DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TTLL4A and TTLL5

DIOPT Version :9

Sequence 1:	NP_001162947.1	Gene:	TTLL4A / 47729	FlyBaseID:	FBgn0026147	Length:	1071	Species:	Drosophila melanogaster
Sequence 2:	NP_001287520.1	Gene:	TTLL5 / 43015	FlyBaseID:	FBgn0051108	Length:	917	Species:	Drosophila melanogaster

Alignment Length:	773	Identity:	209/773 - (27%)
Similarity:	343/773 - (44%)	Gaps:	154/773 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   367 IMRKSTDQPMPRLPMTPKRAKGGTVSTK----KPMPTVHRVLLYSTQSPRLGRKQQFSTQRLSVK 427
            :.|.:...|..|..::.|.:......||    ||:           |||     |:.:.:..:..
  Fly    38 VFRTNILNPKIRKTLSEKSSAQVLTDTKDNEEKPV-----------QSP-----QKLAEEEPTSS 86

  Fly   428 QQSSKVLGAGDERQTVLLLEPEHKQEDHRSAIDFDRNDDFDEDDDLDNLSN-FDESDTASVLSDT 491
            :.|||...:|..:|.:.||:...:         .|::|..........:.| :..||| |:.|:.
  Fly    87 EPSSKEALSGSTQQKIFLLKKPQQ---------CDKSDKLTFSSPFKKILNRYSSSDT-SISSEG 141

  Fly   492 EDGYRAHAFKLTHSVDRFSSPQSTPSFLSSQSSEDDLKNPDSLLVPSLFPYVPPYLSFSS----- 551
            |              :..:|.::....|.:..:..::|....|...|.:..:.|..:.|:
  Fly   142 E--------------EPANSSENKSRVLKTSQNAINIKLATDLSNESGYESIAPAKTISNTEVIE 192

  Fly   552 ---------NTKRGPRVPPDLHRVLKWRITNIMPKVVRLILANSGMRMLKKTND-----WMGVWG 602
                     :.:.|..:|....:: .::......|::|.:....|:..::..|:     |.||
  Fly   193 EDQEETSEDDAECGINMPASKLKI-TYKFHQTETKLLRKLFNVHGLTEVQGENNNFNLLWTGV-- 254

  Fly   603 KHLKSPCFKAIRSYQKINHLPGSFRIGRKDSCWKNLQRQMGKHSNKEFGFMPRTYIIP---NDL- 663
             |:|....:.:..||::||.|.|:.:.|||..:||::|.......|.|..:|:|:::|   .||
  Fly   255 -HMKLDIVRNLAPYQRVNHFPRSYEMTRKDRLYKNIERMQHLRGMKHFDIVPQTFVLPIESRDLV 318

  Fly   664 GALRRHWPKYAQRNTKWIIKPPASARGAGIRVINRWGQIPKRRPLIVQKYIERPLLINGSKFDLR 728
            .|..:|       ...||:||.||:||.||.::|...|||:....:|.|||..||.|:|.|.|||
  Fly   319 VAHNKH-------RGPWIVKPAASSRGRGIFIVNSPDQIPQDEQAVVSKYIVDPLCIDGHKCDLR 376

  Fly   729 LYVLVTSVNPLRVFMYHNGLARFASVKYSAKTDTLNDRCMHLTNYSINKFSSNY-----SKNEDV 788
            :||||||.:||.:::|..|:.|.|:|||....|.|.:.||||.||||||:.|:|     :::|||
  Fly   377 VYVLVTSFDPLIIYLYEEGIVRLATVKYDRHADNLWNPCMHLCNYSINKYHSDYIRSSDAQDEDV 441

  Fly   789 NACHGHKWTIKSLWTYLANRGVRTDCLWEALRSLVLRTILAGENGINSMIRANVESKYSCFELFG 853
                |||||:.:|..:|..:...|..|...:..|:::.:||....|.|..|..|.:..:||||:|
  Fly   442 ----GHKWTLSALLRHLKLQSCDTRQLMLNIEDLIIKAVLACAQSIISACRMFVPNGNNCFELYG 502

  Fly   854 FDVILDSDLVPWLLEVNISPSLHSELPLDAHVKAPLVQGVLNTALYNVPPKLSLDKQKELAAEFS 918
            ||:::|:.|.|||||:|:|||:..:.|||..||:.|:..:|...  .:|               :
  Fly   503 FDILIDNALKPWLLEINLSPSMGVDSPLDTKVKSCLMADLLTCV--GIP---------------A 550

  Fly   919 FPPGTQMCYDKRLYINYLSREEKIKHNTFTRKSME-DRNEYVDAILN-NLTPDDVRCLIIAEDEL 981
            :.|..:..||::......|..::|.  ||...|.: .:::...|.:| |||.::.|.|..|..:.
  Fly   551 YSPEMKSHYDQKWSRFRSSSCQRIA--TFPSTSQKTKKSKKKGAAINLNLTGEEQRILRNARLQY 613

  Fly   982 ARCAPLERIFPTDQT-HKYLKYND--------TPRY-------------YNRLL-------DAWE 1017
            :|.....||||||.: .:|..:.|        ||..             ||::|       |..:
  Fly   614 SRRGGFVRIFPTDDSMQRYGNFLDSANGIPISTPNVQSQTFQTPIIQHNYNQMLHQNLYSKDGRQ 678

  Fly  1018 SRYANNRTEGIALLRDYCQNKYHLQVPTPPA----------------KKDSNDEETTP 1059
            .:..||..:.|.......:....:.....|.                ||.||..|.||
  Fly   679 KQDDNNEADRIWQYERALETDSEIPFVKKPTVEKCEVEGRRLRKIMLKKISNGSELTP 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TTLL4A	NP_001162947.1	TTL	614..908	CDD:281171	121/302 (40%)
TTLL5	NP_001287520.1	TTL	266..549	CDD:281171	120/295 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450537
Domainoid	1	1.000	75	1.000	Domainoid score	I2480
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250453at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101354
Panther	1	1.100	-	-	P	PTHR12241
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.850