DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fkbp59 and TWD1

DIOPT Version :9

Sequence 1:	NP_001285784.1	Gene:	Fkbp59 / 47762	FlyBaseID:	FBgn0029174	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_188801.2	Gene:	TWD1 / 821718	AraportID:	AT3G21640	Length:	365	Species:	Arabidopsis thaliana

Alignment Length:	411	Identity:	103/411 - (25%)
Similarity:	152/411 - (36%)	Gaps:	137/411 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 EGN---KIDLSG---DGGVLKEILKEGTGTETPHSGCTVSLHYTGRLVDGT-EFDSSLSRNEPFE 60
            |||   |:|...   |..|.|:|:|||.|:: |....|..|||.....:.. :|:.:....:|.|
plant    33 EGNVPPKVDSEAEVLDEKVSKQIIKEGHGSK-PSKYSTCFLHYRAWTKNSQHKFEDTWHEQQPIE 96

  Fly    61 FSLGK-GNVIKAFDMGVATMKLGERCFLTCAPNYAYGAAG--SPPAIPPDATLIFELEMLGWKGE 122
            ..||| ...:....:|||:||.|||..:......|||..|  |.|.:||.|.|::|:|::|:
plant    97 LVLGKEKKELAGLAIGVASMKSGERALVHVGWELAYGKEGNFSFPNVPPMADLLYEVEVIGF--- 158

  Fly   123 DLSPNQDGSIDRTILEASDKKRTPSDGAFVKAHISGSFEGRVFEDRDVEFDYGEGKAIGIIDGVE 187
                      |.|                        .||:...|..||
plant   159 ----------DET------------------------KEGKARSDMTVE---------------- 173

  Fly   188 IALEKMNVGETSRIKIQAKYAFGAKGNEEFKIPPNATVEYTVKLVDCGKGLEEWKLSDEERLAEA 252
                 ..:|...|.|:.        ||..||                           ||:|.||
plant   174 -----ERIGAADRRKMD--------GNSLFK---------------------------EEKLEEA 198

  Fly   253 KVYKEKGTNYF----------KKENWALAIKMYTKCKNILPTTVHTNEEVKKIKVATHSNIALCH 307
            ....|....|.          |.::.|||:|  ..|                     |.|||.|.
plant   199 MQQYEMAIAYMGDDFMFQLYGKYQDMALAVK--NPC---------------------HLNIAACL 240

  Fly   308 QKSNDHFEAKQECNEVLALDKNNVKALYRRGQCNLTINELEDALEDFQKVIQLEPGNKAAANQVI 372
            .|...:.||...||.||..::.|.|||:|||:....:.:::.|.:||:|..:..|.:||...::.
plant   241 IKLKRYDEAIGHCNIVLTEEEKNPKALFRRGKAKAELGQMDSARDDFRKAQKYAPDDKAIRRELR 305

  Fly   373 ICKQKLKESKNKEKKLYANMF 393
            ...::.|....|:|::|..:|
plant   306 ALAEQEKALYQKQKEMYKGIF 326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fkbp59	NP_001285784.1	FKBP_C	25..117	CDD:278674	32/95 (34%)
		ppisom_GldI	<124..233	CDD:132555	14/108 (13%)
		BamD	252..>390	CDD:276939	38/147 (26%)
		TPR_12	252..329	CDD:290160	21/86 (24%)
		TPR repeat	252..280	CDD:276939	9/37 (24%)
		TPR repeat	252..280	CDD:276809	9/37 (24%)
		TPR repeat	287..326	CDD:276939	12/38 (32%)
		TPR repeat	296..326	CDD:276809	12/29 (41%)
		TPR_11	299..362	CDD:290150	23/62 (37%)
		TPR repeat	329..361	CDD:276939	11/31 (35%)
		TPR_1	331..364	CDD:278916	11/32 (34%)
		TPR repeat	331..359	CDD:276809	10/27 (37%)
TWD1	NP_188801.2	FKBP_C	62..156	CDD:395196	31/94 (33%)
		PRK15331	196..310	CDD:357168	36/136 (26%)
		TPR repeat	230..259	CDD:276809	13/49 (27%)
		TPR repeat	264..292	CDD:276809	10/27 (37%)
		TPR repeat	298..323	CDD:276809	5/24 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	59	1.000	Domainoid score	I3893
eggNOG	1	0.900	-	-		E1_COG0545
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D897391at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820