DRSC/TRiP Functional Genomics Resources

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Protein Alignment NFATC1 and NFAT

DIOPT Version :10

Sequence 1:NP_001265598.1 Gene:NFATC1 / 4772 HGNCID:7775 Length:943 Species:Homo sapiens
Sequence 2:NP_001096974.1 Gene:NFAT / 32321 FlyBaseID:FBgn0030505 Length:1457 Species:Drosophila melanogaster


Alignment Length:1014 Identity:233/1014 - (22%)
Similarity:352/1014 - (34%) Gaps:293/1014 - (28%)


- Green bases have known domain annotations that are detailed below.


Human    34 GG---TMKSAEEEHYGYASSNVSPALPLPTAHST---------------------LPAPCHNLQT 74
            ||   |...|.:.||   .||....:.:.| :||                     ||...|.:..
  Fly    64 GGNNNTNFQAYQHHY---KSNFGMRMTMST-NSTMSARIHRKGFRIPSKRQPGKGLPGKLHTITR 124

Human    75 STPGII------------PPADHPSGYGAALDGGPAGYFLSSGHTR---PDGAPALESPRIEITS 124
            :.||.:            ||.|:.:..|...|          .||.   ..||..:..|.....|
  Fly   125 TGPGKMVPGKRIPQRPHPPPCDNSNDSGLGFD----------QHTELRSSAGAGGVTDPAANGGS 179

Human   125 CLGLYHNNNQFFHDVEVEDVLPSSKRSPSTATLSLPSLEAYRDPSCLSPASSLSSRSCNSEASSY 189
                  .:|             |.:||......:|.:..|   .:..:.|::::|.:.......:
  Fly   180 ------GSN-------------SGQRSSLLVNSALTNTVA---AAAAAAAAAVASNTLQQHQQHH 222

Human   190 ESNYSYPYASPQTSPWQSPCVSPKTTDPEEGFPRGLGACTLLGSPRHSPSTSPRASVTEESWLGA 254
            :..........|....|......:...|::...|.:..      .|...:|...|...|:..|.:
  Fly   223 QQQQQQQQQQQQQQQQQQQQQQQQQHSPQQHLIRAIPV------SRSRNNTKVMAHCLEDLDLIS 281

Human   255 RSSRPASP-------------CNKRKYSLNGRQPPYSPHHSPTPSPHGSPRVSVTDDSWLGNTTQ 306
            .||..:|.             .|..|.:..|......|                     .|...|
  Fly   282 ASSEDSSTIATPAGLDEDTGFVNDTKTTTTGGNSSSDP---------------------FGGVFQ 325

Human   307 YTSSAIVAAINALTTDSSLDLGDGVPVKSRKTTLEQPPSVALKVEPVGEDLGSPPPPADFAPEDY 371
            .|.:|:.||:||........     .|:.::..|.|...:.|:.:...:...|.........:.:
  Fly   326 ATEAAVAAAVNAFNLQQQQH-----SVQQQQHQLFQYNGLLLQPQQQLQQQQSHHQQQQQQQQHH 385

Human   372 SSFQHI-RKGGFC-------------DQYL-----AVPQHPYQWAKPKP---------------L 402
            ...:|| ||...|             |:::     :|...|...|.|.|               |
  Fly   386 RHGKHIKRKKLECNQVELDNDDACSEDEFIRKIASSVTMSPTLEATPSPPPIVASVAPATTIVSL 450

Human   403 SP-----------------TSYMS------------PTLPALDWQLPSHSGPYELRIEVQPKSHH 438
            .|                 |.::|            ||.| |:....|:.|..:|.|..||:..|
  Fly   451 LPLISSGNSNNNNNNNNIETKFISARNVTRVANKRQPTTP-LNSVASSNDGQVQLEILSQPEQQH 514

Human   439 RAHYETEGSRGAVKASAG-GHPIVQLHGYLENEPLMLQLFIGTADDRLLRPHAFYQVHRITGKTV 502
            ||.|:|||||||||..:| |.|||:|.||  ::..:||:|||| |...:.||.|||..::.||. 
  Fly   515 RARYQTEGSRGAVKDRSGNGFPIVRLTGY--DKVAVLQVFIGT-DIGRVAPHMFYQACKVAGKN- 575

