DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TTLL4A and Ttll6

DIOPT Version :9

Sequence 1:	NP_001162947.1	Gene:	TTLL4A / 47729	FlyBaseID:	FBgn0026147	Length:	1071	Species:	Drosophila melanogaster
Sequence 2:	XP_038943644.1	Gene:	Ttll6 / 287646	RGDID:	1311922	Length:	667	Species:	Rattus norvegicus

Alignment Length:	568	Identity:	174/568 - (30%)
Similarity:	270/568 - (47%)	Gaps:	87/568 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   522 QSSEDDLKNPDSLLVPSLFPYVPPYLSF-SSNTKR--------GPRVPPDLHRVLKWRITNIMPK 577
            :||.:||:....|:.          |:| ..||::        |.:.......|:  .::|....
  Rat    18 ESSTEDLEELKKLVA----------LAFVRENTQKRLQNAQQHGKKKRKKKRLVI--NLSNCRYD 70

  Fly   578 VVRLILANSGMRMLKKTNDWMGVWGKHLKS-PCFKAIRSYQKINHLPGSFRIGRKDSCWKNLQRQ 641
            .||......|:|.....:||...|..:..| .....::|||||||.||...|.|||...:|:.|.
  Rat    71 SVRRAAQQYGLREAGDNDDWTLYWTDYSVSLERVMEMKSYQKINHFPGMSEICRKDLLARNMSRM 135

  Fly   642 MGKHSNKEFGFMPRTYIIPNDLGALRRHWPKYAQRNTKWIIKPPASARGAGIRVINRWGQIPKRR 706
            : |...|:|.|.|||:.:|.|.|.|:.:  ...::|..:|.||.:..:|.||.:.....:|....
  Rat   136 L-KLFPKDFHFFPRTWCLPADWGDLQTY--SRTRKNKTYICKPDSGCQGRGIFITRSVKEIKPGE 197

  Fly   707 PLIVQKYIERPLLINGSKFDLRLYVLVTSVNPLRVFMYHNGLARFASVKYS-AKTDTLNDRCMHL 770
            .:|.|.||.:|.:|:|.|||||:||||||.:|||||:|:.||||||:..|| ..|:.|::.||||
  Rat   198 DMICQLYISKPFIIDGFKFDLRVYVLVTSCDPLRVFVYNEGLARFATTSYSHPNTENLDEICMHL 262

  Fly   771 TNYSINKFSSNYSKNEDVNACHGHKWTIKSLWTYLANRGVRTDCLWEALRSLVLRTILAGENGIN 835
            |||||||.|||:.:    :|..|.|..:.:..:|:...|...:.:|.|:..::::|:::.    :
  Rat   263 TNYSINKHSSNFIQ----DAHSGSKRKLSTFNSYMKTHGYDVEQIWRAIEDVIIKTLISA----H 319

  Fly   836 SMIRANVESKY-------SCFELFGFDVILDSDLVPWLLEVNISPSLHSELPLDAHVKAPLVQGV 893
            .:|:.|..:.:       :|||:.|||::||..|.|||||||.|||..::..||..||..|:...
  Rat   320 PVIKHNYHTCFPSHTLNSACFEILGFDILLDRKLKPWLLEVNHSPSFSTDSKLDKEVKDSLLYDA 384

  Fly   894 LNTALYNVPPKLSLDKQKELAAEFSFPPGTQMCYDKRLYINYLSREEKIKHNTFTRKSMEDRNEY 958
            |  .|.|:.   |.||:|.|..|.......|.|.::.:      |.|::|  .|....::...||
  Rat   385 L--VLVNLG---SCDKKKVLEEERQRGRFLQQCPNREI------RMEEVK--GFQAVRLQKTEEY 436

  Fly   959 VDAILNNLTPDDVRCLIIAEDELARCAPLERIFPTDQTHKYLKY--NDTPRYYNRLLDAWESRYA 1021
                                 |...|.....|:|.....||.|:  :::..:.|.:.......||
  Rat   437 ---------------------EKKNCGGFRLIYPGQNLEKYEKFFQDNSSLFQNTVASRARELYA 480

  Fly  1022 NNRTEGIALLRDYCQNKYHLQVPTPPAKKDSNDEETTPATPNTVKEEI 1069
            .   :.|..||...|||:.|       ||:..:|....:.....:::|
  Rat   481 R---QLIQELRQKQQNKFFL-------KKERKEEMQGESAGEQARDKI 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TTLL4A	NP_001162947.1	TTL	614..908	CDD:281171	120/301 (40%)
Ttll6	XP_038943644.1	TTL	105..395	CDD:397308	120/305 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250453at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920