Protein Alignment TTLL4A and Ttll4

DIOPT Version :10

• Sequence 1: NP_723642.2
• Gene: TTLL4A / 47729
• FlyBaseID: FBgn0026147
• Length: 1071
• Species: Drosophila melanogaster
• Sequence 2: NP_001014974.1
• Gene: Ttll4 / 67534
• MGIID: 1914784
• Length: 1193
• Species: Mus musculus
• Alignment Length: 1186
• Identity: 346/1186 - (29%)
• Similarity: 542/1186 - (45%)
• Gaps: 262/1186 - (22%)

  Fly    19 GAPA--------SRYCNADNTFCYYSYDN-CNL--IAPAWGN-----RQNQNQ-----------N 56
            |.|:        |..|::..|.....:.| |.|  :...:.|     |.|..|           .
Mouse    73 GVPSQPAYFLCPSTLCSSGTTAVIAGHSNPCYLQSLPNLFSNTLLYRRTNVRQKPYQQLESFCLR 137

  Fly    57 SVPNQ--NHNLPTKRIP---TKQSARSS----YHQSAANSAPDSSLFTDAFGQ----QSLVNQRI 108
            |.|::  :.:||.|.:|   |...|.||    ..|..|.|..|..|...|.|:    :||.: .|
Mouse   138 SSPSEKRSFSLPQKGLPVSVTANKATSSTVFPMAQPMATSPTDPYLSLAAAGENPSRKSLAS-AI 201

  Fly   109 AGNKSCEYVYQTVQRSEDQHSNRQYKQARSYAVDKEQQQQML-------LQPSIVYFDAELKKRK 166
            :|..:....|:.:.      :|..:.:..|..|...|....|       :||...:..
Mouse   202 SGKIASPLSYKPML------NNNSFMRPNSTKVPLSQATDGLKPVSSPKIQPVSWHHS------- 253

  Fly   167 DRGGRVSNDYVDNSPDRYRPLN------------SPSPEPTWDNILSERPVQYQTTNQHYQ---H 216
              ||  :.|.|....|...|.|            :|| .|:..||.:......|.:..:::   |
Mouse   254 --GG--TGDCVPQPGDHKVPQNIATVLDDVTAPITPS-IPSTLNISTASVTSSQCSQSNFRMEAH 313

  Fly   217 YFSYFYNRGAEKLSKPTFAAANSRKVP---MSKFQKAGASRRDSREVDGTVIIGRRDNSEDRTWQ 278
            ......|..::..:|........||:.   :.|..:.|.....:..|:.:...|..:.|  |.|
Mouse   314 PCGLDENPDSQSATKEVHFTEAVRKLAEKGLEKMPRQGYQFEQACFVNPSFQWGLLNRS--RRW- 375

  Fly   279 GQKYEKHVLKEKLPSNDLKADYLDNGWGGDPGSEDDYRDIKDSYDPVVVIDNGLEQVGVHRRYCR 343
                 |.::.::.|..|:..|
Mouse   376 -----KPLMGQRFPQEDIGLD-------------------------------------------- 391

  Fly   344 MTENTVLDGSGDTLINNNNNELKIMRKSTDQPMPRLPMTPKRAKGGTVSTKKPMPTVHRVLLYS- 407
               :.:|.|:.|||                            ....||...|.: ::|  ||.|
Mouse   392 ---SAILPGTSDTL----------------------------GLDSTVFCTKRI-SIH--LLASH 422

  Fly   408 ----TQSPRLGR---KQQFSTQRLSVKQQSSKVLGAGD---ERQTVLLLEPEHKQEDHR------ 456
                ..||..|.   .|.....|..|...|.:.||..:   ...:|.|.:|..:.|:.:
Mouse   423 VHGLNPSPACGSAVDPQVLGEDRAPVPPSSLQPLGVAEVATRLSSVHLDQPGKEPEEAKDLNSCT 487

  Fly   457 ----SAIDFDRNDDFDED------DDLDNLSNFDESD---------TASVLSDTEDGYRAHAFKL 502
                ||.|...|....||      |.|::..:.||::         :.||:|.:|    :.|...
Mouse   488 KGGGSATDLQPNQVEPEDTEDELGDGLEDSCSHDENEEEEGDSECSSLSVVSPSE----SVALIS 548

  Fly   503 THSVDRFSSPQSTPSFLSSQSSEDDLKNPDSLLVPSLFPYVPPYLSFSSNTKRGPRVPPDLHRVL 567
            .:.||           |.|:|..:..|.....|:.||||.|.|.:.|.:..:|..::|.:..|:|
Mouse   549 RNCVD-----------LMSKSLPNHEKVVRPALIYSLFPNVTPTIYFGTRDERVEKLPWEQRRLL 602

