DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fkbp59 and fkbp5

DIOPT Version :9

Sequence 1:	NP_001285784.1	Gene:	Fkbp59 / 47762	FlyBaseID:	FBgn0029174	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	XP_005166078.1	Gene:	fkbp5 / 368924	ZFINID:	ZDB-GENE-030616-630	Length:	477	Species:	Danio rerio

Alignment Length:	429	Identity:	172/429 - (40%)
Similarity:	264/429 - (61%)	Gaps:	12/429 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 GNKIDLSGDGGVLKEILKEGTGTETPHSGCTVSLHYTGRLVDGTEFDSSLSRNEPFEFSLGKGNV 68
            |..:..:||.||.|.:.:.|...|.|..|..|.:||||||:.|.:|||||.|.|||.|::|||.|
Zfish    46 GTAVTPNGDSGVCKIVKQHGVEGERPMIGDRVFVHYTGRLLSGKKFDSSLDRKEPFVFNVGKGQV 110

  Fly    69 IKAFDMGVATMKLGERCFLTCAPNYAYGAAGSPPAIPPDATLIFELEMLGWKGEDLSPNQDGSID 133
            |||:|:.|.:|:.||.|.:.|.|.||||:|||||.:||::||:||:|:|.::||:|:  :||.|.
Zfish   111 IKAWDICVCSMQKGEVCLMLCKPEYAYGSAGSPPKVPPNSTLVFEIELLNFRGEELT--EDGGIV 173

  Fly   134 RTILEASDKKRTPSDGAFVKAHISGSFEGRVFEDRDVEFDYGEGKAIGIIDGVEIALEKMNVGET 198
            |.|....:....|::||.|..|:.|...||:|:.|||.|..||.:.:|:..||:.|:||:..||.
Zfish   174 RRIKVKGEGYSNPNEGATVHVHLEGWCGGRLFDSRDVTFAVGESEDVGVPLGVDRAMEKLQKGEC 238

  Fly   199 SRIKIQAKYAFGAKGNEEFKIPPNATVEYTVKLVDCGKGLEEWKLSDEERLAEAKVYKEKGTNYF 263
            ..:.::.|||||.:|.:|..|..||.:.|.|.|.|..|..|.|::..:|:|..|.:.|:|||.||
Zfish   239 CLLYLKPKYAFGKEGRKEHDIGSNAELLYEVTLKDFEKAKETWEMDLKEKLERAVLVKQKGTQYF 303

  Fly   264 KKENWALAIKMYTKCKNILPTTVHTNEE----VKKIKVATHSNIALCHQKSNDHFEAKQECNEVL 324
            |...:..|:..|.:..|.|.......:|    ::.:.:..|.|:|||:.:..::.:..:.||:|:
Zfish   304 KAGRYNYAVIQYQRIVNWLEMECGNGKEQLQAIQALLLVAHLNLALCYLRLREYSQTVENCNKVM 368

  Fly   325 ALDKNNVKALYRRGQCNLTINELEDALEDFQKVIQLEPGNKAAANQVIICKQKLKESKNKEKKLY 389
            .||..|.|||||||:..|..||...||.||::|:|:...|:||.:|::||:.|::|...::||:|
Zfish   369 ELDPENEKALYRRGEARLLRNEFSLALMDFKQVLQVNSFNRAARSQILICQHKIREHHERDKKIY 433

  Fly   390 ANMFTKLAANDKET---EPPRETDVLSKCGEWSEEDAKR 425
            ||||.:.|.:|.:.   :..:|..|:|   :.:::..||
Zfish   434 ANMFQRFAEHDAKVCRLKRKKEESVIS---DQNKQGLKR 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fkbp59	NP_001285784.1	FKBP_C	25..117	CDD:278674	52/91 (57%)
		ppisom_GldI	<124..233	CDD:132555	42/108 (39%)
		BamD	252..>390	CDD:276939	50/141 (35%)
		TPR_12	252..329	CDD:290160	23/80 (29%)
		TPR repeat	252..280	CDD:276939	10/27 (37%)
		TPR repeat	252..280	CDD:276809	10/27 (37%)
		TPR repeat	287..326	CDD:276939	9/42 (21%)
		TPR repeat	296..326	CDD:276809	8/29 (28%)
		TPR_11	299..362	CDD:290150	27/62 (44%)
		TPR repeat	329..361	CDD:276939	17/31 (55%)
		TPR_1	331..364	CDD:278916	16/32 (50%)
		TPR repeat	331..359	CDD:276809	15/27 (56%)
fkbp5	XP_005166078.1	FKBP_C	69..159	CDD:278674	52/89 (58%)
		FkpA	<167..271	CDD:223619	40/105 (38%)
		TPR_11	291..372	CDD:290150	22/80 (28%)
		TPR repeat	292..320	CDD:276809	10/27 (37%)
		TPR repeat	340..370	CDD:276809	8/29 (28%)
		TPR_11	343..405	CDD:290150	27/61 (44%)
		TPR	343..374	CDD:197478	10/30 (33%)
		TPR repeat	375..403	CDD:276809	15/27 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	123	1.000	Domainoid score	I5548
eggNOG	1	0.900	-	-		E1_COG0545
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	378	1.000	Inparanoid score	I2038
OMA	1	1.010	-	-		QHG54040
OrthoDB	1	1.010	-	-		D531594at33208
OrthoFinder	1	1.000	-	-		FOG0002252
OrthoInspector	1	1.000	-	-		otm24301
orthoMCL	1	0.900	-	-		OOG6_100299
Panther	1	1.100	-	-	O	PTHR10516
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1919
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.880