DRSC/TRiP Functional Genomics Resources

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Protein Alignment TTLL4A and Ttll4

DIOPT Version :9

Sequence 1:NP_001162947.1 Gene:TTLL4A / 47729 FlyBaseID:FBgn0026147 Length:1071 Species:Drosophila melanogaster
Sequence 2:NP_001014974.1 Gene:Ttll4 / 67534 MGIID:1914784 Length:1193 Species:Mus musculus


Alignment Length:1186 Identity:346/1186 - (29%)
Similarity:542/1186 - (45%) Gaps:262/1186 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 GAPA--------SRYCNADNTFCYYSYDN-CNL--IAPAWGN-----RQNQNQ-----------N 56
            |.|:        |..|::..|.....:.| |.|  :...:.|     |.|..|           .
Mouse    73 GVPSQPAYFLCPSTLCSSGTTAVIAGHSNPCYLQSLPNLFSNTLLYRRTNVRQKPYQQLESFCLR 137

  Fly    57 SVPNQ--NHNLPTKRIP---TKQSARSS----YHQSAANSAPDSSLFTDAFGQ----QSLVNQRI 108
            |.|::  :.:||.|.:|   |...|.||    ..|..|.|..|..|...|.|:    :||.: .|
Mouse   138 SSPSEKRSFSLPQKGLPVSVTANKATSSTVFPMAQPMATSPTDPYLSLAAAGENPSRKSLAS-AI 201

  Fly   109 AGNKSCEYVYQTVQRSEDQHSNRQYKQARSYAVDKEQQQQML-------LQPSIVYFDAELKKRK 166
            :|..:....|:.:.      :|..:.:..|..|...|....|       :||...:..       
Mouse   202 SGKIASPLSYKPML------NNNSFMRPNSTKVPLSQATDGLKPVSSPKIQPVSWHHS------- 253

  Fly   167 DRGGRVSNDYVDNSPDRYRPLN------------SPSPEPTWDNILSERPVQYQTTNQHYQ---H 216
              ||  :.|.|....|...|.|            :|| .|:..||.:......|.:..:::   |
Mouse   254 --GG--TGDCVPQPGDHKVPQNIATVLDDVTAPITPS-IPSTLNISTASVTSSQCSQSNFRMEAH 313

  Fly   217 YFSYFYNRGAEKLSKPTFAAANSRKVP---MSKFQKAGASRRDSREVDGTVIIGRRDNSEDRTWQ 278
            ......|..::..:|........||:.   :.|..:.|.....:..|:.:...|..:.|  |.| 
Mouse   314 PCGLDENPDSQSATKEVHFTEAVRKLAEKGLEKMPRQGYQFEQACFVNPSFQWGLLNRS--RRW- 375

  Fly   279 GQKYEKHVLKEKLPSNDLKADYLDNGWGGDPGSEDDYRDIKDSYDPVVVIDNGLEQVGVHRRYCR 343
                 |.::.::.|..|:..|                                            
Mouse   376 -----KPLMGQRFPQEDIGLD-------------------------------------------- 391

  Fly   344 MTENTVLDGSGDTLINNNNNELKIMRKSTDQPMPRLPMTPKRAKGGTVSTKKPMPTVHRVLLYS- 407
               :.:|.|:.|||                            ....||...|.: ::|  ||.| 
Mouse   392 ---SAILPGTSDTL----------------------------GLDSTVFCTKRI-SIH--LLASH 422

  Fly   408 ----TQSPRLGR---KQQFSTQRLSVKQQSSKVLGAGD---ERQTVLLLEPEHKQEDHR------ 456
                ..||..|.   .|.....|..|...|.:.||..:   ...:|.|.:|..:.|:.:      
Mouse   423 VHGLNPSPACGSAVDPQVLGEDRAPVPPSSLQPLGVAEVATRLSSVHLDQPGKEPEEAKDLNSCT 487

  Fly   457 ----SAIDFDRNDDFDED------DDLDNLSNFDESD---------TASVLSDTEDGYRAHAFKL 502
                ||.|...|....||      |.|::..:.||::         :.||:|.:|    :.|...
Mouse   488 KGGGSATDLQPNQVEPEDTEDELGDGLEDSCSHDENEEEEGDSECSSLSVVSPSE----SVALIS 548

  Fly   503 THSVDRFSSPQSTPSFLSSQSSEDDLKNPDSLLVPSLFPYVPPYLSFSSNTKRGPRVPPDLHRVL 567
            .:.||           |.|:|..:..|.....|:.||||.|.|.:.|.:..:|..::|.:..|:|
Mouse   549 RNCVD-----------LMSKSLPNHEKVVRPALIYSLFPNVTPTIYFGTRDERVEKLPWEQRRLL 602

