Protein Alignment TTLL4A and TTLL3

DIOPT Version :10

• Sequence 1: NP_723642.2
• Gene: TTLL4A / 47729
• FlyBaseID: FBgn0026147
• Length: 1071
• Species: Drosophila melanogaster
• Sequence 2: NP_001021100.3
• Gene: TTLL3 / 26140
• HGNCID: 24483
• Length: 915
• Species: Homo sapiens
• Alignment Length: 552
• Identity: 135/552 - (24%)
• Similarity: 200/552 - (36%)
• Gaps: 174/552 - (31%)

  Fly   446 LEPEHKQEDHRSAIDFDRNDDFDED-------------------DDLD-----------NLSN-- 478
            |.|..|..|..:..|.|..:|.|||                   ||||           ||.|
Human   195 LLPPQKDLDSSAMGDSDTTEDEDEDEDEEFQPSQLFDFDDLLKFDDLDGTHALMVGLCLNLRNLP 259

  Fly   479 -FDESDTASVLS-----DTEDGYRA-----------HAFKLT----------HSVDRFSSPQSTP 516
             |||.|..|...     ..||..:|           :..||.          .:|:..:|....|
Human   260 WFDEVDANSFFPRCYCLGAEDDKKAFIEDFWLTAARNVLKLVVKSEWKSYPIQAVEEEASGDKQP 324

  Fly   517 SFLSSQSSEDDLKNPDSLLVPSLFPYVPPYLSFSSNTKRGPRVPPDLHRVLKWRITNIMPKVVRL 581
               ..|.....|.:|:  .|.........|||..::.        |:.:.|:          ..|
Human   325 ---KKQEKNPVLVSPE--FVDEALCACEEYLSNLAHM--------DIDKDLE----------APL 366

  Fly   582 ILANSGMRMLKKTNDWMGVWGKHLKSPCFKAIRSYQKINHLPGSFRIGRKDSCWKNLQRQMGKHS 646
            .|...|             |...|:. .::.:....::.||  ..::.|.:...:.||.
Human   367 YLTPEG-------------WSLFLQR-YYQVVHEGAELRHL--DTQVQRCEDILQQLQA------ 409

  Fly   647 NKEFGFMPRTYIIPN-DLGALRRHWPKYAQRNTKWIIKPPASARGAGI----------RVINRWG 700
                       ::|. |:         ...||. ||:||.|.:||.||          :::|...
Human   410 -----------VVPQIDM---------EGDRNI-WIVKPGAKSRGRGIMCMDHLEEMLKLVNGNP 453

  Fly   701 QIPKRRPLIVQKYIERPLLINGSKFDLRLYVLVTSVNPLRVFMYHNGLARFASVKYSAKTDTLND 765
            .:.|....:|||||||||||.|:|||||.:.|||..|||.|:.|.:...||::..:|.|.   .|
Human   454 VVMKDGKWVVQKYIERPLLIFGTKFDLRQWFLVTDWNPLTVWFYRDSYIRFSTQPFSLKN---LD 515

  Fly   766 RCMHLTNYSINKFSSNYSKNEDVNACHGH-------KWTIKSLWTYLANRGVRTDCLWE-----A 818
            ..:||.|.||.|...        |:||.|       .|:.:....:|...|...  .|.     .
Human   516 NSVHLCNNSIQKHLE--------NSCHRHPLLPPDNMWSSQRFQAHLQEMGAPN--AWSTIIVPG 570

  Fly   819 LRSLVLRTILAGENGINSMIRANVESKYSCFELFGFDVILDSDLVPWLLEVNISPSLHSELPLDA 883
            ::..|:..:...::        .|:.:.:.|||:|.|.:...|..|||:|:|.||::   .|..|
Human   571 MKDAVIHALQTSQD--------TVQCRKASFELYGADFVFGEDFQPWLIEINASPTM---APSTA 624

  Fly   884 HVKAPLVQGVLNTALYNVPPKLSLDKQKELAA 915
             |.|.|..||....|..|..:: ||:..:..|
Human   625 -VTARLCAGVQADTLRVVIDRM-LDRNCDTGA 654

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TTLL4A	NP_723642.2	TTL	614..909	CDD:397308	89/317 (28%)
TTLL3	NP_001021100.3	TTL	356..648	CDD:397308	96/378 (25%)