DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fkbp59 and fkbp4

DIOPT Version :9

Sequence 1:	NP_001285784.1	Gene:	Fkbp59 / 47762	FlyBaseID:	FBgn0029174	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	XP_012810222.1	Gene:	fkbp4 / 100379681	XenbaseID:	XB-GENE-948088	Length:	450	Species:	Xenopus tropicalis

Alignment Length:	431	Identity:	191/431 - (44%)
Similarity:	271/431 - (62%)	Gaps:	15/431 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 EGNKIDLSGDGGVLKEILKEGTGTETPHSGCTVSLHYTGRLVDGTEFDSSLSRNEPFEFSLGKGN 67
            ||..|...||.||||.|.|||||..||..|..||:||||.|.|||:||||..|.:.|.|.||||.
Frog    17 EGTDITPKGDQGVLKLIKKEGTGENTPMIGDKVSVHYTGWLTDGTQFDSSRDRKDKFTFDLGKGE 81

  Fly    68 VIKAFDMGVATMKLGERCFLTCAPNYAYGAAGSPPAIPPDATLIFELEMLGWKGEDLSPNQDGSI 132
            ||||:|:.|||||:||.|.:.|.|.||||.:||||.|||:|.|:||:|:..::||||:.::||.|
Frog    82 VIKAWDIAVATMKVGEICQIVCKPEYAYGTSGSPPKIPPNAVLVFEVELFDFQGEDLTQDEDGGI 146

  Fly   133 DRTILEASDKKRTPSDGAFVKAHISGSFEGRVFEDRDVEFDYGEGKAIGIIDGVEIALEKMNVGE 197
            .|.|....:....|::||.|:.|:.|:.|||||::|:::|:.|||::|||..|||.|:::|..||
Frog   147 IRRIQVKGEGYSKPNEGAVVEIHVKGTHEGRVFDERELKFEVGEGESIGIPPGVETAIQQMEKGE 211

  Fly   198 TSRIKIQAKYAFGAKGNEEFKIPPNATVEYTVKLVDCGKGLEEWKLSDEERLAEAKVYKEKGTNY 262
            .:.:.::.||.||..|:|:::|||.|.::|.::|....|..|.|:::.||:|.:..:.||:||.|
Frog   212 KAILYLKPKYGFGTTGSEKYQIPPGAELQYDIRLKSFEKAKESWEMNAEEKLEQGCLVKERGTQY 276

  Fly   263 FKKENWALAIKMYTKCKNILPTTVH----TNEEVKKIK---VATHSNIALCHQKSNDHFEAKQEC 320
            ||...:..|...|   |.|:....|    :.||..|.|   :|...|:|.|:.|..:|..|...|
Frog   277 FKDGRYRQATIQY---KKIIQWLEHESGLSKEEDAKAKSLILAASLNLAACYLKLGEHRAALDHC 338

  Fly   321 NEVLALDKNNVKALYRRGQCNLTINELEDALEDFQKVIQLEPGNKAAANQVIICKQKLKESKNKE 385
            |:.|.||.:|.|.|:|||:..:..|:||.|..||.||:||.|.||||..|:..|:.::::...:|
Frog   339 NKALELDPSNEKGLFRRGEAYMCTNDLEQARNDFTKVLQLYPANKAARAQLGQCQVRIRQQTERE 403

  Fly   386 KKLYANMFTKLAANDKETEPPRETDVLSKCGEWSEEDAKRE 426
            ||:|||||.:||..:.:..||..:|:     |..|.|...|
Frog   404 KKIYANMFQRLAEKESKEVPPAPSDI-----EMKEPDENGE 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fkbp59	NP_001285784.1	FKBP_C	25..117	CDD:278674	56/91 (62%)
		ppisom_GldI	<124..233	CDD:132555	44/108 (41%)
		BamD	252..>390	CDD:276939	54/144 (38%)
		TPR_12	252..329	CDD:290160	28/83 (34%)
		TPR repeat	252..280	CDD:276939	9/27 (33%)
		TPR repeat	252..280	CDD:276809	9/27 (33%)
		TPR repeat	287..326	CDD:276939	15/45 (33%)
		TPR repeat	296..326	CDD:276809	11/32 (34%)
		TPR_11	299..362	CDD:290150	27/62 (44%)
		TPR repeat	329..361	CDD:276939	15/31 (48%)
		TPR_1	331..364	CDD:278916	16/32 (50%)
		TPR repeat	331..359	CDD:276809	13/27 (48%)
fkbp4	XP_012810222.1	FKBP_C	39..130	CDD:365980	55/90 (61%)
		FKBP_C	156..246	CDD:365980	37/89 (42%)
		TPR	<237..380	CDD:223533	53/145 (37%)
		TPR repeat	270..294	CDD:276809	11/26 (42%)
		TPR repeat	307..344	CDD:276809	12/36 (33%)
		TPR repeat	349..377	CDD:276809	13/27 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	119	1.000	Domainoid score	I5744
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	369	1.000	Inparanoid score	I2097
OMA	1	1.010	-	-		QHG54040
OrthoDB	1	1.010	-	-		D531594at33208
OrthoFinder	1	1.000	-	-		FOG0002252
OrthoInspector	1	1.000	-	-		oto105167
Panther	1	1.100	-	-	LDO	PTHR10516
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1919
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.080