DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17829 and ZNF175

DIOPT Version :9

Sequence 1:	NP_652054.1	Gene:	CG17829 / 47718	FlyBaseID:	FBgn0025635	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	NP_009078.1	Gene:	ZNF175 / 7728	HGNCID:	12964	Length:	711	Species:	Homo sapiens

Alignment Length:	394	Identity:	85/394 - (21%)
Similarity:	145/394 - (36%)	Gaps:	88/394 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 ELTCGWRDCQEICTGEWSLNGHIGDHLEHYAKAQD-----------------DRGAHAEHTEHQC 71
            |..|....|:::|..:.||.    .|..|..|..|                 .:..|:....|:|
Human   249 ETFCKGNQCRKVCGHKQSLK----QHQIHTQKKPDGCSECGGSFTQKSHLFAQQRIHSVGNLHEC 309

  Fly    72 TWNSCDFRTENQVEFERHSYYHGYYLNLLLQGKLECDLHPEIPACTAPARLM---------EKLP 127
              ..|......|::...:...|        .|.:.|       .|....::.         :|..
Human   310 --GKCGKAFMPQLKLSVYLTDH--------TGDIPC-------ICKECGKVFIQRSELLTHQKTH 357

  Fly   128 ALGQNFRCGWTDCEREFVSIVEFQDHIVKHALFEYDIQKTPEDERPKTMCNWAMCHKHMGNKYRL 192
            ...:.::|  .||.:.|..::         :||.:  |:|...|:   :...:.|.|.......|
Human   358 TRKKPYKC--HDCGKAFFQML---------SLFRH--QRTHSREK---LYECSECGKGFSQNSTL 406

  Fly   193 IEHISTHSNKKQVACFHCGELFRTKTTLFDHLRRQPENNTNSFQCAQCFKFFATKKLLKSHVVRH 257
            |.|...|:.::|.||..||:.|..|:||  .|.::..:...|:.|.:|.:.|    :.|:|::.|
Human   407 IIHQKIHTGERQYACSECGKAFTQKSTL--SLHQRIHSGQKSYVCIECGQAF----IQKAHLIVH 465

  Fly   258 VNC------YKCTMCDMTCSSASSLTTHIRYRHLKDKPLKCSECDTRCVRESDLAKHVQIVHSKT 316
            ...      |:|..|..:..|.|.|..|.|. |..:||.:||:|.....::|.|..|.:|...:.
Human   466 QRSHTGEKPYQCHNCGKSFISKSQLDIHHRI-HTGEKPYECSDCGKTFTQKSHLNIHQKIHTGER 529

  Fly   317 VHQCEHPDCHYSVRTYTQMRRHFLEVH-GNNPILYACHCCERFFKSGKSLSAHLMKKHGFRLPSG 380
            .|.|......::.::...|.:   .:| |..|  |.|..|.:.|.|......|.      |:.:|
Human   530 HHVCSECGKAFNQKSILSMHQ---RIHTGEKP--YKCSECGKAFTSKSQFKEHQ------RIHTG 583

  Fly   381 HKRF 384
            .|.:
Human   584 EKPY 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17829	NP_652054.1	C2H2 Zn finger	182..199	CDD:275368	5/16 (31%)
		C2H2 Zn finger	207..225	CDD:275368	7/17 (41%)
		C2H2 Zn finger	237..257	CDD:275368	5/19 (26%)
		C2H2 Zn finger	263..284	CDD:275368	7/20 (35%)
		C2H2 Zn finger	292..311	CDD:275368	6/18 (33%)
		C2H2 Zn finger	352..373	CDD:275368	5/20 (25%)
ZNF175	NP_009078.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		KRAB	27..85	CDD:214630
		C2H2 Zn finger	230..246	CDD:275368
		C2H2 Zn finger	255..273	CDD:275368	5/21 (24%)
		COG5048	275..689	CDD:227381	77/364 (21%)
		C2H2 Zn finger	281..300	CDD:275368	0/18 (0%)
		C2H2 Zn finger	309..329	CDD:275368	3/21 (14%)
		C2H2 Zn finger	337..357	CDD:275368	2/19 (11%)
		Nuclear localization signal. /evidence=ECO:0000255	359..362		0/2 (0%)
		C2H2 Zn finger	365..385	CDD:275368	7/32 (22%)
		C2H2 Zn finger	393..413	CDD:275368	5/19 (26%)
		C2H2 Zn finger	421..441	CDD:275368	8/21 (38%)
		C2H2 Zn finger	449..469	CDD:275368	6/23 (26%)
		C2H2 Zn finger	477..497	CDD:275368	7/20 (35%)
		C2H2 Zn finger	505..525	CDD:275368	6/19 (32%)
		C2H2 Zn finger	533..553	CDD:275368	2/22 (9%)
		C2H2 Zn finger	561..581	CDD:275368	6/25 (24%)
		C2H2 Zn finger	589..609	CDD:275368
		C2H2 Zn finger	617..637	CDD:275368
		C2H2 Zn finger	645..665	CDD:275368
		C2H2 Zn finger	673..693	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910