Human   503 STTSHEAILSNTKVLEIPLLPENSMRAVIDCAGILKLRNSDIELRKGETDIGRKN----TRVRLV 563
            ||..:|..:..|.|:||...||..|....||.||||.||.|:|.|..| .:.:||    ||.|:|
  Fly   576 STQCNEKKVDGTMVIEIDFKPETDMTITCDCVGILKERNVDVEHRFPE-HLAQKNKKKSTRCRMV 639

Human   564 FRVHVPQPSGRTLSLQVASNPIECSQRSAQELPLVEKQSTDSYPVVGGKKMVLSGHNFLQDSKVI 628
            ||..:.:..|.|.:|||.||||.|:|...  :|.:.|:|.:|.||.||.::.:.|.|||:|:.|:
  Fly   640 FRTQLTRDDGTTETLQVCSNPIICTQPPG--VPEICKKSLNSCPVDGGLELFIIGKNFLKDTHVV 702

Human   629 FVE--KAPDGHH-----------------VWEMEAKTDRDLCKPNSLVVEIPPFRNQRITSPVHV 674
            |.|  .:.:|..                 :||.....|::......|:..:||:.:|.|..||.|
  Fly   703 FQETYDSVNGDDPATEIAVRQQLIGGTAALWEQSVLPDKEYLHQTHLICTVPPYLHQNILKPVQV 767

Human   675 SFYVCNGKRKRSQYQRFTY--------LPANVPIIKTEPTDD------------------YEPAP 713
            ...:.: ..|:|:...|||        |.|...:..|....|                  :..|.
  Fly   768 QVSIVS-SGKKSEPHTFTYTAKGQYTTLAAASTLSNTIHAQDVSGFMDTTSASNASGSSGWSAAG 831

Human   714 TCG-------------PVSQGLSPLPRPYYSQQLAMPPDPSSCLVAGFPPCPQRSTLMPAAPGVS 765
            ..|             .:..|:.|            ||     :....|...:||:|    |.|:
  Fly   832 GSGNNTSTGDNVEAKHEIDSGMMP------------PP-----ITTQIPMGVRRSSL----PSVT 875

Human   766 PKLHDLSPAAYTKGVASPGHCHLGLPQPAGEAPAVQDVPRPVATHPGSPGQPPPALLPQQVSAPP 830
            |.:.|..........||.......|......:|         .|...:|..|..||...:.:..|
  Fly   876 PMITDQQLVHLNAVAASAEALKTELDDSNSHSP---------LTGESTPDSPNAALQYHRFARKP 931

Human   831 S--------SSCPPGLEHSLCPSSPSPPLPPATQEPTCL 861
            |        |:..||....:.|::.:........:||.:
  Fly   932 SLDTIMYDQSNSLPGFPTVVAPATAAAVAAAVDIDPTAV 970

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NFATC1NP_001265598.1 PHA03247 <7..446 CDD:223021 94/526 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 22..48 6/16 (38%)
Calcineurin-binding 118..123 1/4 (25%)
Transactivation domain A (TAD-A) 126..218 10/91 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 200..298 16/110 (15%)
3 X SP repeats 203..298 15/107 (14%)
Nuclear localization signal 265..267 0/1 (0%)
Nuclear export signal 310..321 5/10 (50%)
RHD-n_NFAT 416..590 CDD:143641 81/178 (46%)
IPT 595..695 CDD:472823 33/126 (26%)
Nuclear localization signal 682..684 0/1 (0%)
Transactivation domain B (TAD-B) 703..943 33/198 (17%)
PHA03247 <712..890 CDD:223021 31/171 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 787..912 15/83 (18%)
Nuclear export signal 924..933
NFATNP_001096974.1 RHD-n_TonEBP 502..665 CDD:143642 79/167 (47%)
IPT 669..787 CDD:472823 33/118 (28%)
Blue background indicates that the domain is not in the aligned region.

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