Protein Alignment NFATC1 and Nfatc1

DIOPT Version :10

• Sequence 1: NP_001265598.1
• Gene: NFATC1 / 4772
• HGNCID: 7775
• Length: 943
• Species: Homo sapiens
• Sequence 2: XP_036016919.1
• Gene: Nfatc1 / 18018
• MGIID: 102469
• Length: 947
• Species: Mus musculus
• Alignment Length: 918
• Identity: 760/918 - (82%)
• Similarity: 807/918 - (87%)
• Gaps: 12/918 - (1%)

Human    29 PAPRAGGTMKSAEEEHYGYASSNVSPALPLPTAHSTLPAPCHNLQTSTPGI--IPPADHPSGYGA 91
            |.|..|..:.:|  |||.|.|.:|:..||||||||.|||.||:||||||||  :|.|:||..||.
Mouse    39 PDPGRGKELYAA--EHYSYVSPSVTSTLPLPTAHSALPAACHDLQTSTPGISAVPSANHPPSYGG 101

Human    92 ALDGGPAGYFLSSGHTRPDGAPALESPRIEITSCLGLYHNNNQFFHDVEVEDVLPSSKRSPSTAT 156
            |:|.||:|||||||:|||:|||.||||||||||.|||:|.:.||||||||||||||.||||||||
Mouse   102 AVDSGPSGYFLSSGNTRPNGAPTLESPRIEITSYLGLHHGSGQFFHDVEVEDVLPSCKRSPSTAT 166

Human   157 LSLPSLEAYRDPSCLSPASSLSSRSCNSEASSYESNYSYPYASPQTSPWQSPCVSPKTTDPEEGF 221
            |.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   167 LHLPSLEAYRDPSCLSPASSLSSRSCNSEASSYESNYSYPYASPQTSPWQSPCVSPKTTDPEEGF 231

Human   222 PRGLGACTLLGSPRHSPSTSPRASVTEESWLGARSSRPASPCNKRKYSLNGRQPPYSPHHSPTPS 286
            ||.||||.||||||||||||||||:|||||||||.|||.|||||||||||||||..|||||||||
Mouse   232 PRSLGACHLLGSPRHSPSTSPRASITEESWLGARGSRPTSPCNKRKYSLNGRQPSCSPHHSPTPS 296

Human   287 PHGSPRVSVTDDSWLGNTTQYTSSAIVAAINALTTDSSLDLGDGVPVKSRKTTLEQPPSVALKVE 351
            ||||||||||:|:||||||||||||||||||||||||:||||||||:|||||.||..||||||||
Mouse   297 PHGSPRVSVTEDTWLGNTTQYTSSAIVAAINALTTDSTLDLGDGVPIKSRKTALEHAPSVALKVE 361

Human   352 PVGEDLGSPPPPADFAPEDYSSFQHIRKGGFCDQYLAVPQHPYQWAKPKPLSPTSYMSPTLPALD 416
            |.|||||:.||.:||.||:| :|||:|||.||:|||:|||..|||||||.|||||||||:|||||
Mouse   362 PAGEDLGTTPPTSDFPPEEY-TFQHLRKGAFCEQYLSVPQASYQWAKPKSLSPTSYMSPSLPALD 425

Human   417 WQLPSHSGPYELRIEVQPKSHHRAHYETEGSRGAVKASAGGHPIVQLHGYLENEPLMLQLFIGTA 481
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||||||||
Mouse   426 WQLPSHSGPYELRIEVQPKSHHRAHYETEGSRGAVKASAGGHPIVQLHGYLENEPLTLQLFIGTA 490

Human   482 DDRLLRPHAFYQVHRITGKTVSTTSHEAILSNTKVLEIPLLPENSMRAVIDCAGILKLRNSDIEL 546
            |||||||||||||||||||||||||||.||||||||||||||||:|||:||||||||||||||||
Mouse   491 DDRLLRPHAFYQVHRITGKTVSTTSHEIILSNTKVLEIPLLPENNMRAIIDCAGILKLRNSDIEL 555

