DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TTLL4A and TTLL4

DIOPT Version :9

Sequence 1:	NP_001162947.1	Gene:	TTLL4A / 47729	FlyBaseID:	FBgn0026147	Length:	1071	Species:	Drosophila melanogaster
Sequence 2:	XP_016860876.1	Gene:	TTLL4 / 9654	HGNCID:	28976	Length:	1226	Species:	Homo sapiens

Alignment Length:	1107	Identity:	335/1107 - (30%)
Similarity:	526/1107 - (47%)	Gaps:	217/1107 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 HNLPTKRIPTKQSARSSYHQS--------AANSAP-DSSLFTDAFGQQSLVNQRIAGNKSCEYVY 118
            |:||.....|....||||.|.        ...|:| :.|.|  :..|:||.....|...:...|:
Human   106 HSLPDLFNSTLLYRRSSYRQKPYQQLESFCLRSSPSEKSPF--SLPQKSLPVSLTANKATSSMVF 168

  Fly   119 QTVQRSEDQHSNRQYKQARSYAVDKEQQQQMLLQPSIVYFDA-ELKKRKDRGGRVSNDYVDNSPD 182
            ...|......:                      :|.:....| |....|.....:|.........
Human   169 SMAQPMASSST----------------------EPYLCLAAAGENPSGKSLASAISGKIPSPLSS 211

  Fly   183 RYRP-LNSPSPEPTWDNILSERPVQYQTTNQHYQHYFSYFYNRGAEKLSKPTFAAANSRKVPMSK 246
            .|:| ||:.|  ..|.|   ..||....|.|            |.:.:|.|...       |:|.
Human   212 SYKPMLNNNS--FMWPN---STPVPLLQTTQ------------GLKPVSPPKIQ-------PVSW 252

  Fly   247 FQKAGASRRDSREVD-------GTVIIGRRDNSEDRTWQGQKYEKHVLKEKLPSNDLKADYLDNG 304
            ....|......:.||       |||   ..|.|           .|:......|:|.....:.:.
Human   253 HHSGGTGDCAPQPVDHKVPKSIGTV---PADAS-----------AHIALSTASSHDTSTTSVASS 303

  Fly   305 W--------GGDPGSEDDYRDIKDSYDPVVVI----------DNGLEQVGVHRRYCRMTENTVLD 351
            |        ..:|.| ....|..||.||...|          ..|.|:  :.|:.|::.:::.|
Human   304 WYNRNNLAMRAEPLS-CALDDSSDSQDPTKEIRFTEAVRKLTARGFEK--MPRQGCQLEQSSFL- 364

  Fly   352 GSGDTLINNNNNELKIMRKSTDQPMPRLPMTPKRAKGGTVSTKKPMP---TVHRVLLYSTQSPRL 413
                    |.:.:..::.:|            :|.|...|:.:.|..   :|.|||  ...|..|
Human   365 --------NPSFQWNVLNRS------------RRWKPPAVNQQFPQEDAGSVRRVL--PGASDTL 407

  Fly   414 GRKQQ-FSTQRLSV---------------------------------------------KQQSSK 432
            |.... |.|:|:|:                                             .:.||.
Human   408 GLDNTVFCTKRISIHLLASHASGLNHNPACESVIDSSAFGEGKAPGPPFPQTLGIANVATRLSSI 472

  Fly   433 VLGAGDERQTVLLLEPEHKQEDHRSAIDFD----RNDDFDED--DDLDNLSNFDESDTASVLSDT 491
            .||..::.:.....|.:....|..||.|..    ..:|.:|:  |.|::..:.||::...  .|:
Human   473 QLGQSEKERPEEARELDSSDRDISSATDLQPDQAETEDTEEELVDGLEDCCSRDENEEEE--GDS 535

  Fly   492 EDGYRAHAFKLTHSVDRFSSPQSTPSFLSSQSSEDDLKNPDS--------LLVPSLFPYVPPYLS 548
            |          ..|:...|..:|..  :.|:|..:.|..|.|        .|:.||||.|||.:.
Human   536 E----------CSSLSAVSPSESVA--MISRSCMEILTKPLSNHEKVVRPALIYSLFPNVPPTIY 588

