DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment betaggt-II and FNTB

DIOPT Version :9

Sequence 1:	NP_524894.1	Gene:	betaggt-II / 47757	FlyBaseID:	FBgn0028970	Length:	347	Species:	Drosophila melanogaster
Sequence 2:	NP_002019.1	Gene:	FNTB / 2342	HGNCID:	3785	Length:	437	Species:	Homo sapiens

Alignment Length:	315	Identity:	102/315 - (32%)
Similarity:	159/315 - (50%)	Gaps:	26/315 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LQFWKHVEYIENHGKQEDDYEYCMTEFLRMSGIYWGTTALDIMGQ-LERLERKSIIEFVKRCQCP 92
            ||..||..|::...:|..|...|: :..|....||...:|:::.: :.::....:.:|::.||.|
Human    73 LQREKHFHYLKRGLRQLTDAYECL-DASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSP 136

  Fly    93 NTGGFAPCEGHDPHLLYTLSAIQILC---TYDALEEIDREAVVRFVVGLQQPDGSFFGDKWGEVD 154
            . |||....|..|||..|.:|:..||   |.:|.:.|:||.:::::..|:||||||.....||||
Human   137 E-GGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYDIINREKLLQYLYSLKQPDGSFLMHVGGEVD 200

  Fly   155 TRFSFCA--VASLTLLGRMEQTIDVEKAVKFVLSCCNQTDGGFGSKPGAESHAGLIYCCVGFFSL 217
            .|.::||  |||||.:    .|.|:.:.....::.|...:||.|..||.|:|.|..:|.:....:
Human   201 VRSAYCAASVASLTNI----ITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVI 261

  Fly   218 THRLHLLDVDKLGWWLCERQLP-SGGLNGRPEKLPDVCYSWWVLASLTIMGRL------------ 269
            ..|...|::..|..|:..||:. .||..||..||.|.|||:|....|.::.|.
Human   262 LKRERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMS 326

  Fly   270 HWI-SSEKLQQFILSCQDTETGGFSDRTGNMPDIFHTLFGIGGLSLLGHSGLKAI 323
            ||: ..:.||::||.|.....||..|:.|...|.:||.:.:.|||:..|.|..|:
Human   327 HWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAM 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
betaggt-II	NP_524894.1	GGTase-II	29..315	CDD:239224	99/305 (32%)
betaggt-II	NP_524894.1	PLN03201	33..340	CDD:215630	100/311 (32%)
FNTB	NP_002019.1	FTase	75..373	CDD:239223	97/303 (32%)
		PFTB 1	123..164		15/41 (37%)
		PFTB 2	174..215		20/40 (50%)
		PFTB 3	222..263		10/40 (25%)
		Farnesyl diphosphate binding. /evidence=ECO:0000269\|PubMed:11687658, ECO:0000269\|PubMed:12036349, ECO:0000269\|PubMed:12825937, ECO:0000269\|PubMed:15451670, ECO:0000269\|PubMed:16893176	248..251		1/2 (50%)
		PFTB 4	270..312		16/41 (39%)
		Farnesyl diphosphate binding. /evidence=ECO:0000269\|PubMed:11687658, ECO:0000269\|PubMed:12036349, ECO:0000269\|PubMed:12825937, ECO:0000269\|PubMed:15451670, ECO:0000269\|PubMed:16893176	291..294		1/2 (50%)
		Farnesyl diphosphate binding. /evidence=ECO:0000269\|PubMed:11687658, ECO:0000269\|PubMed:12036349, ECO:0000269\|PubMed:12825937, ECO:0000269\|PubMed:15451670, ECO:0000269\|PubMed:16893176	300..303		2/2 (100%)
		PFTB 5	332..374		15/41 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5029
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1042804at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820