Human   547 RKGETDIGRKNTRVRLVFRVHVPQPSGRTLSLQVASNPIECSQRSAQELPLVEKQSTDSYPVVGG 611
            |||||||||||||||||||||:|||:||||||||||||||||||||||||||||||||||||:||
Mouse   556 RKGETDIGRKNTRVRLVFRVHIPQPNGRTLSLQVASNPIECSQRSAQELPLVEKQSTDSYPVIGG 620

Human   612 KKMVLSGHNFLQDSKVIFVEKAPDGHHVWEMEAKTDRDLCKPNSLVVEIPPFRNQRITSPVHVSF 676
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|||
Mouse   621 KKMVLSGHNFLQDSKVIFVEKAPDGHHVWEMEAKTDRDLCKPNSLVVEIPPFRNQRITSPVQVSF 685

Human   677 YVCNGKRKRSQYQRFTYLPANVPIIKTEPTDDYEPAPTCGPVSQGLSPLPRPYYSQQLAMPPDPS 741
            ||||||||||||||||||||||||||||||||:|||.||||:|||:||||||||||||.|||||.
Mouse   686 YVCNGKRKRSQYQRFTYLPANVPIIKTEPTDDFEPALTCGPMSQGISPLPRPYYSQQLTMPPDPG 750

Human   742 SCLVAGFPPCPQRSTLMPAAPGVSPKLHDLSPAAYTKGVASPGHC-HLGLPQPAGEAPAVQDVPR 805
            |||||||.||.||:||||..|..||||||||..|||||:.:|||. ||||..||.|||.:|:|||
Mouse   751 SCLVAGFAPCSQRNTLMPTPPNASPKLHDLSSPAYTKGLTNPGHSGHLGLQPPASEAPTMQEVPR 815

Human   806 PVATHPGSPGQPPPALLPQQVSAPPSSSCPPGLEHSLCPSSPSPPLPPATQEPTCLQPCSPACPP 870
            |:|..|.||.|||.|.|..|||...:||||.|....|||:|||.|||.|.|||.|||  |.|.||
Mouse   816 PMAIQPNSPEQPPSARLQPQVSPHLNSSCPLGRRQVLCPNSPSSPLPSAAQEPACLQ--SSALPP 878

Human   871 ATGRPQHLPSTVRRDESPTAGPRLLPEVHEDGSPNLAPIPVTVKREPEELDQLYLDDVNEIIRND 935
            ..|..|..|..|:|:|||.    :||||.||...|||||||.:|:||||||||||||||||||||
Mouse   879 DMGHRQPQPQKVQRNESPA----VLPEVCEDSGHNLAPIPVVIKQEPEELDQLYLDDVNEIIRND 939

Human   936 LSSTSTHS 943
            ||||..||
Mouse   940 LSSTIPHS 947

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NFATC1	NP_001265598.1	PHA03247	<7..446	CDD:223021	346/418 (83%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	22..48		7/18 (39%)
		Calcineurin-binding	118..123		4/4 (100%)
		Transactivation domain A (TAD-A)	126..218		85/91 (93%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	200..298		90/97 (93%)
		3 X SP repeats	203..298		87/94 (93%)
		Nuclear localization signal	265..267		1/1 (100%)
		Nuclear export signal	310..321		10/10 (100%)
		RHD-n_NFAT	416..590	CDD:143641	167/173 (97%)
		IPT	595..695	CDD:472823	97/99 (98%)
		Nuclear localization signal	682..684		1/1 (100%)
		Transactivation domain B (TAD-B)	703..943		162/240 (68%)
		PHA03247	<712..890	CDD:223021	116/178 (65%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	787..912		71/124 (57%)
		Nuclear export signal	924..933		8/8 (100%)
Nfatc1	XP_036016919.1	RHD-n_NFAT	425..599	CDD:143641	167/173 (97%)
		IPT	604..704	CDD:472823	97/99 (98%)
		PHA03247	<704..897	CDD:223021	131/194 (68%)