Protein Alignment TTLL4A and TTLL8

DIOPT Version :10

• Sequence 1: NP_723642.2
• Gene: TTLL4A / 47729
• FlyBaseID: FBgn0026147
• Length: 1071
• Species: Drosophila melanogaster
• Sequence 2: XP_024307940.1
• Gene: TTLL8 / 164714
• HGNCID: 34000
• Length: 776
• Species: Homo sapiens
• Alignment Length: 739
• Identity: 155/739 - (20%)
• Similarity: 271/739 - (36%)
• Gaps: 203/739 - (27%)

  Fly   248 QKAGASRRDSREVDGTVIIGRRDN------SEDRTWQGQKYEKHVLKEKLPSNDLKADYLDNGWG 306
            ::.|.|...|.:.|     ||.:|      |:|.. ...:.:::.:..:|....:|...:.:.:|
Human     4 ERKGLSLASSSDGD-----GREENKLKQGISQDLA-SSSRLDRYKIARQLTEKAIKEKKIFSIYG 62

  Fly   307 GDPGSEDDYR-----DIKDSYDPVVVIDNGLEQVGVHRRYC-RMTENTVLDGSGDTLINNNNNEL 365
            ..|......|     :.|..:.|.|:.|...|...|:...| ::.||.      :..:...:|..
Human    63 HYPVVRAALRRKGWVEKKFHFLPKVIPDVEDEGARVNDDTCAKVKENQ------EMALEKTDNIH 121

  Fly   366 KIMRKSTDQPMPRLPMTPKRAKGGTVSTKKPMPTVHRVLLYSTQSPRLGRKQQFSTQRLSVKQQS 430
            .:|.:.....||.|..|.||          .:...|. |.|........:...|:|:
Human   122 DVMSRLVKNEMPYLLWTIKR----------DIIDYHS-LTYDQMLNHYAKTASFTTK-------- 167

  Fly   431 SKVLGAGDERQTVLLLEPEHKQEDHRSAIDFDRNDDF--------DEDDDLDNLSNFDESDTASV 487
               :|.....:::....|.:.             |.|        .|.:..:.|.:|..:..:|:
Human   168 ---IGLCVNMRSLPWYVPANP-------------DSFFPRCYSLCTESEQQEFLEDFRRTMASSI 216

  Fly   488 LSDTEDGYRAHAFKLTH-SVDRFSSPQSTP------SFLSSQSSEDDLKNPDSLLVPSLFPYVPP 545
            |.          :.::| |..|  |.:|.|      :..|..||..|.:|.::.|
Human   217 LK----------WVVSHQSCSR--SSRSKPRDQREEAGSSDLSSRQDAENAEAKL---------- 259

  Fly   546 YLSFSSNTKRGPRVPPDLHRVLKWRITNIMPKVVRLILANSGMRMLKKTND---------WMGVW 601
                               |.|..::.:|..||.:..|.......:..:.|         |..:
Human   260 -------------------RGLPGQLVDIACKVCQAYLGQLEHEDIDTSADAVEDLTEAEWEDL- 304

  Fly   602 GKHLKSPCFKAIRSYQKINHLPGSFRIGRKDSCWKNLQRQMGKHSNKEFGFMPRTYIIPNDLGAL 666
                       .:.|..:.|  |...|....:.:...|..:    |:.....|:|     |:..|
Human   305 -----------TQQYYSLVH--GDAFISNSRNYFSQCQALL----NRITSVNPQT-----DIDGL 347

  Fly   667 RRHWPKYAQRNTKWIIKPPASARGAGIRVINRWGQI----PKRRPL------IVQKYIERPLLIN 721
            |          ..|||||.|.:||..|..::|..:|    ....||      :||||||.||||.
Human   348 R----------NIWIIKPAAKSRGRDIVCMDRVEEILELAAADHPLSRDNKWVVQKYIETPLLIC 402

  Fly   722 GSKFDLRLYVLVTSVNPLRVFMYHNGLARFASVKYSAKTDTLNDRCMHLTNYSINKFSSNYSKNE 786
            .:|||:|.:.|||..|||.::.|.....||::.::|  .|.| |..:||.|.::.|:..|.....
Human   403 DTKFDIRQWFLVTDWNPLTIWFYKESYLRFSTQRFS--LDKL-DSAIHLCNNAVQKYLKNDVGRS 464

  Fly   787 DVNACHGHKWTIKSLWTYLANRG---VRTDCLWEALRSLVLRTILAGENGINSMIRANVESKYSC 848
            .:...| :.||......||..:|   |....::.:::..:...:...::        :||.:.:.
Human   465 PLLPAH-NMWTSTRFQEYLQRQGRGAVWGSVIYPSMKKAIAHAMKVAQD--------HVEPRKNS 520

  Fly   849 FELFGFDVILDSDLVPWLLEVNISPSLHSELPLDAHVKAPLVQGVLNTALYNVPPKLSLDKQKEL 913
            |||:|.|.:|..|..|||:|:|.||::|...|:.|.:.|.:.:..:         |:::|:..::
Human   521 FELYGADFVLGRDFRPWLIEINSSPTMHPSTPVTAQLCAQVQEDTI---------KVAVDRSCDI 576

  Fly   914 AAEFSF---------PP--GTQMC 926
             ..|..         ||  |:.:|
Human   577 -GNFELLWRQPVVEPPPFSGSDLC 599

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TTLL4A	NP_723642.2	TTL	614..909	CDD:397308	84/307 (27%)
TTLL8	XP_024307940.1	TTL	<348..574	CDD:397308	75/256 (29%)