DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment betaggt-II and Pggt1b

DIOPT Version :9

Sequence 1:	NP_524894.1	Gene:	betaggt-II / 47757	FlyBaseID:	FBgn0028970	Length:	347	Species:	Drosophila melanogaster
Sequence 2:	NP_766215.1	Gene:	Pggt1b / 225467	MGIID:	1917514	Length:	377	Species:	Mus musculus

Alignment Length:	349	Identity:	101/349 - (28%)
Similarity:	160/349 - (45%)	Gaps:	42/349 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 GGGQKLQFW--KHVEYIENHGKQEDDYEYCMTEFLRMSGIYWGTTALDIMGQLERLERKSIIEFV 86
            |.|::|.|.  :||.:.: ...|.....|...|..|::..::..:.||::..|:.:.:..|||::
Mouse    13 GEGERLDFLRDRHVRFFQ-RCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWI 76

  Fly    87 --------------KRC-------------QCPNTGGFAPCEGHDPHLLYT-LSAIQILCTYDAL 123
                          .||             ...|.|...|.:.....:.|| ||.:.||  .|.|
Mouse    77 YSLQVLPTEDRSNLSRCGFRGSSYLGIPFNPSKNPGAAHPYDSGHIAMTYTGLSCLIIL--GDDL 139

  Fly   124 EEIDREAVVRFVVGLQQPDGSFFGDKWG-EVDTRFSFCAVASLTLLGRMEQTIDVEKAVKFVLSC 187
            ..:|:||.:..:..||..||||.....| |.|.||.:||.....:|... ..:|::||:.::...
Mouse   140 GRVDKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNW-SGMDMKKAISYIRRS 203

  Fly   188 CNQTDGGFGSKPGAESHAGLIYCCVGFFSLTHRLHLL----DVDKLGWWLCERQLPSGGLNGRPE 248
            .:. |.|.....|.|||.|..:|.:....|..:|..:    :::::..|...||  ..|.:|||.
Mouse   204 MSY-DNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQ--QNGYHGRPN 265

  Fly   249 KLPDVCYSWWVLASLTIMGRLHWISSEKLQQFILSCQDTETGGFSDRTGNMPDIFHTLFGIGGLS 313
            |..|.|||:||.|:|.::....:.:.||.:.:|||.||...|||:....:.||..|..|||.|||
Mouse   266 KPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLS 330

  Fly   314 LLGHSGLKAINPTLCMPQYIIDRL 337
            |:..||:..::|.|.:.....:||
Mouse   331 LMEESGICKVHPALNVSTRTSERL 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
betaggt-II	NP_524894.1	GGTase-II	29..315	CDD:239224	92/320 (29%)
betaggt-II	NP_524894.1	PLN03201	33..340	CDD:215630	97/338 (29%)
Pggt1b	NP_766215.1	CAL1	21..360	CDD:227362	97/341 (28%)
		GGTase-I	22..332	CDD:239225	90/316 (28%)
		PFTB 1	144..186		15/41 (37%)
		PFTB 2	193..234		11/41 (27%)
		Geranylgeranyl diphosphate binding. /evidence=ECO:0000250\|UniProtKB:P53610	219..221		1/1 (100%)
		PFTB 3	245..284		16/40 (40%)
		Geranylgeranyl diphosphate binding. /evidence=ECO:0000250\|UniProtKB:P53610	263..266		2/2 (100%)
		Geranylgeranyl diphosphate binding. /evidence=ECO:0000250\|UniProtKB:P53610	272..275		2/2 (100%)
		PFTB 4	291..333		20/41 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1042804at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920