DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fkbp59 and Fkbp14

DIOPT Version :9

Sequence 1:	NP_001285784.1	Gene:	Fkbp59 / 47762	FlyBaseID:	FBgn0029174	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_705801.1	Gene:	Fkbp14 / 231997	MGIID:	2387639	Length:	211	Species:	Mus musculus

Alignment Length:	153	Identity:	44/153 - (28%)
Similarity:	73/153 - (47%)	Gaps:	12/153 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 GCTVSLHYTGRL-VDGTEFDSSLSRN--EPFEFSLGKGNVIKAFDMGVATMKLGERCFLTCAPNY 93
            |..:.:||.|.| .||:.|.|:...|  :|..|:||...|:|.:|.|:..|.:||:..||..|..
Mouse    45 GDLMLVHYEGYLEKDGSLFHSTHKHNNGQPVWFTLGILEVLKGWDQGLKGMCVGEKRKLTVPPAL 109

  Fly    94 AYGAAGSPPAIPPDATLIFELEMLGWKG--------EDLSPNQDGSIDRTILEASDKKRTPSDGA 150
            .||..|. ..|||::||||.:::|..:.        :::..|.|..:.:..::...:|.....||
Mouse   110 GYGKEGK-GKIPPESTLIFNIDLLEIRNGPRSHESFQEMDLNDDWRLSKHEVKVYLQKEFEKHGA 173

  Fly   151 FVKAHISGSFEGRVFEDRDVEFD 173
            .|......:....:|:..|.:.|
Mouse   174 VVNESHHDALVEDIFDKEDEDKD 196

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fkbp59	NP_001285784.1	FKBP_C	25..117	CDD:278674	34/87 (39%)
		ppisom_GldI	<124..233	CDD:132555	9/50 (18%)
		BamD	252..>390	CDD:276939
		TPR_12	252..329	CDD:290160
		TPR repeat	252..280	CDD:276939
		TPR repeat	252..280	CDD:276809
		TPR repeat	287..326	CDD:276939
		TPR repeat	296..326	CDD:276809
		TPR_11	299..362	CDD:290150
		TPR repeat	329..361	CDD:276939
		TPR_1	331..364	CDD:278916
		TPR repeat	331..359	CDD:276809
Fkbp14	NP_705801.1	FKBP_C	38..132	CDD:278674	34/87 (39%)
		EF-hand_7	141..204	CDD:290234	9/56 (16%)
		EFh	142..204	CDD:298682	9/55 (16%)
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	208..211
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0545
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810