  Fly   549 FSSNTKRGPRVPPDLHRVLKWRITNIMPKVVRLILANSGMRMLKKTNDWMGVWGKHLKSPCFKAI 613
            |.:..:|..::|.:..::|:|:::.:.|.:|:..:..|..::.|:.:||:|.||.|:|||.|::|
Human   589 FGTRDERVEKLPWEQRKLLRWKMSTVTPNIVKQTIGRSHFKISKRNDDWLGCWGHHMKSPSFRSI 653

  Fly   614 RSYQKINHLPGSFRIGRKDSCWKNLQRQMGKHSNKEFGFMPRTYIIPNDLGALRRHWPKYAQRNT 678
            |.:||:||.||||:|||||..|:||.|...:...|||.|.|:::|:|.|...||:.|...:::
Human   654 REHQKLNHFPGSFQIGRKDRLWRNLSRMQSRFGKKEFSFFPQSFILPQDAKLLRKAWESSSRQ-- 716

  Fly   679 KWIIKPPASARGAGIRVINRWGQIPKRRPLIVQKYIERPLLINGSKFDLRLYVLVTSVNPLRVFM 743
            |||:||||||||.||:||::|.|:||||||:||:|:.:|.||:|||||||:||.|||.:|||:::
Human   717 KWIVKPPASARGIGIQVIHKWSQLPKRRPLLVQRYLHKPYLISGSKFDLRIYVYVTSYDPLRIYL 781

  Fly   744 YHNGLARFASVKYSAKTDTLNDRCMHLTNYSINKFSSNYSKNEDVNACHGHKWTIKSLWTYLANR 808
            :.:||.||||.|||....:|.::.|||||||:||.::.|..|.|..||.||||.:|:||.||:.:
Human   782 FSDGLVRFASCKYSPSMKSLGNKFMHLTNYSVNKKNAEYQANADEMACQGHKWALKALWNYLSQK 846

  Fly   809 GVRTDCLWEALRSLVLRTILAGENGINSMIRANVESKYSCFELFGFDVILDSDLVPWLLEVNISP 873
            ||.:|.:||.::.:|::||::.|..:.|:::..|...|||.||||||::||.:|.||:|||||||
Human   847 GVNSDAIWEKIKDVVVKTIISSEPYVTSLLKMYVRRPYSCHELFGFDIMLDENLKPWVLEVNISP 911

  Fly   874 SLHSELPLDAHVKAPLVQGVLNTALYNVPPKLSLDKQKE--LAAEFSFP--PGTQMCYDK-RLYI 933
            ||||..|||..:|..:::.:||.|.:.:|....:.....  .::..|.|  ||     || |:..
Human   912 SLHSSSPLDISIKGQMIRDLLNLAGFVLPNAEDIISSPSSCSSSTTSLPTSPG-----DKCRMAP 971

  Fly   934 NYLSREEKIKHNTFTRKSMEDRNEYVDAILNNLTPDDVRCLIIAEDELARCAPLERIFPTDQTHK 998
            .::: .:|:|...:..:.:.|::.|. ::|:.|||||||.|:..|||.:|....|||||:..:.:
Human   972 EHVT-AQKMKKAYYLTQKIPDQDFYA-SVLDVLTPDDVRILVEMEDEFSRRGQFERIFPSHISSR 1034

  Fly   999 YLKYNDTPRYYNRLLDAWESRYANNRTEGIALLRDYCQNKYHLQV--PTPPAKKDSNDEETTPAT 1061
            ||::.:.|||:|.|...||.:|..|:.:|:.|||.:|...:|:.|  .:.|....::.|:::.:.
Human  1035 YLRFFEQPRYFNILTTQWEQKYHGNKLKGVDLLRSWCYKGFHMGVVSDSAPVVSAASVEDSSFSG 1099

  Fly  1062 PN 1063
            |:
Human  1100 PS 1101

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TTLL4A	NP_001162947.1	TTL	614..908	CDD:281171	150/293 (51%)
TTLL4	XP_016860876.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146840
Domainoid	1	1.000	339	1.000	Domainoid score	I1097
eggNOG	1	0.900	-	-		E1_KOG2156
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	485	1.000	Inparanoid score	I1450
Isobase	1	0.950	-	0	Normalized mean entropy	S5103
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250453at33208
OrthoFinder	1	1.000	-	-		FOG0006381
OrthoInspector	1	1.000	-	-		otm41247
orthoMCL	1	0.900	-	-		OOG6_101354
Panther	1	1.100	-	-	LDO	PTHR12241
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2864
SonicParanoid	1	1.000	-	-		X4643
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.740