DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fkbp59 and fkbp9

DIOPT Version :9

Sequence 1:	NP_001285784.1	Gene:	Fkbp59 / 47762	FlyBaseID:	FBgn0029174	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_001003520.1	Gene:	fkbp9 / 445126	ZFINID:	ZDB-GENE-040801-23	Length:	564	Species:	Danio rerio

Alignment Length:	248	Identity:	69/248 - (27%)
Similarity:	123/248 - (49%)	Gaps:	30/248 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 HYTGRLVDGTEFDSSLSRNEPFEFSLGKGNVIKAFDMGVATMKLGERCFLTCAPNYAYGAAGSPP 102
            ||.|.|:|||.||||.|||..::..:|||.||...|.|:..:.:|||..:|..|:.|||..|:..
Zfish   277 HYNGSLLDGTFFDSSYSRNHTYDTYIGKGYVIAGMDQGLLGVCVGERRRITIPPHLAYGEEGTGT 341

  Fly   103 AIPPDATLIFELEMLGWKGEDLSPNQDGSIDRTILEASDKKRTPSDGAFVKAHISGSFEGRVFED 167
            .||..|.|:|::.::.:.      |...:::.|.::..:.......|.|||.|    :...:.:.
Zfish   342 KIPGSAVLVFDVHIIDFH------NPSDTVEITSVKLENCTYNAKRGDFVKYH----YNATLMDG 396

  Fly   168 RDVEFDYGEGKAIG-------IIDGVEIALEKMNVGETSRIKIQAKYAFGAKGNEEFKIPPNATV 225
            .|:...:..||...       ::.|:|..|..|.:||..::.|....|:|.:| .:.::|.:|.:
Zfish   397 TDIGSTHMYGKTYNVVLGSGQVVIGMEQGLTGMCIGEKRKLVIPPHLAYGERG-VDGEVPGSAVL 460

  Fly   226 EYTVKLVDCGKGLEE-----WK-------LSDEERLAEAKVYKEKGTNYFKKE 266
            .:.|::||..:||.|     |.       .|:.::..:|:|.|.:.::|..::
Zfish   461 VFEVEMVDVEEGLPEGYMFVWNNNVTPDLFSEMDKNKDAQVDKTEFSDYILQQ 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fkbp59	NP_001285784.1	FKBP_C	25..117	CDD:278674	35/78 (45%)
		ppisom_GldI	<124..233	CDD:132555	23/115 (20%)
		BamD	252..>390	CDD:276939	4/15 (27%)
		TPR_12	252..329	CDD:290160	4/15 (27%)
		TPR repeat	252..280	CDD:276939	4/15 (27%)
		TPR repeat	252..280	CDD:276809	4/15 (27%)
		TPR repeat	287..326	CDD:276939
		TPR repeat	296..326	CDD:276809
		TPR_11	299..362	CDD:290150
		TPR repeat	329..361	CDD:276939
		TPR_1	331..364	CDD:278916
		TPR repeat	331..359	CDD:276809
fkbp9	NP_001003520.1	FKBP_C	40..132	CDD:278674
		FKBP_C	152..244	CDD:278674
		FKBP_C	264..356	CDD:278674	35/78 (45%)
		FKBP_C	375..467	CDD:278674	21/96 (22%)
		EF-hand_7	488..552	CDD:290234	5/26 (19%)
		EFh	490..551	CDD:298682	5/24 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0545
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810