Protein Alignment NFATC1 and Nfatc1

DIOPT Version :10

• Sequence 1: NP_001265598.1
• Gene: NFATC1 / 4772
• HGNCID: 7775
• Length: 943
• Species: Homo sapiens
• Sequence 2: NP_001402650.1
• Gene: Nfatc1 / 100361818
• RGDID: 2319357
• Length: 939
• Species: Rattus norvegicus
• Alignment Length: 946
• Identity: 792/946 - (83%)
• Similarity: 842/946 - (89%)
• Gaps: 10/946 - (1%)

Human     1 MPSTSFPVPSKFPLGPAAAVFGRGETLGPAPRAGGTMKSAEEEHYGYASSNVSPALPLPTAHSTL 65
            ||||||||||||||||.|||.|.||||.|||.||||||:||||||.|||.:|:..||||||||.|
  Rat     1 MPSTSFPVPSKFPLGPPAAVCGSGETLRPAPLAGGTMKAAEEEHYSYASPSVTSTLPLPTAHSAL 65

Human    66 PAPCHNLQTSTPGI--IPPADHPSGYGAALDGGPAGYFLSSGHTRPDGAPALESPRIEITSCLGL 128
            ||.||:||||||||  :|.|:||||||.|:|.||:|||||||:|||:|||.||||||||||.|||
  Rat    66 PAACHDLQTSTPGISAVPSANHPSGYGGAVDSGPSGYFLSSGNTRPNGAPTLESPRIEITSYLGL 130

Human   129 YHNNNQFFHDVEVEDVLPSSKRSPSTATLSLPSLEAYRDPSCLSPASSLSSRSCNSEASSYESNY 193
            :|.:|||||||||||||||.|||||||||.|||||||||||||||||||||||||||||||||||
  Rat   131 HHGSNQFFHDVEVEDVLPSCKRSPSTATLHLPSLEAYRDPSCLSPASSLSSRSCNSEASSYESNY 195

Human   194 SYPYASPQTSPWQSPCVSPKTTDPEEGFPRGLGACTLLGSPRHSPSTSPRASVTEESWLGARSSR 258
            ||||||||||||||||||||||||||||||.||||.||||||||||||||||||||||||||.||
  Rat   196 SYPYASPQTSPWQSPCVSPKTTDPEEGFPRSLGACHLLGSPRHSPSTSPRASVTEESWLGARGSR 260

Human   259 PASPCNKRKYSLNGRQPPYSPHHSPTPSPHGSPRVSVTDDSWLGNTTQYTSSAIVAAINALTTDS 323
            |.|||||||||||||||..|||||||||||||||||||:|:||||||||||||||||||||||||
  Rat   261 PTSPCNKRKYSLNGRQPSCSPHHSPTPSPHGSPRVSVTEDTWLGNTTQYTSSAIVAAINALTTDS 325

Human   324 SLDLGDGVPVKSRKTTLEQPPSVALKVEPVGEDLGSPPPPADFAPEDYSSFQHIRKGGFCDQYLA 388
            :||||||||:|||||.||..|||||||||.|||||:.||.:||.||:: :|||:|||.||:|||:
  Rat   326 TLDLGDGVPIKSRKTALEHVPSVALKVEPAGEDLGTTPPTSDFPPEEF-AFQHLRKGAFCEQYLS 389

Human   389 VPQHPYQWAKPKPLSPTSYMSPTLPALDWQLPSHSGPYELRIEVQPKSHHRAHYETEGSRGAVKA 453
            |||..|||||||.|||||||||:||||||||||||||||||||||||||||||||||||||||||
  Rat   390 VPQASYQWAKPKSLSPTSYMSPSLPALDWQLPSHSGPYELRIEVQPKSHHRAHYETEGSRGAVKA 454

Human   454 SAGGHPIVQLHGYLENEPLMLQLFIGTADDRLLRPHAFYQVHRITGKTVSTTSHEAILSNTKVLE 518
            ||||||:||||||||||||.|||||||||||||||||||||||||||||||||||||||||||||
  Rat   455 SAGGHPVVQLHGYLENEPLTLQLFIGTADDRLLRPHAFYQVHRITGKTVSTTSHEAILSNTKVLE 519