  Fly   568 KWRITNIMPKVVRLILANSGMRMLKKTNDWMGVWGKHLKSPCFKAIRSYQKINHLPGSFRIGRKD 632
            :|:::.:.|.:|:..:..|..::.|:.:||:|.||.|:|||.|::||.:||:||.||||:|||||
Mouse   603 RWKMSTVTPNIVKQTIGRSHFKISKRNDDWLGCWGHHMKSPGFRSIREHQKLNHFPGSFQIGRKD 667

  Fly   633 SCWKNLQRQMGKHSNKEFGFMPRTYIIPNDLGALRRHWPKYAQRNTKWIIKPPASARGAGIRVIN 697
            ..|:||.|...:...|||.|.|:::|:|.|...||:.|...:::  |||:||||||||.||:||:
Mouse   668 RLWRNLSRMQSRFGKKEFSFFPQSFILPQDSKLLRKAWESSSRQ--KWIVKPPASARGIGIQVIH 730

  Fly   698 RWGQIPKRRPLIVQKYIERPLLINGSKFDLRLYVLVTSVNPLRVFMYHNGLARFASVKYSAKTDT 762
            :|.|:||||||:||:|:.:|.||:|||||||:||.|||.:|||::::.:||.||||.|||....:
Mouse   731 KWSQLPKRRPLLVQRYLHKPYLISGSKFDLRIYVYVTSYDPLRIYLFSDGLVRFASCKYSPSMKS 795

  Fly   763 LNDRCMHLTNYSINKFSSNYSKNEDVNACHGHKWTIKSLWTYLANRGVRTDCLWEALRSLVLRTI 827
            |:::.|||||||:||.::.|..|.|..||.||||.:|:||.||:.:|:.:|.:||.::.:|::||
Mouse   796 LSNKFMHLTNYSVNKKNTEYQANADETACQGHKWALKALWNYLSQKGINSDAIWEKIKDVVVKTI 860

  Fly   828 LAGENGINSMIRANVESKYSCFELFGFDVILDSDLVPWLLEVNISPSLHSELPLDAHVKAPLVQG 892
            ::.|..:.::::..|...|||.||||||::||.:|.||:|||||||||||..|||..:|..:::.
Mouse   861 ISSEPYVTNLLKLYVRRPYSCHELFGFDIMLDENLKPWVLEVNISPSLHSNSPLDISIKGQMIRD 925

  Fly   893 VLNTALYNVPP-----KLSLDKQKELAAEFSFPPGTQMCYDKRLYINYLSREEKIKHNTFTRKSM 952
            :||.|.:.:|.     ..|........:..|.|...:   ||..........:|:|...:..:.:
Mouse   926 LLNLAGFVLPNMEDIISSSSSPSSSSGSSTSLPSSPR---DKCQMTPEHFTAQKMKKAYYLTQKI 987

  Fly   953 EDRNEYVDAILNNLTPDDVRCLIIAEDELARCAPLERIFPTDQTHKYLKYNDTPRYYNRLLDAWE 1017
            .|::.|. ::|:.|||||||.|:..|||.:|....|||||:..:.:||::.:.|||:|.|...||
Mouse   988 PDQDFYA-SVLDVLTPDDVRVLVEMEDEFSRRGQFERIFPSRISSRYLRFFEQPRYFNILTTQWE 1051

  Fly  1018 SRYANNRTEGIALLRDYCQNKYHL----------QVPT---------------PPAKKDSNDEET 1057
            .:|..|:.:|:.|||::|...:|.          .:||               ..::|.|..|.|
Mouse  1052 QKYHGNKLKGVDLLRNWCYKGFHTGIVSDSAPLWSLPTSLMTTSKGDGTPNSASKSRKKSASEGT 1116

  Fly  1058 T-----PATPNTVKEE 1068
            |     .:||.:.|.:
Mouse  1117 TLSSEDRSTPKSKKSQ 1132

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TTLL4ANP_001162947.1 TTL 614..908 CDD:281171 149/298 (50%)
Ttll4NP_001014974.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..37
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 468..535 14/66 (21%)
TTL 649..941 CDD:281171 148/293 (51%)
c-MTBD region. /evidence=ECO:0000250|UniProtKB:Q14679 913..1027 34/117 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 943..966 5/25 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1092..1193 8/41 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167836791
Domainoid 1 1.000 340 1.000 Domainoid score I1090
eggNOG 1 0.900 - - E1_KOG2156
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 475 1.000 Inparanoid score I1477
Isobase 1 0.950 - 0 Normalized mean entropy S5103
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0006381
OrthoInspector 1 1.000 - - otm43307
orthoMCL 1 0.900 - - OOG6_101354
Panther 1 1.100 - - LDO PTHR12241
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2864
SonicParanoid 1 1.000 - - X4643
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1312.730

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