DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fkbp59 and fkbp16

DIOPT Version :9

Sequence 1:	NP_001285784.1	Gene:	Fkbp59 / 47762	FlyBaseID:	FBgn0029174	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_001373781.1	Gene:	fkbp16 / 497400	ZFINID:	ZDB-GENE-050208-116	Length:	504	Species:	Danio rerio

Alignment Length:	328	Identity:	91/328 - (27%)
Similarity:	154/328 - (46%)	Gaps:	34/328 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 DATLIFELEMLGW---KGEDL-------SPNQDGSIDRTILEAS-DKKRTPSDGAFVKAHISGSF 160
            |.||..:.:|..|   :.|:|       :...|..:.:.:|:|. :...||:.|..|...:.|..
Zfish   154 DDTLFPDFDMEEWTTSRFEELFLADDWKNITDDCLLKKKVLQAGPENALTPAWGQEVTLKMQGVL 218

  Fly   161 EGRVFEDRD--VEFDYGEGKAIGIIDGVEIALEKMNVGETSRIKIQAKYAFGAKGNEEFKIPPNA 223
            |.|...::|  :.|..|||.....::...|.::|   ||.:.:...::|.:|..|.|. .||..|
Zfish   219 EDRTVVEKDSKLVFIIGEGDVTQALEECAITMKK---GEIALLLADSQYTYGLLGREP-DIPAWA 279

  Fly   224 TVEYTVKLVDCGKGLEEWKLSDEERLAEAKVYKEKGTNYFKKENWALAIKMYTKCKNILPTTVHT 288
            .:.|.::|:|..:..:...|...:|:......:|:|..||::|.::.|::.|....::|  |..|
Zfish   280 PLLYQLQLLDFREKPDPLLLPVPDRIRIGNQKRERGNFYFQREEFSKAVQAYCMALDVL--TTRT 342

  Fly   289 N----------EEVKKIKVATHSNIALCHQKSNDHFEAKQECNEVLALDKNNVKALYRRGQCNLT 343
            |          |||...:|...:|:|....|.....||.....:||.||..|||||:|:|:....
Zfish   343 NDGQNCVAEEEEEVNDYRVKCLNNLAAAQLKLGHFDEALHTSQDVLFLDPQNVKALFRKGKLLSD 407

  Fly   344 INELEDALEDFQKVIQLEPGNKA--AANQVIICKQK-LKESKNKEKKLYANMFTKLAANDKETEP 405
            ..|.|:|:|..:|.::|||..||  |....::.:|. ..||:|.:.| .|.:|.:..| ...|.|
Zfish   408 KGEYEEAMETLKKALKLEPSTKAIHAELSKLVKRQAGENESQNWQAK-PARVFGENIA-PFLTPP 470

  Fly   406 PRE 408
            |::
Zfish   471 PKK 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fkbp59	NP_001285784.1	FKBP_C	25..117	CDD:278674	3/9 (33%)
		ppisom_GldI	<124..233	CDD:132555	29/118 (25%)
		BamD	252..>390	CDD:276939	47/150 (31%)
		TPR_12	252..329	CDD:290160	24/86 (28%)
		TPR repeat	252..280	CDD:276939	7/27 (26%)
		TPR repeat	252..280	CDD:276809	7/27 (26%)
		TPR repeat	287..326	CDD:276939	13/48 (27%)
		TPR repeat	296..326	CDD:276809	8/29 (28%)
		TPR_11	299..362	CDD:290150	22/62 (35%)
		TPR repeat	329..361	CDD:276939	12/31 (39%)
		TPR_1	331..364	CDD:278916	14/32 (44%)
		TPR repeat	331..359	CDD:276809	11/27 (41%)
fkbp16	NP_001373781.1	FKBP_C	203..288	CDD:418595	24/88 (27%)
		TPR	<305..427	CDD:223533	38/123 (31%)
		TPR repeat	312..355	CDD:276809	11/44 (25%)
		TPR repeat	360..390	CDD:276809	8/29 (28%)
		TPR_19	372..438	CDD:405276	25/65 (38%)
		TPR repeat	395..423	CDD:276809	11/27 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0545
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810