DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fkbp59 and Fkbp10

DIOPT Version :9

Sequence 1:	NP_001285784.1	Gene:	Fkbp59 / 47762	FlyBaseID:	FBgn0029174	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_034351.2	Gene:	Fkbp10 / 14230	MGIID:	104769	Length:	581	Species:	Mus musculus

Alignment Length:	257	Identity:	73/257 - (28%)
Similarity:	114/257 - (44%)	Gaps:	42/257 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 ETPHSGCT--------VSLHYTGRLVDGTEFDSSLSRNEPFEFSLGKGNVIKAFDMGVATMKLGE 83
            |.| .||.        :..||.|.|:|||.||||.|||..:...:|:|.:|...|.|:....:||
Mouse   273 ELP-QGCVRRAVAGDFMRYHYNGSLMDGTLFDSSYSRNHTYNTYVGQGYIIPGMDQGLQGACIGE 336

  Fly    84 RCFLTCAPNYAYGAAGSPPAIPPDATLIFELEMLGWKGEDLSPNQDGSIDRTILEASDKKRTPSD 148
            |..:|..|:.|||..|:...||..|.|||::.::.:.    :|:....|........:...|...
Mouse   337 RRRITVPPHLAYGENGTGDKIPGSAVLIFDVHVIDFH----NPSDPVEIKTLSRPPENCNETSKI 397

  Fly   149 GAFVKAHISGS-FEG-RVFEDRDV----EFDYGEGKAIGIIDGVEIALEKMNVGETSRIKIQAKY 207
            |.|::.|.:.| .:| |:|...|.    |...|..|   :|:|::..|:.|.|||..::.:....
Mouse   398 GDFIRYHYNCSLLDGTRLFSSHDYEAPQEITLGANK---VIEGLDRGLQGMCVGERRQLIVPPHL 459

  Fly   208 AFGAKGNEEFKIPPNATVEYTVKLVDCGKGLEE-----WKLSDEERLAEAKVYKEKGTNYFK 264
            |.|..|..  .:|.:|.:.:.|:||....||..     |             |::..|:.|:
Mouse   460 AHGENGAR--GVPGSAVLLFEVELVSREDGLPTGYLFVW-------------YQDPSTSLFE 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fkbp59	NP_001285784.1	FKBP_C	25..117	CDD:278674	38/97 (39%)
		ppisom_GldI	<124..233	CDD:132555	28/114 (25%)
		BamD	252..>390	CDD:276939	3/13 (23%)
		TPR_12	252..329	CDD:290160	3/13 (23%)
		TPR repeat	252..280	CDD:276939	3/13 (23%)
		TPR repeat	252..280	CDD:276809	3/13 (23%)
		TPR repeat	287..326	CDD:276939
		TPR repeat	296..326	CDD:276809
		TPR_11	299..362	CDD:290150
		TPR repeat	329..361	CDD:276939
		TPR_1	331..364	CDD:278916
		TPR repeat	331..359	CDD:276809
Fkbp10	NP_034351.2	FKBP_C	54..146	CDD:278674
		FKBP_C	166..258	CDD:278674
		FKBP_C	278..370	CDD:278674	35/91 (38%)
		FKBP_C	391..482	CDD:278674	25/95 (26%)
		EF-hand_7	504..567	CDD:290234	1/3 (33%)
		EFh	505..566	CDD:238008	1/2 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	533..581
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	578..581
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0545
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810