DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fkbp59 and fkbp8

DIOPT Version :9

Sequence 1:	NP_001285784.1	Gene:	Fkbp59 / 47762	FlyBaseID:	FBgn0029174	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_957178.1	Gene:	fkbp8 / 393858	ZFINID:	ZDB-GENE-040426-1849	Length:	406	Species:	Danio rerio

Alignment Length:	395	Identity:	94/395 - (23%)
Similarity:	160/395 - (40%)	Gaps:	129/395 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 IDLSGDGGVLKEILKEGTGTET-PHSGCTVSLHYTGRLVDGTEFDSSLSRNEPFEFSLGKGNVIK 70
            :|:.|:|.:.|::|:.|.|.:: |..|..|::|....|.:||..|..    :...|:||.|:|::
Zfish    86 LDVLGNGQLRKKVLEAGAGPDSRPQKGQNVTIHLKTALTNGTVVDEL----KDLSFTLGDGDVLQ 146

  Fly    71 AFDMGVATMKLGERCFLTCAPNYAYGAAG-SPPAIPPDATLIFELEMLGWKGEDLSPNQDGSIDR 134
            |.|:.|..|::||:..:..|..|||||.| |.||:||||.|:.|:::|         :.|.::|
Zfish   147 ALDLTVQLMEMGEKALIEAAAKYAYGALGSSAPAVPPDADLLLEVQLL---------SADEALD- 201

  Fly   135 TILEASDKKRTPSDGAFVKAHISGSFEGRVFEDRDVEFDYGEGKAIGIIDGVEIALEKMNVGETS 199
                                                                   ||.|
Zfish   202 -------------------------------------------------------LELM------ 205

  Fly   200 RIKIQAKYAFGAKGNEEFKIPPNATVEYTVKLVDCGKGLEEWKLSDEERLAEAKVYKEKGTNYFK 264
                                ||:                        ||:..|...:|:|..:::
Zfish   206 --------------------PPS------------------------ERIILANRKRERGNVHYQ 226

  Fly   265 KENWALAIKMY------TKCKNILPTTVHTNEEVKKIKVATHSNIALCHQKSNDHFEAK-QECNE 322
            :.::|.|:..|      |:..:.:..:....||:..:||...:|:|....|. ||:||. :.|..
Zfish   227 RADYAFAVNSYGIALQITEASSRVDISQEEEEELLDMKVKCLNNMAAAQLKL-DHYEAALRSCVS 290

  Fly   323 VLALDKNNVKALYRRGQCNLTINELEDALEDFQKVIQLEPGNKAAANQVIICKQKLKESKNKEKK 387
            |||...:|||||:|:|:......|..:|::..:..::|||.||....::....:|..|.|..|:.
Zfish   291 VLAHQPDNVKALFRKGKVLALQGEFAEAIKTLKMALKLEPSNKTIHAELSKLVKKHSEQKGAEQA 355

  Fly   388 LYANM 392
            :|..|
Zfish   356 MYKKM 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fkbp59	NP_001285784.1	FKBP_C	25..117	CDD:278674	36/93 (39%)
		ppisom_GldI	<124..233	CDD:132555	7/108 (6%)
		BamD	252..>390	CDD:276939	40/144 (28%)
		TPR_12	252..329	CDD:290160	22/83 (27%)
		TPR repeat	252..280	CDD:276939	7/33 (21%)
		TPR repeat	252..280	CDD:276809	7/33 (21%)
		TPR repeat	287..326	CDD:276939	14/39 (36%)
		TPR repeat	296..326	CDD:276809	12/30 (40%)
		TPR_11	299..362	CDD:290150	21/63 (33%)
		TPR repeat	329..361	CDD:276939	9/31 (29%)
		TPR_1	331..364	CDD:278916	11/32 (34%)
		TPR repeat	331..359	CDD:276809	8/27 (30%)
fkbp8	NP_957178.1	FKBP_C	106..194	CDD:278674	35/91 (38%)
		TPR_11	214..296	CDD:290150	22/82 (27%)
		TPR repeat	214..259	CDD:276809	7/44 (16%)
		TPR repeat	265..293	CDD:276809	10/28 (36%)
		TPR_11	266..330	CDD:290150	21/64 (33%)
		TPR repeat	298..328	CDD:276809	9/29 (31%)
		TPR_1	299..332	CDD:278916	11/32 (34%)
		TPR repeat	333..361	CDD:276809	7/28 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0545
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810