Protein Alignment NFATC1 and nfatc1

DIOPT Version :10

• Sequence 1: NP_001265598.1
• Gene: NFATC1 / 4772
• HGNCID: 7775
• Length: 943
• Species: Homo sapiens
• Sequence 2: XP_012820381.1
• Gene: nfatc1 / 780197
• XenbaseID: XB-GENE-876756
• Length: 945
• Species: Xenopus tropicalis
• Alignment Length: 950
• Identity: 680/950 - (71%)
• Similarity: 779/950 - (82%)
• Gaps: 12/950 - (1%)

Human     1 MPSTSF--PVPSKFPLGP--AAAVFGRGETLGPAPRAGGTMKSAEEEHYGYASSNVSPALPLPTA 61
            ||.||.  .|||..||||  .|.|   .:|:...|.....||||||||:.|||||:|.:|.|...
 Frog     1 MPRTSVAAAVPSSLPLGPLYPACV---TDTVDFQPFFPFIMKSAEEEHFNYASSNLSASLSLGVT 62

Human    62 HSTLPAPCHNLQTSTP--GIIPPADHPSGYGAALDGGPAGYFLSSGHTRPDGAPALESPRIEITS 124
            :|:|..|||.||:|.|  .|||.:.||.|||..||....||:||.. .||.|.||||||||||||
 Frog    63 NSSLSNPCHGLQSSNPVISIIPSSSHPPGYGGNLDSEATGYYLSPS-IRPVGPPALESPRIEITS 126

Human   125 CLGLYHNNNQFFHDVEVEDVLPSSKRSPSTATLSLPSLEAYRDPSCLSPASSLSSRSCNSEASSY 189
            ||.::.|:||||::.::|:.:|.:||..|||||:||:::.||||||||||||||||||||||||:
 Frog   127 CLAMHPNHNQFFNEPDIEEAIPQAKRIHSTATLNLPNVDTYRDPSCLSPASSLSSRSCNSEASSF 191

Human   190 ESNYSYPYASPQTSPWQSPCVSPKTTDPEEGFPRGLGACTLLGSPRHSPSTSPRASVTEESWLGA 254
            |||||||:.||||||||||||||||||||||:.|.:..||||.|||||||||||.|::||:||.|
 Frog   192 ESNYSYPFTSPQTSPWQSPCVSPKTTDPEEGYQRSMVTCTLLSSPRHSPSTSPRTSISEENWLNA 256

Human   255 RSSRPASPCNKRKYSLNGRQPPYSPHHSPTPSPHGSPRVSVTDDSWLGNTTQYTSSAIVAAINAL 319
            .||||:|||.||||||||||..||||||||||||.||||||||::|||||.||||||||||||||
 Frog   257 PSSRPSSPCIKRKYSLNGRQTSYSPHHSPTPSPHNSPRVSVTDETWLGNTHQYTSSAIVAAINAL 321

Human   320 TTDSSLDLGDGVPVKSRKTTLEQPPSVALKVEPVGEDLGSPPPPADFAPEDYSSFQHIRKGGFCD 384
            |||.: |:.||:|:|||||..:..|:::||.|||.:|..:.....|.:|:|||.|.|||||.|||
 Frog   322 TTDPT-DMNDGIPIKSRKTAADHTPNMSLKTEPVCDDHSTMSSTNDLSPDDYSGFHHIRKGNFCD 385

Human   385 QYLAVPQHPYQWAKPKPLSPTSYMSPTLPALDWQLPSHSGPYELRIEVQPKSHHRAHYETEGSRG 449
            |||:|||..|||||||.:|||||:||:||||||.|||.|||||||||||||||||||||||||||
 Frog   386 QYLSVPQQSYQWAKPKNISPTSYLSPSLPALDWHLPSQSGPYELRIEVQPKSHHRAHYETEGSRG 450

Human   450 AVKASAGGHPIVQLHGYLENEPLMLQLFIGTADDRLLRPHAFYQVHRITGKTVSTTSHEAILSNT 514
            |||||.|||||||||||||||||.:||||||||||||||||||||||||||||||||||.|:|||
 Frog   451 AVKASTGGHPIVQLHGYLENEPLTIQLFIGTADDRLLRPHAFYQVHRITGKTVSTTSHETIISNT 515

Human   515 KVLEIPLLPENSMRAVIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHVPQPSGRTLSLQ 579
            |||||||||||:|||:|||||||||||||||||||||||||||||||||||||:||.:||||:||
 Frog   516 KVLEIPLLPENNMRAIIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHIPQANGRTLTLQ 580

Human   580 VASNPIECSQRSAQELPLVEKQSTDSYPVVGGKKMVLSGHNFLQDSKVIFVEKAPDGHHVWEMEA 644
            |||||||||||||||||||||||||::||:|||||:|:||||..|||||||||||||||||||||
 Frog   581 VASNPIECSQRSAQELPLVEKQSTDNFPVIGGKKMILNGHNFHPDSKVIFVEKAPDGHHVWEMEA 645

Human   645 KTDRDLCKPNSLVVEIPPFRNQRITSPVHVSFYVCNGKRKRSQYQRFTYLPANVPIIKTEPTDDY 709
            |||:::.|||:|||||||||||||:|||.|:||||||||||||||.|||||||||||||||||||
 Frog   646 KTDKEMFKPNTLVVEIPPFRNQRISSPVQVNFYVCNGKRKRSQYQIFTYLPANVPIIKTEPTDDY 710

Human   710 EPAPTCGPVSQGLSPLPRPYYSQQLAMPPDPSSCLVAGFPPCPQRSTLMPAAPGVSPKLHDLSPA 774
            |.|.||.|:||||:.|.:||||||:.|||||.||||:||..|.||:|:|.::|..||||||||.:
 Frog   711 ESAQTCVPMSQGLTQLSKPYYSQQIMMPPDPGSCLVSGFTSCQQRNTVMSSSPISSPKLHDLSAS 775

Human   775 AYTKGVASPGHCHLGLPQPAGEAPAVQDVPRPVATHPGSPGQPPPALLPQQVSAPPSSSCPPGLE 839
            ||.|.:::|||..|||.|..|..|.:|:|||.:..||.||.|..|.:|..|||...|||||.|.:
 Frog   776 AYNKCISNPGHTQLGLQQTTGGVPTIQEVPRSIVGHPSSPDQSSPIMLQPQVSLHQSSSCPLGFQ 840

Human   840 HSLCPSSPSPPLPPATQEPTCLQPCSPACPPATGRPQHLPSTVRRDESPTAGPRLLPEVHEDGSP 904
            .::.|:|||.|:|..||||:.||||||......|:|||....|:|:|||.:.|..|||:|||.:.
 Frog   841 QTVYPNSPSSPVPSITQEPSYLQPCSPTHSAVIGQPQHQHQKVQRNESPNSQPLSLPELHEDSNH 905

Human   905 NLAPIPVTVKREPEELDQLYLDDVNEIIRNDLSS-TSTHS 943
            ||||||||:||||||||||||||||||||||||| .:.||
 Frog   906 NLAPIPVTIKREPEELDQLYLDDVNEIIRNDLSSNNNVHS 945

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NFATC1	NP_001265598.1	PHA03247	<7..446	CDD:223021	298/442 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	22..48		10/25 (40%)
		Calcineurin-binding	118..123		4/4 (100%)
		Transactivation domain A (TAD-A)	126..218		66/91 (73%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	200..298		79/97 (81%)
		3 X SP repeats	203..298		76/94 (81%)
		Nuclear localization signal	265..267		1/1 (100%)
		Nuclear export signal	310..321		10/10 (100%)
		RHD-n_NFAT	416..590	CDD:143641	160/173 (92%)
		IPT	595..695	CDD:472823	83/99 (84%)
		Nuclear localization signal	682..684		1/1 (100%)
		Transactivation domain B (TAD-B)	703..943		145/240 (60%)
		PHA03247	<712..890	CDD:223021	97/177 (55%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	787..912		64/124 (52%)
		Nuclear export signal	924..933		8/8 (100%)
nfatc1	XP_012820381.1	RHD-n_NFAT	417..591	CDD:143641	160/173 (92%)
		IPT	596..696	CDD:472823	83/99 (84%)