DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17829 and ZNF628

DIOPT Version :9

Sequence 1:	NP_652054.1	Gene:	CG17829 / 47718	FlyBaseID:	FBgn0025635	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	NP_149104.3	Gene:	ZNF628 / 89887	HGNCID:	28054	Length:	1059	Species:	Homo sapiens

Alignment Length:	415	Identity:	88/415 - (21%)
Similarity:	124/415 - (29%)	Gaps:	144/415 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 RPQSSVPAPQPPGKRKKPAELELTCGWRDCQEICTGEWSLNGHIGDHLEHYAKAQDDRGAHAEHT 67
            :|.|.:|.|.||.....|....|.||
Human   337 QPPSPLPQPPPPAAAPAPGFACLPCG--------------------------------------- 362

  Fly    68 EHQCTWNSCDFRTENQVEFERHSYYHGYYLNLLLQGKLECDLHPEIPACTAPARLMEKLPALGQN 132
                    ..|||  .....||.:.||                                .|.||.
Human   363 --------KSFRT--VAGLSRHQHSHG--------------------------------AAGGQA 385

  Fly   133 FRCGWTDCEREFVSIVEFQDHIVKHALFEYDIQKTPEDERPKTMCNWAMCHKHMGNKYRLIEHI- 196
            ||||  .|:..|..:.....|...|.......:..|:.|..:..|..              |.:
Human   386 FRCG--SCDGSFPQLASLLAHQQCHVEEAAAGRPPPQAEAAEVTCPQ--------------EPLA 434

  Fly   197 -----------STHSNKKQVACFHCGELFRTKTTLFDHLRRQPENNTNSFQCAQCFKFFATKKLL 250
                       :..|.::...|..||:.|:..:.|..|||  .......:||.:|.|.|....||
Human   435 PAAPVPPPPPSAPASAERPYKCAECGKSFKGSSGLRYHLR--DHTGERPYQCGECGKAFKRSSLL 497

  Fly   251 KSHVVRH--VNCYKCTMCDMTCSSASSLTTHIRYRHLKDKPLKCSEC-----DTRCVRESDLAKH 308
            ..|...|  :..:.|..|.:|...:|....|:|. |..::|..|.||     :|.|:|     :|
Human   498 AIHQRVHTGLRAFTCGQCGLTFKWSSHYQYHLRL-HSGERPYACGECGKAFRNTSCLR-----RH 556

  Fly   309 VQIVHSKTVHQCEHPD----CHYSVRTYTQMRRHFLEVH-GNNPILYACHCCERFFKSGKSLSAH 368
                  :.||..|.|.    |..|....:.:|:| ..|| |..|  :.|..|.:.|....:|..|
Human   557 ------RHVHTGERPHACGVCGKSFAQTSNLRQH-QRVHTGERP--FRCPLCPKTFTHSSNLLLH 612

  Fly   369 LMKKHGFRLPSGHKRFTYRVDENGF 393
            .      |..|..:.||..:...||
Human   613 Q------RTHSAERPFTCPICGRGF 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17829	NP_652054.1	C2H2 Zn finger	182..199	CDD:275368	1/28 (4%)
		C2H2 Zn finger	207..225	CDD:275368	6/17 (35%)
		C2H2 Zn finger	237..257	CDD:275368	7/19 (37%)
		C2H2 Zn finger	263..284	CDD:275368	6/20 (30%)
		C2H2 Zn finger	292..311	CDD:275368	7/23 (30%)
		C2H2 Zn finger	352..373	CDD:275368	5/20 (25%)
ZNF628	NP_149104.3	C2H2 Zn finger	38..58	CDD:275368
		COG5048	<43..213	CDD:227381
		C2H2 Zn finger	66..86	CDD:275368
		C2H2 Zn finger	94..114	CDD:275368
		C2H2 Zn finger	122..142	CDD:275368
		C2H2 Zn finger	150..170	CDD:275368
		C2H2 Zn finger	178..198	CDD:275368
		zf-C2H2	204..226	CDD:306579
		C2H2 Zn finger	206..226	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	226..247
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	260..280
		C2H2 Zn finger	297..314	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	312..351		6/13 (46%)
		C2H2 Zn finger	361..378	CDD:275370	7/65 (11%)
		C2H2 Zn finger	388..408	CDD:275368	5/21 (24%)
		COG5048	<453..642	CDD:227381	55/202 (27%)
		C2H2 Zn finger	456..476	CDD:275368	8/21 (38%)
		C2H2 Zn finger	484..504	CDD:275368	7/19 (37%)
		C2H2 Zn finger	512..532	CDD:275368	6/20 (30%)
		C2H2 Zn finger	540..560	CDD:275368	7/30 (23%)
		C2H2 Zn finger	568..588	CDD:275368	4/20 (20%)
		C2H2 Zn finger	596..616	CDD:275368	6/25 (24%)
		C2H2 Zn finger	624..644	CDD:275368	2/8 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	644..674
		4 X approximate tandem repeats. /evidence=ECO:0000250\|UniProtKB:Q8CJ78	818..864
		Interaction with TAF4B. /evidence=ECO:0000250\|UniProtKB:Q8CJ78	943..1059
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910