DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TTLL4A and Ttll5

DIOPT Version :9

Sequence 1:	NP_001162947.1	Gene:	TTLL4A / 47729	FlyBaseID:	FBgn0026147	Length:	1071	Species:	Drosophila melanogaster
Sequence 2:	XP_006516052.1	Gene:	Ttll5 / 320244	MGIID:	2443657	Length:	1337	Species:	Mus musculus

Alignment Length:	525	Identity:	160/525 - (30%)
Similarity:	260/525 - (49%)	Gaps:	66/525 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   520 SSQSSEDDLKNPDS----------LLVPSLFPYVPPYLSFSSNTKRGPRVPPDLHRVLKWRITNI 574
            :|.|.::||.|.:.          ..:|.|..:....|:..:|.    ||..:.:. |.::|...
Mouse    13 ASSSEDEDLANQEDHPCIMWTGGCRRIPVLVFHAEAILTKDNNI----RVIGERYH-LSYKIVRT 72

  Fly   575 MPKVVRLILANSGMRML-KKTNDWMGVW-GKHLKSPCFKAIRSYQKINHLPGSFRIGRKDSCWKN 637
            ..::||.||...|...: ..:.|:..:| |.|||....:.:...||:||.|.|:.:.|||..:||
Mouse    73 DSRLVRSILTAHGFHEVHPSSTDYNLMWTGSHLKPFLLRTLSEAQKVNHFPRSYELTRKDRLYKN 137

  Fly   638 LQRQMGKHSNKEFGFMPRTYIIPNDLGALRRHWPKYAQRNTKWIIKPPASARGAGIRVINRWGQI 702
            :.|....|..|.|..:|:|:::|.:......   .|::....||:||.||:||.|:.:||...||
Mouse   138 IIRMQHTHGFKAFHILPQTFLLPAEYAEFCN---SYSKDRGPWIVKPVASSRGRGVYLINNPNQI 199

  Fly   703 PKRRPLIVQKYIERPLLINGSKFDLRLYVLVTSVNPLRVFMYHNGLARFASVKYSAKTDTLNDRC 767
            .....::|.:||..||||:..|||:||||||||.:||.:::|..||||||:|:|...:..:.::.
Mouse   200 SLEENILVSRYINNPLLIDDFKFDVRLYVLVTSYDPLVIYLYEEGLARFATVRYDQGSKNIRNQF 264

  Fly   768 MHLTNYSINKFSSNYSKNEDVNA-CHGHKWTIKSLWTYLANRGVRTDCLWEALRSLVLRTILAGE 831
            |||||||:||.|.:|...:|... .:|:||::.::..||...|..|..|...:..|:::||::.|
Mouse   265 MHLTNYSVNKKSGDYVSCDDPEVEDYGNKWSMSAMLRYLKQEGKDTTALMAHVEDLIIKTIISAE 329

  Fly   832 NGINSMIRANVESKYSCFELFGFDVILDSDLVPWLLEVNISPSLHSELPLDAHVKAPLVQGVLNT 896
            ..|.:..:..|..:.|||||:||||::|:.|.|||||||:||||..:.|||..:||.::..:..
Mouse   330 LAIATACKTFVPHRSSCFELYGFDVLIDNTLKPWLLEVNLSPSLACDAPLDLKIKASMISDMFT- 393

  Fly   897 ALYNVPPKLSLDKQKELAAEFSFPPGTQMCYDKRLYINYLSREEKIKHNTFTRKSMEDRNEYVDA 961
                             ...|......|...::.:|.::    |..:.|.|.:..........||
Mouse   394 -----------------VVGFVCQDPAQRTSNRSIYPSF----ESSRRNPFQKPQRTRPLSASDA 437

  Fly   962 ILNN-------------------LTPDDVRCLIIAEDELARCAPLERIFPTDQTHK----YLKYN 1003
            .:.|                   |:.::::.|...::|..|.....|||||.:|.:    ||::.
Mouse   438 EMKNLVASAREKVPGKLGGSVLGLSMEEIKVLRRVKEENDRRGGFIRIFPTSETWEIYGSYLEHK 502

  Fly  1004 DTPRY 1008
            .:..|
Mouse   503 TSMNY 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TTLL4A	NP_001162947.1	TTL	614..908	CDD:281171	114/294 (39%)
Ttll5	XP_006516052.1	TTL	117..395	CDD:397308	114/298 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2156
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250453at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101354
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.720