDNHDNQRGHGAGGS 335

  Fly   317 DVLTYKVPKQYKMASAFMLAHPFGTPRVMSSFSF-------TDTDQ--GPPTTDGHNIASPIFNS 372
            .:||:...:.||||..||||||:|..||||||.:       .|.:.  |||..:|......| ||
  Rat   336 SILTFWDARLYKMAVGFMLAHPYGFTRVMSSFHWPRYFENGKDVNDWVGPPNNNGATKEVTI-NS 399

  Fly   373 DNSCSGGWVCEHRWRQIYNMVAFRNTVGLDEIQNWWDNGSNQISFSRGSRGFVAFNNDNYDLNSS 437
            |::|...||||||||||.|||||||.|......|||||||||::|.||::||:.||||::||:::
  Rat   400 DSTCGNDWVCEHRWRQIRNMVAFRNVVNGQPFANWWDNGSNQVAFGRGNKGFIVFNNDDWDLSTT 464

  Fly   438 LQTGLPAGTYCDVISGSKSGSSCTGKTVTVGSDGRASIYIGSSEDDGVLAIHVNAKL 494
            ||||||||||||||||.|...:|||..|.|||||.|...|.:|.:|..:||||.:|:
  Rat   465 LQTGLPAGTYCDVISGDKVDGNCTGIKVYVGSDGNAYFSISNSAEDPFIAIHVESKI 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Amy-p	NP_001286518.1	AmyAc_bac_euk_AmyA	28..399	CDD:200456	223/392 (57%)
		Alpha-amylase	54..342	CDD:278554	172/300 (57%)
		Aamy_C	405..493	CDD:214749	54/87 (62%)
Amy1a	NP_001010970.1	AmyAc_bac_euk_AmyA	35..426	CDD:200456	223/392 (57%)
		AmyA	56..>325	CDD:223443	151/269 (56%)
		Aamy_C	432..520	CDD:214749	54/87 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337356
Domainoid	1	1.000	273	1.000	Domainoid score	I1716
eggNOG	1	0.900	-	-		E1_COG0366
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	576	1.000	Inparanoid score	I1004
OMA	1	1.010	-	-		QHG53143
OrthoDB	1	1.010	-	-		D231864at33208
OrthoFinder	1	1.000	-	-		FOG0000926
OrthoInspector	1	1.000	-	-		mtm8995
orthoMCL	1	0.900	-	-		OOG6_103366
Panther	1	1.100	-	-	O	PTHR43447
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X338
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.770