DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17829 and ZNF668

DIOPT Version :9

Sequence 1:	NP_652054.1	Gene:	CG17829 / 47718	FlyBaseID:	FBgn0025635	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	NP_001166140.1	Gene:	ZNF668 / 79759	HGNCID:	25821	Length:	642	Species:	Homo sapiens

Alignment Length:	411	Identity:	90/411 - (21%)
Similarity:	137/411 - (33%)	Gaps:	108/411 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 YAKAQDDRGAHAEH---------TEHQCTWNSCDFRTENQVEFERHSYYHGYYLNLLLQGKLEC- 107
            :.||.:...|.|..         ..::|.  ||.....|.....||:..|         |..:|
Human    20 FTKAMEVEAAEARSPAPGYKRSGRRYKCL--SCTKTFPNAPRAARHAATH---------GPADCS 73

  Fly   108 ----DLHPE--------------------------IPACTAPARLMEKLPALGQN------FRCG 136
                ::.|:                          .|.|....:...:|.:.|::      |.|
Human    74 EEVAEVKPKPETEAKAEEASGEKVSGSAAKPRPYACPLCPKAYKTAPELRSHGRSHTGEKPFPC- 137

  Fly   137 WTDCEREFVSIVEFQDHIVKHALFEYDIQKTPEDERPKTMCNWAMCHKHMGNKYRLIEHISTHSN 201
             .:|.|.|:..|..:.|:..||           .|.| ..|  |.|.|..|...:|..|...|:.
Human   138 -PECGRRFMQPVCLRVHLASHA-----------GELP-FRC--AHCPKAYGALSKLKIHQRGHTG 187

  Fly   202 KKQVACFHCGELFRTKTTLFDHLRRQPENNTNSFQCAQCFKFFATKKLLKSHVVRHV--NCYKCT 264
            ::..||..||:.|...:....|  |:.......:.|.:|.|.:|..|.|::|...|.  ..:.|:
Human   188 ERPYACADCGKSFADPSVFRKH--RRTHAGLRPYSCERCGKAYAELKDLRNHERSHTGERPFLCS 250

  Fly   265 MCDMTCSSASSLTTHIRYRHLKDKPLKCSECDTRCVRESDLAKHVQIVHSKTVHQCEHPDCHYSV 329
            .|..:.|.:||||.|.|. |...||.:|..|.....:.|....|.:....:....|  |.|....
Human   251 ECGKSFSRSSSLTCHQRI-HAAQKPYRCPACGKGFTQLSSYQSHERTHSGEKPFLC--PRCGRMF 312

  Fly   330 RTYTQMRRHFLEVHGNNPILYACHCCERFFKSGKSLSAHL-----------------------MK 371
            ...:..|||.....|..|  |.|..|.:.|:....|:.|.                       :|
Human   313 SDPSSFRRHQRAHEGVKP--YHCEKCGKDFRQPADLAMHRRVHTGDRPFKCLQCDKTFVASWDLK 375

  Fly   372 KHGFRLPSGHKRFTYRVDENG 392
            :|.. :.||.:.|  |.:|.|
Human   376 RHAL-VHSGQRPF--RCEECG 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17829	NP_652054.1	C2H2 Zn finger	182..199	CDD:275368	5/16 (31%)
		C2H2 Zn finger	207..225	CDD:275368	5/17 (29%)
		C2H2 Zn finger	237..257	CDD:275368	7/19 (37%)
		C2H2 Zn finger	263..284	CDD:275368	9/20 (45%)
		C2H2 Zn finger	292..311	CDD:275368	4/18 (22%)
		C2H2 Zn finger	352..373	CDD:275368	6/43 (14%)
ZNF668	NP_001166140.1	COG5048	103..437	CDD:227381	76/317 (24%)
		C2H2 Zn finger	109..129	CDD:275370	4/19 (21%)
		zf-H2C2_2	121..144	CDD:290200	6/24 (25%)
		C2H2 Zn finger	137..157	CDD:275368	6/21 (29%)
		C2H2 Zn finger	165..185	CDD:275368	7/21 (33%)
		zf-H2C2_2	178..201	CDD:290200	7/22 (32%)
		C2H2 Zn finger	193..213	CDD:275368	6/21 (29%)
		C2H2 Zn finger	221..241	CDD:275368	7/19 (37%)
		zf-H2C2_2	233..258	CDD:290200	5/24 (21%)
		C2H2 Zn finger	249..269	CDD:275368	9/20 (45%)
		COG5048	271..618	CDD:227381	28/130 (22%)
		C2H2 Zn finger	277..297	CDD:275368	4/19 (21%)
		zf-H2C2_2	289..313	CDD:290200	4/25 (16%)
		C2H2 Zn finger	305..325	CDD:275368	6/21 (29%)
		zf-H2C2_2	317..342	CDD:290200	9/26 (35%)
		C2H2 Zn finger	333..353	CDD:275368	5/19 (26%)
		zf-H2C2_2	345..369	CDD:290200	2/23 (9%)
		C2H2 Zn finger	361..381	CDD:275368	2/20 (10%)
		zf-H2C2_2	373..397	CDD:290200	8/24 (33%)
		C2H2 Zn finger	389..409	CDD:275368	2/5 (40%)
		zf-H2C2_2	401..425	CDD:290200
		C2H2 Zn finger	417..437	CDD:275368
		C2H2 Zn finger	541..561	CDD:275368
		zf-H2C2_2	554..577	CDD:290200
		C2H2 Zn finger	569..589	CDD:275368
		zf-H2C2_2	582..606	CDD:290200
		C2H2 Zn finger	597..617	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910