Human   519 IPLLPENSMRAVIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHVPQPSGRTLSLQVASN 583
            |||||||:|||:|||||||||||||||||||||||||||||||||||||:|||||||||||||||
  Rat   520 IPLLPENNMRAIIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHIPQPSGRTLSLQVASN 584

Human   584 PIECSQRSAQELPLVEKQSTDSYPVVGGKKMVLSGHNFLQDSKVIFVEKAPDGHHVWEMEAKTDR 648
            |||||||||||||||||||||||||:|||||||||||||||||||||||||||||||||||||||
  Rat   585 PIECSQRSAQELPLVEKQSTDSYPVIGGKKMVLSGHNFLQDSKVIFVEKAPDGHHVWEMEAKTDR 649

Human   649 DLCKPNSLVVEIPPFRNQRITSPVHVSFYVCNGKRKRSQYQRFTYLPANVPIIKTEPTDDYEPAP 713
            |||||||||:||||||||||||||.||||||||||||||||.||||||||||||||||||:|||.
  Rat   650 DLCKPNSLVLEIPPFRNQRITSPVQVSFYVCNGKRKRSQYQHFTYLPANVPIIKTEPTDDFEPAL 714

Human   714 TCGPVSQGLSPLPRPYYSQQLAMPPDPSSCLVAGFPPCPQRSTLMPAAPGVSPKLHDLSPAAYTK 778
            ||||:||||||||||||||||..||||.|||||||.||.||:||||.:|..||||||||..||.|
  Rat   715 TCGPMSQGLSPLPRPYYSQQLTAPPDPGSCLVAGFAPCSQRNTLMPTSPNASPKLHDLSSPAYAK 779

Human   779 GVASPGHC-HLGLPQPAGEAPAVQDVPRPVATHPGSPGQPPPALLPQQVSAPPSSSCPPGLEHSL 842
            |:|:|||. ||||..||.|||.:|::|||:|..|.||.||....|..|||...:||||.||:..|
  Rat   780 GLANPGHSGHLGLQPPASEAPTMQELPRPMAVQPNSPEQPTSVRLQPQVSPHLNSSCPLGLQQVL 844

Human   843 CPSSPSPPLPPATQEPTCLQPCSPACPPATGRPQHLPSTVRRDESPTAGPRLLPEVHEDGSPNLA 907
            .|:|||.|||||..|||||||  .|.||..|..|..|..|.|:|||:    :||||.||...|||
  Rat   845 YPNSPSSPLPPAAHEPTCLQP--SALPPDVGHRQQQPQKVHRNESPS----ILPEVCEDSDHNLA 903

Human   908 PIPVTVKREPEELDQLYLDDVNEIIRNDLSSTSTHS 943
            |:||.:|:||||||||||||||||||||||||..||
  Rat   904 PVPVVIKQEPEELDQLYLDDVNEIIRNDLSSTIPHS 939

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NFATC1	NP_001265598.1	PHA03247	<7..446	CDD:223021	376/440 (85%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	22..48		20/25 (80%)
		Calcineurin-binding	118..123		4/4 (100%)
		Transactivation domain A (TAD-A)	126..218		86/91 (95%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	200..298		91/97 (94%)
		3 X SP repeats	203..298		88/94 (94%)
		Nuclear localization signal	265..267		1/1 (100%)
		Nuclear export signal	310..321		10/10 (100%)
		RHD-n_NFAT	416..590	CDD:143641	168/173 (97%)
		IPT	595..695	CDD:472823	95/99 (96%)
		Nuclear localization signal	682..684		1/1 (100%)
		Transactivation domain B (TAD-B)	703..943		159/240 (66%)
		PHA03247	<712..890	CDD:223021	114/178 (64%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	787..912		68/124 (55%)
		Nuclear export signal	924..933		8/8 (100%)
Nfatc1	NP_001402650.1	RHD-n_NFAT	417..591	CDD:143641	168/173 (97%)
		IPT	596..696	CDD:472823	95/99 (96%)