DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17829 and ZNF551

DIOPT Version :9

Sequence 1:	NP_652054.1	Gene:	CG17829 / 47718	FlyBaseID:	FBgn0025635	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	NP_612356.2	Gene:	ZNF551 / 90233	HGNCID:	25108	Length:	670	Species:	Homo sapiens

Alignment Length:	434	Identity:	94/434 - (21%)
Similarity:	148/434 - (34%)	Gaps:	121/434 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 DHLEHYAKAQDDRGAHAEHTEHQCTWNSCDFRTENQVEFERHSYYH-GYY------LNLLLQ--- 102
            |.|:|.|....:. .|:..::|            .|..|...|||. |.|      .:.|:|
Human   192 DLLQHEATPSGEE-PHSSSSKH------------IQAFFNAKSYYKWGEYRKASSHKHTLVQHQS 243

  Fly   103 -----GKLECDLHPEIPACTAPARLMEKLPALGQNFRCGWTDCEREFVSIVEFQDHIVKHALFEY 162
                 |..||....:...|.......:::....:.|.|  ::||..|..    :.|::.|.:...
Human   244 VCSEGGLYECSKCEKAFTCKNTLVQHQQIHTGQKMFEC--SECEESFSK----KCHLILHKIIHT 302

  Fly   163 DIQKTPEDERPKTMCN------------------WAMCHKHMGNKYRLIEHISTHSNKKQVACFH 209
            ..:.....:|.|...:                  ...|.|....|..||||...|:.::...|..
Human   303 GERPYECSDREKAFIHKSEFIHHQRRHTGGVRHECGECRKTFSYKSNLIEHQRVHTGERPYECGE 367

  Fly   210 CGELFRTKTTLFDHLR--------------------------RQPENNTNSFQCAQCFKFFATKK 248
            ||:.||..::||.|.|                          |:.......:||:.|.|.|:.|.
Human   368 CGKSFRQSSSLFRHQRVHSGERPYQCCECGKSFRQIFNLIRHRRVHTGEMPYQCSDCGKSFSCKS 432

  Fly   249 LLKSH------------------------VVRHVNC------YKCTMCDMTCSSASSLTTHIRYR 283
            .|..|                        ::||.:.      |:|:.|:.:.|....|..|.|.
Human   433 ELIQHQRIHSGERPYECRECGKSFRQFSNLIRHRSIHTGDRPYECSECEKSFSRKFILIQHQRV- 496

  Fly   284 HLKDKPLKCSECDTRCVRESDLAKHVQIVHSKTVHQCEHPDCHYSVRTYTQMRRHFLEVHGNNPI 348
            |..::|.:||||.....|:|||.:|.:|......::|.  :|..|.|..:.:.:|.....|..|
Human   497 HTGERPYECSECGKSFTRKSDLIQHRRIHTGTRPYECS--ECGKSFRQRSGLIQHRRLHTGERP- 558

  Fly   349 LYACHCCERFFKSGKSLSAHLMKKHGFRLPSGHKRFTYRVDENG 392
             |.|..|.:.|....||..|.      |:.:|.:  .|...|.|
Human   559 -YECSECGKSFSQSASLIQHQ------RVHTGER--PYECSECG 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17829	NP_652054.1	C2H2 Zn finger	182..199	CDD:275368	7/16 (44%)
		C2H2 Zn finger	207..225	CDD:275368	8/17 (47%)
		C2H2 Zn finger	237..257	CDD:275368	7/43 (16%)
		C2H2 Zn finger	263..284	CDD:275368	6/20 (30%)
		C2H2 Zn finger	292..311	CDD:275368	9/18 (50%)
		C2H2 Zn finger	352..373	CDD:275368	6/20 (30%)
ZNF551	NP_612356.2	KRAB	29..>71	CDD:214630
		KRAB	29..68	CDD:279668
		C2H2 Zn finger	253..273	CDD:275368	2/19 (11%)
		COG5048	279..624	CDD:227381	75/334 (22%)
		C2H2 Zn finger	281..301	CDD:275368	6/25 (24%)
		C2H2 Zn finger	311..329	CDD:275368	2/17 (12%)
		C2H2 Zn finger	337..357	CDD:275368	7/19 (37%)
		zf-H2C2_2	349..374	CDD:290200	9/24 (38%)
		C2H2 Zn finger	365..385	CDD:275368	9/19 (47%)
		zf-H2C2_2	377..402	CDD:290200	4/24 (17%)
		C2H2 Zn finger	393..413	CDD:275368	1/19 (5%)
		zf-H2C2_2	405..430	CDD:290200	6/24 (25%)
		C2H2 Zn finger	421..441	CDD:275368	7/19 (37%)
		zf-H2C2_2	433..458	CDD:290200	2/24 (8%)
		C2H2 Zn finger	449..469	CDD:275368	2/19 (11%)
		zf-H2C2_2	461..486	CDD:290200	5/24 (21%)
		C2H2 Zn finger	477..497	CDD:275368	6/20 (30%)
		zf-H2C2_2	490..514	CDD:290200	9/24 (38%)
		C2H2 Zn finger	505..525	CDD:275368	9/19 (47%)
		zf-H2C2_2	517..542	CDD:290200	7/26 (27%)
		C2H2 Zn finger	533..553	CDD:275368	5/21 (24%)
		zf-H2C2_2	546..570	CDD:290200	7/25 (28%)
		C2H2 Zn finger	561..581	CDD:275368	7/25 (28%)
		zf-H2C2_2	573..598	CDD:290200	8/29 (28%)
		C2H2 Zn finger	589..609	CDD:275368	2/5 (40%)
		C2H2 Zn finger	617..637	CDD:275368
		zf-H2C2_2	629..654	CDD:290200
		C2H2 Zn finger	645..665	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910