DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17829 and MZF1

DIOPT Version :9

Sequence 1:	NP_652054.1	Gene:	CG17829 / 47718	FlyBaseID:	FBgn0025635	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	XP_005259261.1	Gene:	MZF1 / 7593	HGNCID:	13108	Length:	775	Species:	Homo sapiens

Alignment Length:	360	Identity:	88/360 - (24%)
Similarity:	130/360 - (36%)	Gaps:	67/360 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 CQEICTGEWSLNGHIGDH-LEH-----------------YAKAQDDRGAHAEHTEHQCTWNSCDF 78
            |.| |...:|.:.|:..| |.|                 .|:.::.|..|......:|......|
Human   427 CSE-CGRSFSRSSHLLRHQLTHTEERPFVCGDCGQGFVRSARLEEHRRVHTGEQPFRCAECGQSF 490

  Fly    79 RTENQVEFERHSYYHGYYLNLLLQGKLECDLHPEIPACTAPARLMEKLPALGQNFRCGWTDCERE 143
            |..:.:  .:|...||               .|..|....||  ....|.....|.|  ::|...
Human   491 RQRSNL--LQHQRIHG---------------DPPGPGAKPPA--PPGAPEPPGPFPC--SECRES 534

  Fly   144 FVSIVEFQDHIVKHALFEYDIQKTPEDERPKTM-CNWAMCHKHMGNKYRLIEHISTHSNKKQVAC 207
            |.......:|...|.             ..|:. |  ..|.:..|.:..|::|...||.::..||
Human   535 FARRAVLLEHQAVHT-------------GDKSFGC--VECGERFGRRSVLLQHRRVHSGERPFAC 584

  Fly   208 FHCGELFRTKTTLFDHLRRQPENNTNSFQCAQCFKFFATKKLLKSHVVRHV--NCYKCTMCDMTC 270
            ..||:.||.::.|..|  |:.......|.||:|.|.|..:..|..|:..|.  ..:.|..|....
Human   585 AECGQSFRQRSNLTQH--RRIHTGERPFACAECGKAFRQRPTLTQHLRVHTGEKPFACPECGQRF 647

  Fly   271 SSASSLTTHIRYRHLKDKPLKCSECDTRCVRESDLAKHVQIVHSKTVHQCEHPDCHYSVRTYTQM 335
            |....||.|.| .|..:||..|.||.....:.|.|.:|.:|...:....|  |:|..|.|.:..:
Human   648 SQRLKLTRHQR-THTGEKPYHCGECGLGFTQVSRLTEHQRIHTGERPFAC--PECGQSFRQHANL 709

  Fly   336 RRHFLEVH-GNNPILYACHCCERFFKSGKSLSAHL 369
            .:| ..:| |..|  |||..|.:.|:...:|:.||
Human   710 TQH-RRIHTGERP--YACPECGKAFRQRPTLTQHL 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17829	NP_652054.1	C2H2 Zn finger	182..199	CDD:275368	4/16 (25%)
		C2H2 Zn finger	207..225	CDD:275368	7/17 (41%)
		C2H2 Zn finger	237..257	CDD:275368	7/19 (37%)
		C2H2 Zn finger	263..284	CDD:275368	7/20 (35%)
		C2H2 Zn finger	292..311	CDD:275368	6/18 (33%)
		C2H2 Zn finger	352..373	CDD:275368	6/18 (33%)
MZF1	XP_005259261.1	SCAN	81..193	CDD:128708
		COG5048	399..757	CDD:227381	88/360 (24%)
		C2H2 Zn finger	399..419	CDD:275368
		C2H2 Zn finger	427..447	CDD:275368	7/20 (35%)
		C2H2 Zn finger	455..475	CDD:275368	2/19 (11%)
		C2H2 Zn finger	483..503	CDD:275370	4/21 (19%)
		C2H2 Zn finger	528..548	CDD:275368	4/21 (19%)
		C2H2 Zn finger	556..576	CDD:275368	5/21 (24%)
		C2H2 Zn finger	584..604	CDD:275368	8/21 (38%)
		C2H2 Zn finger	612..632	CDD:275368	7/19 (37%)
		C2H2 Zn finger	640..660	CDD:275368	7/20 (35%)
		C2H2 Zn finger	668..688	CDD:275368	6/19 (32%)
		C2H2 Zn finger	696..716	CDD:275368	6/22 (27%)
		C2H2 Zn finger	724..744	CDD:275368	6/18 (33%)
		C2H2 Zn finger	752..772	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910