DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TTLL4A and ttll5

DIOPT Version :9

Sequence 1:	NP_001162947.1	Gene:	TTLL4A / 47729	FlyBaseID:	FBgn0026147	Length:	1071	Species:	Drosophila melanogaster
Sequence 2:	XP_017207366.2	Gene:	ttll5 / 100006339	ZFINID:	ZDB-GENE-100922-236	Length:	1190	Species:	Danio rerio

Alignment Length:	545	Identity:	177/545 - (32%)
Similarity:	286/545 - (52%)	Gaps:	64/545 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   520 SSQSSEDDLKNPDSLLVPSLFPYVPPYLSFSSNTKRGP--------RVPPD--LHRV-----LKW 569
            |..||||:|:.             .|.:::|..:||.|        .|..|  :..|     |.:
Zfish    11 SKSSSEDELEK-------------QPCIAWSGVSKRIPVLLFCAEAIVSKDVAIRSVGEKYNLAF 62

  Fly   570 RITNIMPKVVRLILANSGMRML-KKTNDWMGVW-GKHLKSPCFKAIRSYQKINHLPGSFRIGRKD 632
            :|.....::||.||.|.|...: ..:||:..:| |.|||....::::.:||:||.|.|:.:.|||
Zfish    63 KIVRTESRLVRGILVNHGFHEVHPNSNDFNLMWTGSHLKPYLLRSLQDFQKVNHFPRSYELTRKD 127

  Fly   633 SCWKNLQRQMGKHSNKEFGFMPRTYIIPNDLGALRRHWPKYAQRNTKWIIKPPASARGAGIRVIN 697
            ..:||:||....|....|..:|:|:::|.:......   .:::....|||||.||:||.||.:::
Zfish   128 RLYKNIQRMQQSHGFHNFSIVPQTFVLPAEYQEFSN---SFSKDKGPWIIKPVASSRGRGIYLVS 189

  Fly   698 RWGQIPKRRPLIVQKYIERPLLINGSKFDLRLYVLVTSVNPLRVFMYHNGLARFASVKYSAKTDT 762
            ...|||....::|.:||..||||:..|||:||||||||.:||.:::|..||||||:|||...|..
Zfish   190 NISQIPLDENILVSRYISNPLLIDDFKFDVRLYVLVTSYDPLVIYLYEEGLARFATVKYDHATAN 254

  Fly   763 LNDRCMHLTNYSINKFSSNYSKNEDVNA-CHGHKWTIKSLWTYLANRGVRTDCLWEALRSLVLRT 826
            :.::.|||||||:||.||:|...:|... .:|:||::.::..||...|..|..|...:..|:::.
Zfish   255 IKNQFMHLTNYSVNKKSSDYVSCDDPEVEDYGNKWSMSAMLRYLRQEGKDTTLLMGQIEDLIIKA 319

  Fly   827 ILAGENGINSMIRANVESKYSCFELFGFDVILDSDLVPWLLEVNISPSLHSELPLDAHVKAPLVQ 891
            :|:.|..|.:..:..|..:.:||||:||||::||:|.|||||||:||||..:.|||..|||.::.
Zfish   320 VLSAEIHIATSCKMFVPHRCNCFELYGFDVLIDSNLKPWLLEVNLSPSLACDAPLDLKVKASMIS 384

  Fly   892 GVLNTALYNVPPKLSLDKQKELAAEFSFPPGTQMCYDKRLYI--NYLSREEKIKHNTFTRKSMED 954
            .:.:...:.....|....:.|.|.           :|.||.|  ....|:.....::...::..:
Zfish   385 DMFSLVGFVCQDPLLRQPRAERAG-----------FDLRLKIPTQKHQRQRPASSSSADPQTQRE 438

  Fly   955 RN--EYVDAILNNLTPDDVRCLIIAEDELARCAPLERIFPTDQTHK----YLKYNDT-------P 1006
            ::  ::.|..| :|:.::::.|...::|..|.....|||||..|.:    ||:|..:       .
Zfish   439 KHGCKHTDDTL-SLSAEEMKVLRRVQEEYERRGGFIRIFPTPDTWEIYSGYLEYKTSLNAMLANK 502

  Fly  1007 RYYNRLLDAWESRYANNRTEGIALL 1031
            .::.|.|   .||.....|:||:|:
Zfish   503 LFHRRSL---TSRSRVQATDGISLV 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TTLL4A	NP_001162947.1	TTL	614..908	CDD:281171	118/294 (40%)
ttll5	XP_017207366.2	TTL	111..387	CDD:281171	117/278 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250453at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101354
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820