DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fkbp59 and FKBP15

DIOPT Version :9

Sequence 1:	NP_001285784.1	Gene:	Fkbp59 / 47762	FlyBaseID:	FBgn0029174	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_056073.1	Gene:	FKBP15 / 23307	HGNCID:	23397	Length:	1219	Species:	Homo sapiens

Alignment Length:	556	Identity:	113/556 - (20%)
Similarity:	193/556 - (34%)	Gaps:	167/556 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 ILKEGTGTETPHSGCTVSLHYTGRL----VDGTEFDSSLSRNEPFEFSLGKGNVIKAFDMGVATM 79
            |:.:|...|.   |.::.:.|||.|    |.|..|||:.::::.....||.|.|||.::.|:..|
Human   187 IVADGPAVEV---GDSLEVAYTGWLFQNHVLGQVFDSTANKDKLLRLKLGSGKVIKGWEDGMLGM 248

  Fly    80 KLGERCFLTCAPNYAYGAAGSPPAI----PPDATLIFELEM--------LGWKGEDLSPNQDGSI 132
            |.|.:..|...|..|.|:.|   .|    ..|:.|:||:|:        .|..|..:| ::|.:.
Human   249 KKGGKRLLIVPPACAVGSEG---VIGWTQATDSILVFEVEVRRVKFARDSGSDGHSVS-SRDSAA 309

  Fly   133 DRTI-----LEASDKKRTPSDGAF--------------------------VKAHISG-------- 158
            ...|     |.|......|:...|                          |||.:..
Human   310 PSPIPGADNLSADPVVSPPTSIPFKSGEPALRTKSNSLSEQLAINTSPDAVKAKLISRMAKMGQP 374

  Fly   159 -------SFEGRVFEDRDVEFDYGEGKAIGIIDGVEIALEKMN---------VGETSRIKIQAKY 207
                   ..:....|..||....|.|:.: :...|:.:|...:         ..:.|...:||..
Human   375 MLPILPPQLDSNDSEIEDVNTLQGGGQPV-VTPSVQPSLHPAHPALPQMTSQAPQPSVTGLQAPS 438

  Fly   208 A-----------FGAKGN----------EEFKIPPNATVEYTVKLVD-------------CGKG- 237
            |           ....||          :.:..|..:.|...::.|.             .|.|
Human   439 AALMQVSSLDSHSAVSGNAQSFQPYAGMQAYAYPQASAVTSQLQPVRPLYPAPLSQPPHFQGSGD 503

  Fly   238 ------LEEWKLSDEERLAEAKVYKEKGTNYFKKENWALAIKMYTKCKNIL----PTTVHTNEEV 292
                  .|..:.:.|.|:|.:||..:......|.|.    ::.::...::|    ..|:.|:..:
Human   504 MASFLMTEARQHNTEIRMAVSKVADKMDHLMTKVEE----LQKHSAGNSMLIPSMSVTMETSMIM 564

  Fly   293 KKIKVATHSNIALCH---QKSNDHFEAKQECNEVLALDKNNVKALYRRGQCNLTI----NELEDA 350
            ..|:.....|..|..   :|||...|...:.:|::..::..|:      |.||.:    |.|:.|
Human   565 SNIQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVE------QSNLMMEKRNNSLQTA 623

  Fly   351 LEDFQ-KVIQLEPGN-------KAAANQVIICKQKLKESKNKEKKLYANMFTKLAANDKETEPPR 407
            .|:.| :|:..|...       .||..||...:.|:...:.||.:|...:          ||..:
Human   624 TENTQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQL----------TESLK 678

  Fly   408 ETDVL--------SKCGEWSEEDAKREAELTLERDN 435
            |||:|        :|..|..|...:.:::...|:.|
Human   679 ETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQN 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fkbp59	NP_001285784.1	FKBP_C	25..117	CDD:278674	32/107 (30%)
		ppisom_GldI	<124..233	CDD:132555	25/184 (14%)
		BamD	252..>390	CDD:276939	34/156 (22%)
		TPR_12	252..329	CDD:290160	15/83 (18%)
		TPR repeat	252..280	CDD:276939	4/27 (15%)
		TPR repeat	252..280	CDD:276809	4/27 (15%)
		TPR repeat	287..326	CDD:276939	9/41 (22%)
		TPR repeat	296..326	CDD:276809	7/32 (22%)
		TPR_11	299..362	CDD:290150	17/70 (24%)
		TPR repeat	329..361	CDD:276939	10/36 (28%)
		TPR_1	331..364	CDD:278916	11/37 (30%)
		TPR repeat	331..359	CDD:276809	10/32 (31%)
FKBP15	NP_056073.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	41..66
		PH-like	70..168	CDD:302622
		Important for function in growth cone organization. /evidence=ECO:0000250	72..169
		FKBP_C	193..286	CDD:278674	31/98 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	294..349		9/55 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	381..433		8/52 (15%)
		COG1340	511..781	CDD:224259	49/224 (22%)
		TIMELESS_C	589..>777	CDD:252956	32/142 (23%)
		SPEC	686..908	CDD:295325	5/29 (17%)
		DUF4515	694..871	CDD:291649	4/21 (19%)
		Ax_dynein_light	<715..780	CDD:287215	113/556 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	739..761
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..1219
		Extradiol_Dioxygenase_3B_like	<1014..>1072	CDD:294399
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0545
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810