DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fkbp59 and fkb-7

DIOPT Version :9

Sequence 1:	NP_001285784.1	Gene:	Fkbp59 / 47762	FlyBaseID:	FBgn0029174	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_492792.1	Gene:	fkb-7 / 172963	WormBaseID:	WBGene00001432	Length:	318	Species:	Caenorhabditis elegans

Alignment Length:	260	Identity:	52/260 - (20%)
Similarity:	77/260 - (29%)	Gaps:	96/260 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 VSLHYTGRLVDGTEFDSSLSRNEPFEFSLGKGNVIKAFDMGVATMKLGERCFLTCAPN------- 92
            |:.||.....|..:...:.... |....||.|.::...|.|:..|         ||..
Worm    96 VTFHYKVFTEDNKKVYQTYGTG-PVTIQLGTGMIMPGLDKGLKGM---------CAEELRKVRVP 150

  Fly    93 YAYGAAGSPPA---IPPDAT-LIFELEMLGWKGEDLSPNQDGSIDRTILEASDKKRTPSDGAFVK 153
            |..........   ||.|.. |||.:||:     ::.|                 .||
Worm   151 YRMSRKSKSKVWKNIPNDENWLIFNIEMV-----EIKP-----------------YTP------- 186

  Fly   154 AHISGSFEGRVFEDRDVEFDYGEGKAIGIIDGVEIALEKMNVGETSRIKIQAKYAFGAKGNEEF- 217
                                             ||..:.:::.|..::..:....|..|..:||
Worm   187 ---------------------------------EIQFKFLDLNEDEQLTNKEVQDFQKKMKKEFG 218

  Fly   218 KIPPNATVE------YTVKLVDC-GKGL---EEW-KLSD-EERLAEAKVYKEKGTNYFKKENWAL 270
            |...|..::      |.:|..|. |.|:   .|| |:.| :|:|...|..||||........|.|
Worm   219 KTWKNEDIDNVTAAGYYIKYFDVNGDGIVTEVEWLKIMDRDEKLINDKKTKEKGRKRDPGIGWIL 283

Fly 271 270
Worm 284 283

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fkbp59	NP_001285784.1	FKBP_C	25..117	CDD:278674	21/92 (23%)
		ppisom_GldI	<124..233	CDD:132555	14/115 (12%)
		BamD	252..>390	CDD:276939	7/19 (37%)
		TPR_12	252..329	CDD:290160	7/19 (37%)
		TPR repeat	252..280	CDD:276939	7/19 (37%)
		TPR repeat	252..280	CDD:276809	7/19 (37%)
		TPR repeat	287..326	CDD:276939
		TPR repeat	296..326	CDD:276809
		TPR_11	299..362	CDD:290150
		TPR repeat	329..361	CDD:276939
		TPR_1	331..364	CDD:278916
		TPR repeat	331..359	CDD:276809
fkb-7	NP_492792.1	FKBP_C	86..179	CDD:278674	21/92 (23%)
fkb-7	NP_492792.1	EFh	190..256	CDD:298682	15/65 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0545
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810