DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fkbp59 and Fkbp8

DIOPT Version :9

Sequence 1:	NP_001285784.1	Gene:	Fkbp59 / 47762	FlyBaseID:	FBgn0029174	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_001104536.1	Gene:	Fkbp8 / 14232	MGIID:	1341070	Length:	403	Species:	Mus musculus

Alignment Length:	405	Identity:	108/405 - (26%)
Similarity:	179/405 - (44%)	Gaps:	87/405 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 VDGTEFDSSLSRNEPFEFSLGKGNVIKAFDMGVATMKLGE------RCFLTCAPNYAYGAAGSP- 101
            ||..|.:..||...|.|            |||..|::..|      |.||         ||..|
Mouse    30 VDDAEEEDDLSGLPPLE------------DMGQPTVEEAEQPGALAREFL---------AATEPE 73

  Fly   102 --PAIPPDATLIFELEMLG---WKGEDLSPNQDGSIDRTILEASDKKRTPSDGAFVKAHISGSFE 161
              ||..|:..    |::||   .:.:.|.|...||            ..|..|..|..|:..|.|
Mouse    74 PAPAPAPEEW----LDILGNGLLRMKTLVPGPKGS------------SRPLKGQVVTVHLQMSLE 122

  Fly   162 G--RVFEDRDVEFDYGEGKAIGIIDGVEIALEKMNVGETSRIKIQAKYAFGAKGNEEFKIPPNAT 224
            .  ||.|:.::.|..|:   ..:|..:::::..|:||||:.:...:||.:|.:|:....|||:|.
Mouse   123 NGTRVQEEPELAFTLGD---CDVIQALDLSVPLMDVGETAMVTADSKYCYGPQGSRSPYIPPHAA 184

  Fly   225 --VEYTVKLVDCGKGLEEWKLSDEERLAEAKVYKEKGTNYFKKENWALAIKMY----------TK 277
              :|.|:|..:.|..||  .||.:||:|.|...:|.|..::::.::.||...|          ||
Mouse   185 LCLEVTLKTAEDGPDLE--MLSGQERVALANRKRECGNAHYQRADFVLAANSYDLAIKAITSNTK 247

  Fly   278 CKNILPTTVHTNEEVKKIKVATHSNIALCHQKSNDHFEAKQECNEVLALDKNNVKALYRRGQCNL 342
                :..|....||:.::||...:|:|....|.:.:..|.:.|::||....:|:|||:|:|:...
Mouse   248 ----VDMTCEEEEELLQLKVKCLNNLAASQLKLDHYRAALRSCSQVLEHQPDNIKALFRKGKVLA 308

  Fly   343 TINELEDALEDFQKVIQLEPGNKAAANQVIICKQKLKESKNKEKKLYANMFTKLAANDKETEPPR 407
            ...|..:|:...:..::|||.||....::    .||.:.:..::.....::.|:..|     |.|
Mouse   309 QQGEYSEAIPILRAALKLEPSNKTIHAEL----SKLVKKRAAQRSTETALYRKMLGN-----PSR 364

  Fly   408 ETDVLSKC---GEWS 419
               :.:||   |.||
Mouse   365 ---LPAKCPGKGAWS 376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fkbp59	NP_001285784.1	FKBP_C	25..117	CDD:278674	22/81 (27%)
		ppisom_GldI	<124..233	CDD:132555	32/112 (29%)
		BamD	252..>390	CDD:276939	35/147 (24%)
		TPR_12	252..329	CDD:290160	20/86 (23%)
		TPR repeat	252..280	CDD:276939	8/37 (22%)
		TPR repeat	252..280	CDD:276809	8/37 (22%)
		TPR repeat	287..326	CDD:276939	11/38 (29%)
		TPR repeat	296..326	CDD:276809	9/29 (31%)
		TPR_11	299..362	CDD:290150	16/62 (26%)
		TPR repeat	329..361	CDD:276939	8/31 (26%)
		TPR_1	331..364	CDD:278916	10/32 (31%)
		TPR repeat	331..359	CDD:276809	7/27 (26%)
Fkbp8	NP_001104536.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..54		11/35 (31%)
		FKBP_C	103..192	CDD:365980	29/103 (28%)
		TPR	<206..329	CDD:223533	33/126 (26%)
		TPR 1	212..245		6/32 (19%)
		TPR repeat	245..292	CDD:276809	14/50 (28%)
		TPR 2	263..296		8/32 (25%)
		TPR 3	297..330		10/32 (31%)
		TPR repeat	297..325	CDD:276809	7/27 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0545
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810