DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TTLL4A and Ttll11

DIOPT Version :9

Sequence 1:	NP_001162947.1	Gene:	TTLL4A / 47729	FlyBaseID:	FBgn0026147	Length:	1071	Species:	Drosophila melanogaster
Sequence 2:	NP_084050.1	Gene:	Ttll11 / 74410	MGIID:	1921660	Length:	727	Species:	Mus musculus

Alignment Length:	457	Identity:	130/457 - (28%)
Similarity:	210/457 - (45%)	Gaps:	104/457 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   618 KINHLPGSFRIGRKDSCWKNLQRQMGKHSNKEFGFMPRTYIIPNDLGALRRHWPKYAQRNTKW-- 680
            ::|..||...:.||.:..:.| |.|.....:|:.|.||::|:|.:............:.:..|
Mouse   178 QVNKFPGMTEMVRKVTLSRAL-RIMQNLFPEEYNFYPRSWILPEEFQLFVSQVQTVKEGDPSWKP 241

  Fly   681 --IIKPPASARGAGIRVI-----NRWGQIPKRRPLIVQKYIERPLLINGSKFDLRLYVLVTSVNP 738
              |:||.:..:|.||.:|     .|.......||.:||:||.:||||:..|||:|||||:.|::|
Mouse   242 TFIVKPDSGCQGDGIYLIKDPCDGRLTGTLHNRPAVVQEYIRKPLLIDKLKFDIRLYVLLKSLDP 306

  Fly   739 LRVFMYHNGLARFASVKY-SAKTDTLNDRCMHLTNYSINKFSSNYSKNEDVNACHGHKWTIKSLW 802
            |.:::..:||:||.:..| ......|:...|||||||:|..|..:..::  :|..|.|.|..|:.
Mouse   307 LEIYIAKDGLSRFCTEPYQEPNPQNLHHVFMHLTNYSLNIHSGKFVHSD--SASTGSKRTFSSIL 369

  Fly   803 TYLANRGVRTDCLWEALRSLVLRTILAGENGINSMIRANVESKY---SCFELFGFDVILDSDLVP 864
            ..|:::||....:|..:.|||::|::|....:....::::.:..   :||::.|||::|..:|.|
Mouse   370 CRLSSKGVDIKKVWSDIISLVIKTVIALTPELKVFYQSDIPTGRPGPTCFQILGFDILLMKNLKP 434

  Fly   865 WLLEVNISPSLHSE------------LP--LDAHVKAPLVQGVLNTALYNVPPKLSLDKQKELAA 915
            .|||||.:||:..|            :|  :|..||..:::..|..    :.|   |.|:||:
Mouse   435 MLLEVNANPSMRIEHEYELSPGVFENIPSLVDEEVKVAVIRDTLRL----MDP---LKKKKEI-- 490

  Fly   916 EFSFPPGTQMCYDKRLYINYLSREEKI----------KH--------------NTFTRKSMEDRN 956
              .||.            .|:.|:.:|          ||              .:||.|  ||.|
Mouse   491 --HFPD------------IYMDRKHRIPPVSDRMSSWKHKGSSLSIVRSQQMEKSFTSK--EDLN 539

  Fly   957 EYVDAILNNLTPDDVRCLIIAEDELARCAPLERIFPTDQTHKYLK-YNDTPRYYNRLLDAWESRY 1020
              .|....:..|:       .|..|.... |:::||     ||.| :|     |.||:|    |.
Mouse   540 --CDPTGGDSEPN-------PEAHLPSIC-LKQVFP-----KYAKQFN-----YLRLVD----RM 580

  Fly  1021 AN 1022
            ||
Mouse   581 AN 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TTLL4A	NP_001162947.1	TTL	614..908	CDD:281171	95/316 (30%)
Ttll11	NP_084050.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..88
		ATP-grasp_4	178..445	CDD:302634	87/269 (32%)
		c-MTBD region. /evidence=ECO:0000250\|UniProtKB:Q8NHH1	464..566		29/141 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	530..551		8/31 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	694..727
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250453at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920