DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fkbp59 and STIMATE

DIOPT Version :9

Sequence 1:	NP_001285784.1	Gene:	Fkbp59 / 47762	FlyBaseID:	FBgn0029174	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_940965.1	Gene:	STIMATE / 375346	HGNCID:	30526	Length:	294	Species:	Homo sapiens

Alignment Length:	66	Identity:	19/66 - (28%)
Similarity:	27/66 - (40%)	Gaps:	28/66 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   375 KQKLKE------SKNKEKKLYANMFTKLAANDKETEPP---------RETDVLSKCGEWSEEDAK 424
            |.||:|      |:|..|..|     :.||:.:|:|..         .|:||        |||.:
Human   224 KAKLEERGANQDSRNGSKVRY-----RRAASHEESESEILISADDEMEESDV--------EEDLR 275

  Fly   425 R 425
            |
Human   276 R 276

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fkbp59	NP_001285784.1	FKBP_C	25..117	CDD:278674
		ppisom_GldI	<124..233	CDD:132555
		BamD	252..>390	CDD:276939	7/20 (35%)
		TPR_12	252..329	CDD:290160
		TPR repeat	252..280	CDD:276939
		TPR repeat	252..280	CDD:276809
		TPR repeat	287..326	CDD:276939
		TPR repeat	296..326	CDD:276809
		TPR_11	299..362	CDD:290150
		TPR repeat	329..361	CDD:276939
		TPR_1	331..364	CDD:278916
		TPR repeat	331..359	CDD:276809
STIMATE	NP_940965.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		STIMATE	100..219	CDD:403562
		GXXXG motif. /evidence=ECO:0000303\|PubMed:26322679	149..153
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	227..268		10/45 (22%)
		Required for localization in the endoplasmic reticulum. /evidence=ECO:0000269\|PubMed:26322679	241..246		2/9 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D897391at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010