  Fly   568 KWRITNIMPKVVRLILANSGMRMLKKTNDWMGVWGKHLKSPCFKAIRSYQKINHLPGSFRIGRKD 632
            :|:::.:.|.:|:..:..|..::.|:.:||:|.||.|:|||.|::||.:||:||.||||:|||||
Mouse   603 RWKMSTVTPNIVKQTIGRSHFKISKRNDDWLGCWGHHMKSPGFRSIREHQKLNHFPGSFQIGRKD 667

  Fly   633 SCWKNLQRQMGKHSNKEFGFMPRTYIIPNDLGALRRHWPKYAQRNTKWIIKPPASARGAGIRVIN 697
            ..|:||.|...:...|||.|.|:::|:|.|...||:.|...:::  |||:||||||||.||:||:
Mouse   668 RLWRNLSRMQSRFGKKEFSFFPQSFILPQDSKLLRKAWESSSRQ--KWIVKPPASARGIGIQVIH 730

  Fly   698 RWGQIPKRRPLIVQKYIERPLLINGSKFDLRLYVLVTSVNPLRVFMYHNGLARFASVKYSAKTDT 762
            :|.|:||||||:||:|:.:|.||:|||||||:||.|||.:|||::::.:||.||||.|||....:
Mouse   731 KWSQLPKRRPLLVQRYLHKPYLISGSKFDLRIYVYVTSYDPLRIYLFSDGLVRFASCKYSPSMKS 795

  Fly   763 LNDRCMHLTNYSINKFSSNYSKNEDVNACHGHKWTIKSLWTYLANRGVRTDCLWEALRSLVLRTI 827
            |:::.|||||||:||.::.|..|.|..||.||||.:|:||.||:.:|:.:|.:||.::.:|::||
Mouse   796 LSNKFMHLTNYSVNKKNTEYQANADETACQGHKWALKALWNYLSQKGINSDAIWEKIKDVVVKTI 860

  Fly   828 LAGENGINSMIRANVESKYSCFELFGFDVILDSDLVPWLLEVNISPSLHSELPLDAHVKAPLVQG 892
            ::.|..:.::::..|...|||.||||||::||.:|.||:|||||||||||..|||..:|..:::.
Mouse   861 ISSEPYVTNLLKLYVRRPYSCHELFGFDIMLDENLKPWVLEVNISPSLHSNSPLDISIKGQMIRD 925

  Fly   893 VLNTALYNVPP-----KLSLDKQKELAAEFSFPPGTQMCYDKRLYINYLSREEKIKHNTFTRKSM 952
            :||.|.:.:|.     ..|........:..|.|...:   ||..........:|:|...:..:.:
Mouse   926 LLNLAGFVLPNMEDIISSSSSPSSSSGSSTSLPSSPR---DKCQMTPEHFTAQKMKKAYYLTQKI 987

  Fly   953 EDRNEYVDAILNNLTPDDVRCLIIAEDELARCAPLERIFPTDQTHKYLKYNDTPRYYNRLLDAWE 1017
            .|::.|. ::|:.|||||||.|:..|||.:|....|||||:..:.:||::.:.|||:|.|...||
Mouse   988 PDQDFYA-SVLDVLTPDDVRVLVEMEDEFSRRGQFERIFPSRISSRYLRFFEQPRYFNILTTQWE 1051

  Fly  1018 SRYANNRTEGIALLRDYCQNKYHL----------QVPT---------------PPAKKDSNDEET 1057
            .:|..|:.:|:.|||::|...:|.          .:||               ..::|.|..|.|
Mouse  1052 QKYHGNKLKGVDLLRNWCYKGFHTGIVSDSAPLWSLPTSLMTTSKGDGTPNSASKSRKKSASEGT 1116

  Fly  1058 T-----PATPNTVKEE 1068
            |     .:||.:.|.:
Mouse  1117 TLSSEDRSTPKSKKSQ 1132

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TTLL4A	NP_723642.2	TTL	614..909	CDD:397308	149/299 (50%)
Ttll4	NP_001014974.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..37
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	468..535		14/66 (21%)
		TTL	649..941	CDD:397308	148/293 (51%)
		c-MTBD region. /evidence=ECO:0000250|UniProtKB:Q14679	913..1027		34/117 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	943..966		5/25 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1092..1193		8/41 (20%)