DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fkbp59 and Aipl1

DIOPT Version :9

Sequence 1:	NP_001285784.1	Gene:	Fkbp59 / 47762	FlyBaseID:	FBgn0029174	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	XP_006532060.1	Gene:	Aipl1 / 114230	MGIID:	2148800	Length:	333	Species:	Mus musculus

Alignment Length:	397	Identity:	79/397 - (19%)
Similarity:	149/397 - (37%)	Gaps:	99/397 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 GVLKEILKEGTGTETPH--SGCTVSLHYTGRLVDG--TEFDSSLSRNEPFEFSLGKGNVIKAFDM 74
            ||.|.||..||| |.|.  :|..|:.|:.....|.  |..|.|....:|....:|....::.::.
Mouse    16 GVKKTILHGGTG-ELPSFITGSRVTFHFRTMKCDDERTVIDDSKQVGQPMSIIIGNMFKLEVWET 79

  Fly    75 GVATMKLGERCFLTCAPNYAYGAAGSPPAIPPDATLIFELEMLGWKGEDLSPNQDGSIDRTILEA 139
            .:.:|:|||.....|...:               |.::.:                 :.|::.:.
Mouse    80 LLTSMRLGEVAEFWCDTIH---------------TGVYPM-----------------LSRSLRQV 112

  Fly   140 SDKKRTPSDGAFVKAHISG-----SFEGRVFEDRDVEFDYGEGKAIGIIDGVEIALEKMNVGETS 199
            ::.|    |......|..|     ::....:||.| |........:.:|:
Mouse   113 AEGK----DPTSWHVHTCGLANMFAYHTLGYEDLD-ELQKEPQPLVFLIE--------------- 157

  Fly   200 RIKIQAKYAFGAKGNEEFKIPPNATVEYTVKLVDCGKGLEEWKLSDEERLAEAKVYKEKGTNYFK 264
            .::::|               ||   ||.         .|.|.|::|||:....:...:|...:|
Mouse   158 LLQVEA---------------PN---EYQ---------RETWNLNNEERMQAVPLLHGEGNRLYK 195

  Fly   265 KENWALAIKMYTKCKNILPTTVHTNE---EVKKIKVATHSNIAL-----CHQKSNDHFEAKQECN 321
            ...:..|...|.:....| ..:.|.|   ||:.:|:....|..:     |..|..:::|..:..:
Mouse   196 LGRYDQAATKYQEAIVCL-RNLQTKEKPWEVEWLKLEKMINTLILNYCQCLLKKEEYYEVLEHTS 259

  Fly   322 EVLALDKNNVKALYRRGQCNLTINELEDALEDFQKVIQLEPG-NKAAANQVIICKQKLKESKNKE 385
            ::|......|||.|.|.:.:..:...|:|..|.:||::|||. .||...::.:.:.:|.:.:.:|
Mouse   260 DILRHHPGIVKAYYMRARAHAEVWNAEEAKADLEKVLELEPSMRKAVLRELRLLESRLADKQEEE 324

  Fly   386 KKLYANM 392
            ::...:|
Mouse   325 RQRCRSM 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fkbp59	NP_001285784.1	FKBP_C	25..117	CDD:278674	18/95 (19%)
		ppisom_GldI	<124..233	CDD:132555	15/113 (13%)
		BamD	252..>390	CDD:276939	32/146 (22%)
		TPR_12	252..329	CDD:290160	15/84 (18%)
		TPR repeat	252..280	CDD:276939	4/27 (15%)
		TPR repeat	252..280	CDD:276809	4/27 (15%)
		TPR repeat	287..326	CDD:276939	10/46 (22%)
		TPR repeat	296..326	CDD:276809	6/34 (18%)
		TPR_11	299..362	CDD:290150	16/67 (24%)
		TPR repeat	329..361	CDD:276939	10/31 (32%)
		TPR_1	331..364	CDD:278916	13/33 (39%)
		TPR repeat	331..359	CDD:276809	10/27 (37%)
Aipl1	XP_006532060.1	FKBP_C	35..>94	CDD:388582	13/58 (22%)
		TPR	<184..326	CDD:223533	32/142 (23%)
		TPR repeat	185..229	CDD:276809	9/44 (20%)
		TPR repeat	234..264	CDD:276809	5/29 (17%)
		PLN03088	266..>309	CDD:215568	15/42 (36%)
		TPR repeat	269..297	CDD:276809	10/27 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D897391at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920