DRSC/TRiP Functional Genomics Resources

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Protein Alignment TTLL4A and TTLL7

DIOPT Version :9

Sequence 1:NP_001162947.1 Gene:TTLL4A / 47729 FlyBaseID:FBgn0026147 Length:1071 Species:Drosophila melanogaster
Sequence 2:NP_001337143.1 Gene:TTLL7 / 79739 HGNCID:26242 Length:887 Species:Homo sapiens


Alignment Length:606 Identity:168/606 - (27%)
Similarity:272/606 - (44%) Gaps:106/606 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   519 LSSQSSEDDLKNPDSLLVPSLFPYVPPYLSFSSNTKRGPRVPPDLHRVLKWRIT-NIMP---KVV 579
            :.|...|..::.|..|.:.:..||       .|..||..|     .:..|..|| |:..   ::|
Human     1 MPSLPQEGVIQGPSPLDLNTELPY-------QSTMKRKVR-----KKKKKGTITANVAGTKFEIV 53

  Fly   580 RLILANSGMRMLKKTNDWMG-VWGKHLKSPCFKAI--------RSYQKINHLPGSFRIGRKDSCW 635
            ||::...|.......::... :|       |..|:        ::||:|||.||...|.|||...
Human    54 RLVIDEMGFMKTPDEDETSNLIW-------CDSAVQQEKISELQNYQRINHFPGMGEICRKDFLA 111

  Fly   636 KNLQRQMGKHSNKEFGFMPRTYIIPNDLGALRRHWP--KYAQRNTKWIIKPPASARGAGIRVINR 698
            :|:.: |.|....::.|:|||:|.|.:....:.:..  |..::...:|:||...|.|.||.:|..
Human   112 RNMTK-MIKSRPLDYTFVPRTWIFPAEYTQFQNYVKELKKKRKQKTFIVKPANGAMGHGISLIRN 175

  Fly   699 WGQIPKRRPLIVQKYIERPLLINGSKFDLRLYVLVTSVNPLRVFMYHNGLARFASVKYSAKTDT- 762
            ..::|.:..||||:|||:|.|:.|.|||||:|:||||.:||::|:||:||.|..:.||....:: 
Human   176 GDKLPSQDHLIVQEYIEKPFLMEGYKFDLRIYILVTSCDPLKIFLYHDGLVRMGTEKYIPPNESN 240

  Fly   763 LNDRCMHLTNYSINKFSSNYSKNEDVNACHGHKWTIKSLWTYLANRGVRTDCLWEALRSLVLRTI 827
            |....|||||||:||.:.::.::|..|  .|.|.:||....:|..........|..:..||::|:
Human   241 LTQLYMHLTNYSVNKHNEHFERDETEN--KGSKRSIKWFTEFLQANQHDVAKFWSDISELVVKTL 303

  Fly   828 LAGENGI---NSMIRANVE--SKYSCFELFGFDVILDSDLVPWLLEVNISPSLHSELPLDAHVKA 887
            :..|..:   ..|.|....  |:..|||:.|||::||..|.|||||:|.:||..::..:|..|| 
Human   304 IVAEPHVLHAYRMCRPGQPPGSESVCFEVLGFDILLDRKLKPWLLEINRAPSFGTDQKIDYDVK- 367

  Fly   888 PLVQGVLNTALYNVPPKLSLDKQKELAAEFS--------------FPPGTQMCYDKRLYINYLSR 938
               :|||..||..:..:.| ||::.||.:.:              ..||:.....:|..:.  .|
Human   368 ---RGVLLNALKLLNIRTS-DKRRNLAKQKAEAQRRLYGQNSIKRLLPGSSDWEQQRHQLE--RR 426

  Fly   939 EEKIKHNTFTRKSMEDRNEYVDAILNN----LTPDDVRCLIIAEDELA---------RCAPLERI 990
            :|::|......:....|.|:.:..:.|    ..|:|...|...|:.||         |.|..:| 
Human   427 KEELKERLAQVRKQISREEHENRHMGNYRRIYPPEDKALLEKYENLLAVAFQTFLSGRAASFQR- 490

  Fly   991 FPTDQTHKYLKYNDTPRYYNRLLDAWESRYANN--------RTEG------------IALLRDYC 1035
             ..:...|.:|..|       :||..|....::        :|.|            |.....||
Human   491 -ELNNPLKRMKEED-------ILDLLEQCEIDDEKLMGKTTKTRGPKPLCSMPESTEIMKRPKYC 547

  Fly  1036 QNKYHLQVPTPPAKKDSNDEE 1056
            .:.......:..::.|.|::|
Human   548 SSDSSYDSSSSSSESDENEKE 568

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TTLL4ANP_001162947.1 TTL 614..908 CDD:281171 111/301 (37%)
TTLL7NP_001337143.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21 4/19 (21%)
TTL 91..376 CDD:281171 109/291 (37%)
SMC_N <373..>518 CDD:330553 31/156 (20%)
DUF2570 <383..>448 CDD:329230 13/67 (19%)
c-MTBD region. /evidence=ECO:0000269|PubMed:25959773 388..450 10/63 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 519..621 8/50 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 651..676
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D250453at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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