DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TTLL4A and TTLL4B

DIOPT Version :9

Sequence 1:	NP_001162947.1	Gene:	TTLL4A / 47729	FlyBaseID:	FBgn0026147	Length:	1071	Species:	Drosophila melanogaster
Sequence 2:	NP_001260010.1	Gene:	TTLL4B / 33609	FlyBaseID:	FBgn0031574	Length:	989	Species:	Drosophila melanogaster

Alignment Length:	903	Identity:	402/903 - (44%)
Similarity:	543/903 - (60%)	Gaps:	102/903 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   231 KPTFAAAN-------SRKVPMSKFQKAGASRRDSREVDGTVIIGRRDNSEDRTWQGQKY------ 282
            :|..||.|       ....|..:....|.|...:...|..        |...:..|||.
  Fly    85 QPHLAAPNRNHGRIVQSSTPQHRSSAGGGSAAGATASDSV--------SARYSPPGQKQRSPPSP 141

  Fly   283 EKHVLKEKLPSNDLKADYLDNGWGGDP---------GSEDDYRDIKDSYDP--VVVIDNGLEQVG 336
            .|.:..||:.:       |..|.||..         |:..:....|.:..|  |.|:.|.:.|..
  Fly   142 RKRLTPEKVAN-------LGGGGGGSKVGAQRIIIRGTPPNSSTPKVAATPSNVPVVANSVLQSE 199

  Fly   337 VHRRYCRMTENTVLDG-----SGDTLINNNNNELKIMRKSTDQPMPRLPMTPKRAKGGTVSTKKP 396
            .:::...:.:....:.     :|::..|.|.     .::|...|..:..:.|......:..|.||
  Fly   200 PYKKVQMLLKRAREEAFAKHTAGNSAANGNG-----PKRSAHSPPIQAKVPPSNMSCPSTQTLKP 259

  Fly   397 MPTVHRVLLYSTQSPRLGRKQQFSTQRLSVKQQSSKVLGAGDERQTVLLLE-----PEHKQE--- 453
            .|....|:.....|..|..:||....||..:...:|  .|....:|.|...     |::.|.
  Fly   260 SPPSKIVVNSFHGSSMLSTQQQEEKSRLLTQNGLTK--SAATALETSLYASLYANAPQNSQPQFH 322

  Fly   454 -------DHRSAI-----------DFDRNDDFDEDDDLDNLSNFDESDTASVLSDT-----EDGY 495
                   ||.::.           |.||..:.|....:|:::.:|:||:......|     ||..
  Fly   323 SPRISGGDHVASYVGVSLNKGAGHDNDRKHEDDPCAAIDDINYYDDSDSEEEYVGTPFFLEEDNT 387

  Fly   496 RAHAFKLTHSVDRFSSPQSTPSFLSSQSSEDDLK---NPDSLLVPSLFPYVPPYLSFSSNTKRGP 557
            .....|.|..:     ||.|||..|.::::.:..   .|:::|.|||||:|||||:|:|:..:||
  Fly   388 ETRQSKHTRLL-----PQKTPSKESVRTTDSEASVYFRPEAILSPSLFPHVPPYLNFTSHADKGP 447

  Fly   558 RVPPDLHRVLKWRITNIMPKVVRLILANSGMRMLKKTNDWMGVWGKHLKSPCFKAIRSYQKINHL 622
            .:|..|||||||:::.:|||:|:.::.|||.|::|.|.|||.||.||:|||.|:.|||:||.||:
  Fly   448 PMPAALHRVLKWKLSPVMPKIVKRVVLNSGFRIIKNTTDWMAVWEKHMKSPGFRTIRSHQKYNHI 512

  Fly   623 PGSFRIGRKDSCWKNLQRQMGKHSNKEFGFMPRTYIIPNDLGALRRHWPKYAQRNTKWIIKPPAS 687
            ||||||||||:.|:::...|.|...||||||.::||:|:||.:||:.|||.|.:.||||:|||||
  Fly   513 PGSFRIGRKDTMWRSIYNNMKKFGKKEFGFMQKSYIMPDDLESLRQVWPKNASKLTKWIVKPPAS 577

  Fly   688 ARGAGIRVINRWGQIPKRRPLIVQKYIERPLLINGSKFDLRLYVLVTSVNPLRVFMYHNGLARFA 752
            |||.|||::|:|.|.||.|||:||||||||||||.:|||:||||::||:||||::||.:||||||
  Fly   578 ARGTGIRIVNKWSQFPKDRPLVVQKYIERPLLINDNKFDMRLYVVLTSINPLRIYMYKDGLARFA 642

  Fly   753 SVKYSAKTDTLNDRCMHLTNYSINKFSSNYSKNEDVNACHGHKWTIKSLWTYLANRGVRTDCLWE 817
            |||||::...|::||||||||||||||.||:||||.|||.|||||::|||:.|.||||.|..||.
  Fly   643 SVKYSSELSNLDERCMHLTNYSINKFSQNYAKNEDFNACQGHKWTLQSLWSCLENRGVNTKRLWA 707

  Fly   818 ALRSLVLRTILAGENGINSMIRANVESKYSCFELFGFDVILDSDLVPWLLEVNISPSLHSELPLD 882
            .||:||::.|::||:|:|.|.|.||..:|:|||||||||:||.:|||||||:|||||||||||||
  Fly   708 TLRNLVIKGIVSGESGLNRMYRQNVNFRYNCFELFGFDVLLDENLVPWLLEINISPSLHSELPLD 772

  Fly   883 AHVKAPLVQGVLNTALYNVPPKLSLDKQKELAAEFSFPPGTQMCYDKRLYINYLSREEKIKHNTF 947
            .|||.||:|.|||||||.|||||:..:|.::..|.:..  ..:|:|||::...|:.||..|||.:
  Fly   773 LHVKGPLIQAVLNTALYQVPPKLNERQQADILEELNLT--GPLCHDKRIFTTCLTAEEVRKHNQY 835

  Fly   948 TRKSMEDRNEYVDAILNNLTPDDVRCLIIAEDELARCAPLERIFPTDQTHKYLKYNDTPRYYNRL 1012
            |.:|:|.|.||||.||:||.||||||||:||||||||.||||||||..||.||:|.:..||||||
  Fly   836 TNRSIEFREEYVDTILDNLLPDDVRCLIVAEDELARCQPLERIFPTAGTHVYLRYVENARYYNRL 900

  Fly  1013 LDAWESRYANNRTEGIALLRDYCQNKYHLQVPTPPAKKDSNDEETTPATPNTVKEEIE 1070
            |||||::||.||..|||||..||::||||||.....:|:          ||....||:
  Fly   901 LDAWETKYAKNREMGIALLSRYCRDKYHLQVSDAAMEKE----------PNVALTEID 948

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TTLL4A	NP_001162947.1	TTL	614..908	CDD:281171	200/293 (68%)
TTLL4B	NP_001260010.1	TTL	504..799	CDD:281171	200/294 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45448394
Domainoid	1	1.000	351	1.000	Domainoid score	I975
eggNOG	1	0.900	-	-		E1_KOG2156
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	515	1.000	Inparanoid score	I1257
Isobase	1	0.950	-	0	Normalized mean entropy	S5103
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250453at33208
OrthoFinder	1	1.000	-	-		FOG0006381
OrthoInspector	1	1.000	-	-		otm26240
orthoMCL	1	0.900	-	-		OOG6_101354
Panther	1	1.100	-	-	P	PTHR12241
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4643
	12	11.750