DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fkbp59 and Fkbp6

DIOPT Version :9

Sequence 1:	NP_001285784.1	Gene:	Fkbp59 / 47762	FlyBaseID:	FBgn0029174	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	XP_030110810.1	Gene:	Fkbp6 / 94244	MGIID:	2137612	Length:	363	Species:	Mus musculus

Alignment Length:	394	Identity:	91/394 - (23%)
Similarity:	152/394 - (38%)	Gaps:	115/394 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 IDLSGDGGVLKEILKEGTG-TETPHSGCTVSLHYTGRL--VDGTEFDSSLSRNEPFEFSLGKGNV 68
            :|:|||.||||:|::|||| |.||.:  :|.:.|:|.|  :| ..|||:..|..|....||:...
Mouse    66 LDISGDRGVLKDIIREGTGDTVTPDA--SVLVKYSGYLEHMD-KPFDSNCFRKTPRLMKLGEDIT 127

  Fly    69 IKAFDMGVATMKLGERCFLTCAPNYAYGAAGSPPAIPPDATLIFELEMLGWKGEDLSPNQDGSID 133
            :...::|:.:|:.||.......|.||||..|.||.|||:||::||:|:
Mouse   128 LWGMELGLLSMRKGELARFLFKPAYAYGTLGCPPLIPPNATVLFEIEL----------------- 175

  Fly   134 RTILEASDKKRTPSDGAFVKAHISGSFEGRVFEDRDVEFDYGEGKAIGIIDGVEIALEKMNVGET 198
                                                          |..:|..|
Mouse   176 ----------------------------------------------IDFLDSAE----------- 183

  Fly   199 SRIKIQAKY-AFGAKGNEEFKIPPNATVEYTVKLVDCGKGLEEWKLSDEERLAEAKVYKEKGTNY 262
                 ..|: |..|:..|:|.:                          ::.|..|...:|.|...
Mouse   184 -----SDKFCALSAEQQEQFPL--------------------------QKVLKVAATEREFGNYL 217

  Fly   263 FKKENWALAIKMYTKCKNILPTTVHTNEE---VKKIKVATHSNIALCHQKSNDHFEAKQECNEVL 324
            |::..:..|...|.:...:|...:.|.||   |:...:....|::..:.|.:....|.:...:.|
Mouse   218 FRQNRFCDAKVRYKRALLLLHRRLATCEEQHLVEPAVLLVLLNLSFVYLKLDRPAMALRYGEQAL 282

  Fly   325 ALDKNNVKALYRRGQCNLTINELEDALEDFQKVIQLEPGNKAAANQVIICKQKLKESKNKEKKLY 389
            .:||.|.|||:|.||..|.:.|.|.|.:...:..:.:|.|....|::.......::..::|:::.
Mouse   283 LIDKRNAKALFRCGQACLLLTEYERARDFLVRAQKEQPCNHDINNELKKLSSHYRDYVDREREMC 347

  Fly   390 ANMF 393
            ..||
Mouse   348 HRMF 351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fkbp59	NP_001285784.1	FKBP_C	25..117	CDD:278674	36/94 (38%)
		ppisom_GldI	<124..233	CDD:132555	8/109 (7%)
		BamD	252..>390	CDD:276939	32/140 (23%)
		TPR_12	252..329	CDD:290160	16/79 (20%)
		TPR repeat	252..280	CDD:276939	6/27 (22%)
		TPR repeat	252..280	CDD:276809	6/27 (22%)
		TPR repeat	287..326	CDD:276939	8/41 (20%)
		TPR repeat	296..326	CDD:276809	4/29 (14%)
		TPR_11	299..362	CDD:290150	17/62 (27%)
		TPR repeat	329..361	CDD:276939	11/31 (35%)
		TPR_1	331..364	CDD:278916	11/32 (34%)
		TPR repeat	331..359	CDD:276809	10/27 (37%)
Fkbp6	XP_030110810.1	FKBP_C	86..176	CDD:365980	35/155 (23%)
		TPR_12	254..315	CDD:315987	17/60 (28%)
		TPR repeat	254..284	CDD:276809	4/29 (14%)
		TPR repeat	289..317	CDD:276809	10/27 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0545
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810