DRSC/TRiP Functional Genomics Resources

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Protein Alignment TTLL4A and TTL

DIOPT Version :10

Sequence 1:NP_723642.2 Gene:TTLL4A / 47729 FlyBaseID:FBgn0026147 Length:1071 Species:Drosophila melanogaster
Sequence 2:NP_714923.1 Gene:TTL / 150465 HGNCID:21586 Length:377 Species:Homo sapiens


Alignment Length:397 Identity:103/397 - (25%)
Similarity:176/397 - (44%) Gaps:84/397 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   572 TNIMPKVVRLILANSGMRMLKKTNDWMGVW-GKHLKSPCFKAIRSYQKINHLPGSFRI-----GR 630
            :::..:|.||:||....:.|::.|....:. |:..:.|       :.::.|.||..::     |.
Human    11 SSVYAEVSRLLLATGHWKRLRRDNPRFNLMLGERNRLP-------FGRLGHEPGLVQLVNYYRGA 68

  Fly   631 KDSCWKNLQRQMGKHS---NKEFGFMPRTYII-PNDL-----GALRRHWPKYAQRNTK------- 679
            ...|.|....::.|.|   .:...:.|.:|:| |.:|     .|.....|..:...|.       
Human    69 DKLCRKASLVKLIKTSPELAESCTWFPESYVIYPTNLKTPVAPAQNGIQPPISNSRTDEREFFLA 133

  Fly   680 -------------WIIKPPASARGAGIRV----------INRWGQIPKRRPLIVQKYIERPLLIN 721
                         ||.|..|.|:|.||.:          |:..||:.     ::|||:|.|||:.
Human   134 SYNRKKEDGEGNVWIAKSSAGAKGEGILISSEASELLDFIDNQGQVH-----VIQKYLEHPLLLE 193

  Fly   722 GS--KFDLRLYVLVTSVNPLRVFMYHNGLARFASVKYSAKTDTLNDRCMHLTNYSINK-FSSNYS 783
            ..  |||:|.:|||.  :...:::|..|:.|.||..|  ..|...|:..||||:.|.| :|.||.
Human   194 PGHRKFDIRSWVLVD--HQYNIYLYREGVLRTASEPY--HVDNFQDKTCHLTNHCIQKEYSKNYG 254

  Fly   784 KNEDVNACHGHKWTIKSLWTYLA---NRGVRTDCLWEALRSLVLRTILAGENGINSMIRANVESK 845
            |.|:     |::...|....||.   |..:.:..|.: ::.::...:|:.|..|::.     ...
Human   255 KYEE-----GNEMFFKEFNQYLTSALNITLESSILLQ-IKHIIRNCLLSVEPAISTK-----HLP 308

  Fly   846 YSCFELFGFDVILDSDLVPWLLEVNISPSLHSELPLDAHVKAPLVQGVLNTALYNVPPKLSLDKQ 910
            |..|:|||||.::|.:|..||:|||.:|:...:|      .|.|.||:::.|:.:|.|...:::.
Human   309 YQSFQLFGFDFMVDEELKVWLIEVNGAPACAQKL------YAELCQGIVDIAISSVFPPPDVEQP 367

  Fly   911 KELAAEF 917
            :...|.|
Human   368 QTQPAAF 374

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TTLL4ANP_723642.2 TTL 614..909 CDD:397308 92/344 (27%)
TTLNP_714923.1 TTL 81..367 CDD:397308 86/311 (28%)

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