DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fkbp59 and FKBP6

DIOPT Version :9

Sequence 1:	NP_001285784.1	Gene:	Fkbp59 / 47762	FlyBaseID:	FBgn0029174	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_003593.3	Gene:	FKBP6 / 8468	HGNCID:	3722	Length:	327	Species:	Homo sapiens

Alignment Length:	397	Identity:	91/397 - (22%)
Similarity:	153/397 - (38%)	Gaps:	121/397 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 IDLSGDGGVLKEILKEGTGTETPHSGCTVSLHYTGRL--VDGTEFDSSLSRNEPFEFSLGKGNVI 69
            :|:|||.||||::::||.| :......:|.:.|:|.|  :| ..|||:..|..|....||:...:
Human    30 LDISGDRGVLKDVIREGAG-DLVAPDASVLVKYSGYLEHMD-RPFDSNYFRKTPRLMKLGEDITL 92

  Fly    70 KAFDMGVATMKLGERCFLTCAPNYAYGAAGSPPAIPPDATLIFELEMLGWKGEDLSPNQDGSIDR 134
            ...::|:.:|:.||.......||||||..|.||.|||:.|::||:|:|.
Human    93 WGMELGLLSMRRGELARFLFKPNYAYGTLGCPPLIPPNTTVLFEIELLD---------------- 141

  Fly   135 TILEASDKKRTPSDGAFVKAHISGSFEGRVFEDRDVEFDYGEGKAIGIIDGVEIALEK-MNVGET 198
                            |:....|..|.....|.:|                 :..|:| :.|..|
Human   142 ----------------FLDCAESDKFCALSAEQQD-----------------QFPLQKVLKVAAT 173

  Fly   199 SRIKIQAKYAFGAKGNEEFKIPPNATVEYTVKLVDCGKGLEEWKLSDEERLAEAKVYKEKGTNYF 263
            .|          ..||..|:                           :.|..:|||..::.....
Human   174 ER----------EFGNYLFR---------------------------QNRFYDAKVRYKRALLLL 201

  Fly   264 KK-------ENWALAIKMYTKCKNILPTTVHTNEEVKKIKVATHSNIALCHQKSNDHFEAKQECN 321
            ::       ::...|.|        ||..::.:....|:...|   ||||:.:
Human   202 RRRSAPPEEQHLVEAAK--------LPVLLNLSFTYLKLDRPT---IALCYGE------------ 243

  Fly   322 EVLALDKNNVKALYRRGQCNLTINELEDALEDFQKVIQLEPGNKAAANQVIICKQKLKESKNKEK 386
            :.|.:|:.|.|||:|.||..|.:.|.:.|.:...:..:.:|.|....|::.......::..:|||
Human   244 QALIIDQKNAKALFRCGQACLLLTEYQKARDFLVRAQKEQPFNHDINNELKKLASCYRDYVDKEK 308

  Fly   387 KLYANMF 393
            :::..||
Human   309 EMWHRMF 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fkbp59	NP_001285784.1	FKBP_C	25..117	CDD:278674	33/93 (35%)
		ppisom_GldI	<124..233	CDD:132555	13/109 (12%)
		BamD	252..>390	CDD:276939	31/144 (22%)
		TPR_12	252..329	CDD:290160	15/83 (18%)
		TPR repeat	252..280	CDD:276939	5/34 (15%)
		TPR repeat	252..280	CDD:276809	5/34 (15%)
		TPR repeat	287..326	CDD:276939	7/38 (18%)
		TPR repeat	296..326	CDD:276809	6/29 (21%)
		TPR_11	299..362	CDD:290150	17/62 (27%)
		TPR repeat	329..361	CDD:276939	10/31 (32%)
		TPR_1	331..364	CDD:278916	10/32 (31%)
		TPR repeat	331..359	CDD:276809	9/27 (33%)
FKBP6	NP_003593.3	FKBP_C	51..140	CDD:306713	32/89 (36%)
		TPR	<164..315	CDD:223533	40/210 (19%)
		TPR 1	171..204		9/69 (13%)
		TPR 2	219..252		10/47 (21%)
		TPR repeat	221..247	CDD:276809	6/40 (15%)
		TPR repeat	252..282	CDD:276809	10/29 (34%)
		TPR 3	253..286		10/32 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0545
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810