DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17829 and ZNF624

DIOPT Version :9

Sequence 1:	NP_652054.1	Gene:	CG17829 / 47718	FlyBaseID:	FBgn0025635	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	NP_065838.2	Gene:	ZNF624 / 57547	HGNCID:	29254	Length:	865	Species:	Homo sapiens

Alignment Length:	399	Identity:	104/399 - (26%)
Similarity:	150/399 - (37%)	Gaps:	89/399 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 KKPAELELTCG--------WRDCQEICTGE--WSLNGHIGDHLEHYAKAQDDRGAHAEHTEHQCT 72
            :||.|.. .||        :.:.|.|.|||  :..| ..|....:|:........|.....::||
Human   497 EKPYECN-ECGKAFNRIANFTEHQRIHTGEKPYKCN-ECGKAFINYSCLTVHHRMHTGEKPYKCT 559

  Fly    73 WNSCD---FRTENQVEFER-HSYYHGYYLNLLLQGKLEC----------DLHPEIPACTAPARLM 123
              .|.   .|:.:.:..:| |:....|..|       ||          .:|..|.....|
Human   560 --ECGKAFMRSSSLIIHQRIHTEEKPYLCN-------ECGESFRIKSHLTVHQRIHTGEKP---- 611

  Fly   124 EKLPALGQNFRCGWTDCEREFVSIVEFQDHIVKHALFE----YDI-------------QKTPEDE 171
                     ::|  |||||.|..:|..::|...|...:    ||.             |:|...|
Human   612 ---------YKC--TDCERAFTKMVNLKEHQKIHTGVKPYKCYDCGKSFRTKSYLIVHQRTHTGE 665

  Fly   172 RPKTMCNWAMCHKHMGNKYRLIEHISTHSNKKQVACFHCGELFRTKTTLFDHLRRQPENNTNSFQ 236
            :| ..||  .|.|...|..:|..|...|:.:|...|..||::|.:.:....|.|  .......|:
Human   666 KP-YKCN--ECEKAFTNTSQLTVHQRRHTGEKPYKCNECGKVFTSNSGFNTHQR--THTGEKPFK 725

  Fly   237 CAQCFKFFATKKLLKSHVVRHVNC------YKCTMCDMTCSSASSLTTHIRYRHLKDKPLKCSEC 295
            |..|.|.|:.    ..||..|...      |||.:|.......|.||.|.| .|..:||..|.||
Human   726 CNDCGKAFSQ----MVHVTEHQKIHSGEKPYKCDVCGKAFRRGSYLTVHWR-THTGEKPYTCKEC 785

  Fly   296 DTRCVRESDLAKHVQIVHSKTVHQCEHPDCHYSVRTYTQMRRHFLEVH-GNNPILYACHCCERFF 359
            ...|:..|.|..|.:|...:..::||  :|..:.||.:....| |.:| |..|  |.|:.|.:.|
Human   786 GKGCITLSQLTLHQRIHTGERPYKCE--ECGKAFRTNSDFTVH-LRMHTGEKP--YKCNECGKAF 845

  Fly   360 KSGKSLSAH 368
            :|..||:.|
Human   846 RSSSSLTVH 854

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17829	NP_652054.1	C2H2 Zn finger	182..199	CDD:275368	5/16 (31%)
		C2H2 Zn finger	207..225	CDD:275368	5/17 (29%)
		C2H2 Zn finger	237..257	CDD:275368	6/19 (32%)
		C2H2 Zn finger	263..284	CDD:275368	7/20 (35%)
		C2H2 Zn finger	292..311	CDD:275368	7/18 (39%)
		C2H2 Zn finger	352..373	CDD:275368	7/17 (41%)
ZNF624	NP_065838.2	KRAB	54..114	CDD:214630
		KRAB	54..93	CDD:279668
		C2H2 Zn finger	254..270	CDD:275368
		COG5048	<268..463	CDD:227381
		C2H2 Zn finger	278..298	CDD:275368
		zf-H2C2_2	291..315	CDD:290200
		C2H2 Zn finger	306..326	CDD:275368
		zf-H2C2_2	318..341	CDD:290200
		C2H2 Zn finger	334..354	CDD:275368
		zf-H2C2_2	346..371	CDD:290200
		C2H2 Zn finger	362..381	CDD:275368
		zf-H2C2_2	375..398	CDD:290200
		zf-C2H2	388..410	CDD:278523
		C2H2 Zn finger	390..410	CDD:275368
		zf-H2C2_2	403..427	CDD:290200
		COG5048	414..826	CDD:227381	91/366 (25%)
		C2H2 Zn finger	418..438	CDD:275368
		zf-H2C2_2	430..455	CDD:290200
		C2H2 Zn finger	446..466	CDD:275368
		zf-H2C2_2	459..483	CDD:290200
		C2H2 Zn finger	474..494	CDD:275368
		zf-H2C2_2	486..511	CDD:290200	5/14 (36%)
		C2H2 Zn finger	502..522	CDD:275368	3/20 (15%)
		zf-H2C2_2	514..537	CDD:290200	7/23 (30%)
		C2H2 Zn finger	530..550	CDD:275368	3/20 (15%)
		zf-H2C2_2	543..565	CDD:290200	4/23 (17%)
		C2H2 Zn finger	558..578	CDD:275368	5/21 (24%)
		C2H2 Zn finger	586..606	CDD:275368	4/26 (15%)
		zf-H2C2_2	598..622	CDD:290200	9/38 (24%)
		C2H2 Zn finger	614..634	CDD:275368	9/21 (43%)
		zf-H2C2_2	626..651	CDD:290200	4/24 (17%)
		C2H2 Zn finger	642..662	CDD:275368	3/19 (16%)
		zf-H2C2_2	654..679	CDD:290200	8/27 (30%)
		C2H2 Zn finger	670..690	CDD:275368	7/21 (33%)
		zf-H2C2_2	683..707	CDD:290200	8/23 (35%)
		C2H2 Zn finger	698..718	CDD:275368	6/21 (29%)
		zf-H2C2_2	711..735	CDD:290200	7/25 (28%)
		C2H2 Zn finger	726..746	CDD:275368	7/23 (30%)
		zf-H2C2_2	738..763	CDD:290200	7/24 (29%)
		C2H2 Zn finger	754..774	CDD:275368	7/20 (35%)
		C2H2 Zn finger	782..802	CDD:275368	7/19 (37%)
		zf-H2C2_2	795..819	CDD:290200	6/25 (24%)
		C2H2 Zn finger	810..830	CDD:275368	7/22 (32%)
		zf-H2C2_2	822..847	CDD:290200	9/27 (33%)
		C2H2 Zn finger	838..858	CDD:275368	7/17 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910