Protein Alignment TTLL4A and TTLL2

DIOPT Version :9

• Sequence 1: NP_001162947.1
• Gene: TTLL4A / 47729
• FlyBaseID: FBgn0026147
• Length: 1071
• Species: Drosophila melanogaster
• Sequence 2: NP_114155.4
• Gene: TTLL2 / 83887
• HGNCID: 21211
• Length: 592
• Species: Homo sapiens
• Alignment Length: 591
• Identity: 159/591 - (26%)
• Similarity: 250/591 - (42%)
• Gaps: 116/591 - (19%)

  Fly   507 DRFSSPQS---------TPSF-LSSQSSEDDLKNPDSLLVPSLFP---YVPPYLSFSSNT---KR 555
            |..||.||         ||:| |:..|..:..:.|.:.|...|..   .:||.....:.|   |:
Human     5 DLCSSTQSQALGSLRTTTPAFTLNIPSEANHTEQPPAGLGARLQEAGVSIPPRRGRPTPTLEKKK 69

  Fly   556 GPRVPPD------LHRVLKWRITNIMPKVVRLILANSGMRMLKKTNDWMGVWGKHLKSPCFK--- 611
            .|.:..:      |.:.|.:|:....|.||:.:|...|.....|.......|..:.::..|:
Human    70 KPHLMAEDEPSGALLKPLVFRVDETTPAVVQSVLLERGWNKFDKQEQNAEDWNLYWRTSSFRMTE 134

  Fly   612 --AIRSYQKINHLPGSFRIGRKDSCWKNLQRQMGKHSNKEFGFMPRTYIIPNDLGALRRHWPKYA 674
              :::.:|::||.||:.::.|||...|:|:.....:....:.|:|.|:::|||   ..:...:|.
Human   135 HNSVKPWQQLNHHPGTTKLTRKDCLAKHLKHMRRMYGTSLYQFIPLTFVMPND---YTKFVAEYF 196

  Fly   675 Q-------RNTKWIIKPPASARGAGIRVINRWGQIPKRRPLIVQKYIERPLLINGSKFDLRLYVL 732
            |       :::.||.||...:||.||.:.:.:.........||||||..||||...|.|||:||.
Human   197 QERQMLGTKHSYWICKPAELSRGRGILIFSDFKDFIFDDMYIVQKYISNPLLIGRYKCDLRIYVC 261

  Fly   733 VTSVNPLRVFMYHNGLARFASVKYSAKTDTLNDRCMHLTNYSINKFSSNYSKNEDVNACHGHKWT 797
            ||...||.:::|..||.|||:.|:.  ...|.:...||||.||||..::|.|.::|.. ||.|||
Human   262 VTGFKPLTIYVYQEGLVRFATEKFD--LSNLQNNYAHLTNSSINKSGASYEKIKEVIG-HGCKWT 323

  Fly   798 IKSLWTYLANRGVRTDCLWEALRSLVLRTILAGENGINSMIRANVESKYSCFELFGFDVILDSDL 862
            :...::||.:..|....||:.:..:|:.||||        |..:|....:||||||||:::|.:|
Human   324 LSRFFSYLRSWDVDDLLLWKKIHRMVILTILA--------IAPSVPFAANCFELFGFDILIDDNL 380

  Fly   863 VPWLLEVNISPSLHSELPLDAHVKAPLVQGVLNTALYNVPPKLSLDKQKELAAEFSFPPGTQMCY 927
            .|||||||.||:|..:...|..||..||..:::.
Human   381 KPWLLEVNYSPALTLDCSTDVLVKRKLVHDIIDL------------------------------- 414

  Fly   928 DKRLYINYLSREEKIKHNTFTRKSMEDRNEYVDAILNNL----TPDDVRCLIIAEDELARCAPLE 988
               :|:|.|..|.:...|.      ...|..:||..::.    .||              |.|.:
Human   415 ---IYLNGLRNEGREASNA------THGNSNIDAAKSDRGGLDAPD--------------CLPYD 456

  Fly   989 RIFPTDQTHKYLKYNDTPRYYNRLLDAWESRYANNRTEGIALLRDYCQNKYHLQVPTPPAKKDSN 1053
            .:..|.:     .||:......:.:.........::.||     :.....:||.....|..|...
Human   457 SLSFTSR-----MYNEDDSVVEKAVSVRPEAAPASQLEG-----EMSGQDFHLSTREMPQSKPKL 511

  Fly  1054 DEETTP 1059
            ....||
Human   512 RSRHTP 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TTLL4A	NP_001162947.1	TTL	614..908	CDD:281171	107/300 (36%)
TTLL2	NP_114155.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23		5/17 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	51..77		5/25 (20%)
		TTL	140..412	CDD:281171	107/285 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250453at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920