Protein Alignment Abd-B and Hoxb13

DIOPT Version :10

• Sequence 1: NP_524896.2
• Gene: Abd-B / 47763
• FlyBaseID: FBgn0000015
• Length: 493
• Species: Drosophila melanogaster
• Sequence 2: NP_032293.1
• Gene: Hoxb13 / 15408
• MGIID: 107730
• Length: 286
• Species: Mus musculus
• Alignment Length: 271
• Identity: 70/271 - (25%)
• Similarity: 97/271 - (35%)
• Gaps: 92/271 - (33%)

  Fly   225 SIQLAPLHIPA-------IRAGPGFETDTSAAVKRHTAHWAYNDEGFNQHYGSGYYDRK------ 276
            ::..|||.:|.       ....||.....|.|    ...:.|        :|.|||..:
Mouse    46 TVNYAPLDLPGSAEPPKQCHPCPGVPQGASPA----PVPYGY--------FGGGYYSCRVSRSSL 98

  Fly   277 -------HMFAYPYPETQFPVGQYWGPNYRPDQTTSAAAAAAYMNEAERHVSAAARQSVEGTSTS 334
                   .:..|| .||..|..:|      |.:.|..|....|                    ..
Mouse    99 KPCAQTAALATYP-SETPAPGEEY------PSRPTEFAFYPGY--------------------PG 136

  Fly   335 SYEP----------PTYSSPGGLRG---YPSENYSSSGASGGLS-----VGAVGPCTPNPGLHEW 381
            .|:|          .|..:||..|.   .|.::|.....:||.:     .|...|  |.|.....
Mouse   137 PYQPMASYLDVSVVQTLGAPGEPRHDSLLPVDSYQPWALAGGWNSQMCCQGEQNP--PGPFWKAA 199

  Fly   382 TGQVSV-------------RKKRKPYSKFQTLELEKEFLFNAYVSKQKRWELARNLQLTERQVKI 433
            ..:.||             ||||.||||.|..|||:|:..|.:::|.||.:::....|:|||:.|
Mouse   200 FAEPSVQHPPPDGCAFRRGRKKRIPYSKGQLRELEREYAANKFITKDKRRKISAATSLSERQITI 264

  Fly   434 WFQNRRMKNKK 444
            ||||||:|.||
Mouse   265 WFQNRRVKEKK 275

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Abd-B	NP_524896.2	Homeodomain	388..444	CDD:459649	29/55 (53%)
Hoxb13	NP_032293.1	HoxA13_N	12..124	CDD:463521	20/96 (21%)
		Homeodomain	219..275	CDD:459649	29/55 (53%)
		Interaction with DNA. /evidence=ECO:0000250|UniProtKB:Q92826	219..248		15/28 (54%)
		Interaction with 5-mCpG DNA. /evidence=ECO:0000250|UniProtKB:Q92826	260..275		10/14 (71%)
		Interaction with DNA. /evidence=ECO:0000250|UniProtKB:Q92826	272..275		1/2 (50%)