DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fkbp59 and aipl1

DIOPT Version :9

Sequence 1:	NP_001285784.1	Gene:	Fkbp59 / 47762	FlyBaseID:	FBgn0029174	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	XP_012813043.1	Gene:	aipl1 / 100101778	XenbaseID:	XB-GENE-921760	Length:	333	Species:	Xenopus tropicalis

Alignment Length:	406	Identity:	87/406 - (21%)
Similarity:	154/406 - (37%)	Gaps:	101/406 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 GVLKEILKEGTGTETPH--SGCTVSLHYTGRLVDG--TEFDSSLSRNEPFEFSLGKGNVIKAFDM 74
            ||.|:|...|.| :.|.  :|..|:.|:.....|.  |..|.|.....|.|..:|....::.::|
Frog    11 GVKKKIYHGGNG-DLPKFITGAKVTFHFRTLKCDDERTVIDDSKKVGVPMEIIIGNMFKLEVWEM 74

  Fly    75 GVATMKLGERCFLTCAPNYAYGAAGSPPAIPPDATLIFELEMLGWKGEDLSPNQDGSIDRTILEA 139
            .:::|::||.....|                 |.|           ...|.|....|: |.|.|.
Frog    75 LLSSMRIGEVAEFWC-----------------DVT-----------HTGLYPLVSKSL-RRIAEG 110

  Fly   140 SDKKRTPSDGAFVKAHISGSFEGRVFEDRDVEFDYGEGKAIGIIDGVEIALEKMNVGETSRIKIQ 204
            .|    |:|.......::..|........|::....|.|.:..:      ||.:.|...|..|
Frog   111 KD----PTDWHMHTCGLANMFAYHTLGYEDLDELQKEPKPLIFV------LELLKVESPSAYK-- 163

  Fly   205 AKYAFGAKGNEEFKIPPNATVEYTVKLVDCGKGLEEWKLSDEERLAEAKVYKEKGTNYFKKENWA 269
                                             .|.|.|:::|:|....:...:|...||...:.
Frog   164 ---------------------------------RETWALNNDEKLKAVPILHGEGNRLFKLGRYE 195

  Fly   270 LAIKMYTK---C-KNILPTTVHTNE---EVKKIKVATHSNIAL-----CHQKSNDHFEAKQECNE 322
            .||..|.:   | ||:     .|.|   ||..:|:....|..:     |..:..:::|..::..:
Frog   196 DAINKYKEGVICLKNL-----QTKEKPWEVPWMKLEKMINTLVLNYCQCLLRMEEYYEVIEQTTD 255

  Fly   323 VLALDKNNVKALYRRGQCNLTI-NELEDALEDFQKVIQLEPG-NKAAANQVIICKQKLKESKNKE 385
            ::.......||.:.||:.|..: ||.| :.:||.||::::|. :|....::.|.:.:::|.:.:|
Frog   256 LIQHHPGLTKAYFIRGKANAEVWNEAE-SKKDFDKVLEMDPAMSKVVKKEIRILECRMQEKEEEE 319

  Fly   386 KKLYANMFTKLAANDK 401
            |..|.|:|::  .|:|
Frog   320 KLRYKNLFSE--TNEK 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fkbp59	NP_001285784.1	FKBP_C	25..117	CDD:278674	19/95 (20%)
		ppisom_GldI	<124..233	CDD:132555	18/108 (17%)
		BamD	252..>390	CDD:276939	35/151 (23%)
		TPR_12	252..329	CDD:290160	17/88 (19%)
		TPR repeat	252..280	CDD:276939	7/31 (23%)
		TPR repeat	252..280	CDD:276809	7/31 (23%)
		TPR repeat	287..326	CDD:276939	8/46 (17%)
		TPR repeat	296..326	CDD:276809	4/34 (12%)
		TPR_11	299..362	CDD:290150	15/68 (22%)
		TPR repeat	329..361	CDD:276939	12/32 (38%)
		TPR_1	331..364	CDD:278916	13/34 (38%)
		TPR repeat	331..359	CDD:276809	12/28 (43%)
aipl1	XP_012813043.1	FKBP_C	30..>89	CDD:388582	14/58 (24%)
		TPR repeat	180..209	CDD:276809	7/28 (25%)
		TPR repeat	214..259	CDD:276809	7/44 (16%)
		TPR repeat	264..292	CDD:276809	12/28 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D897391at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010