DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17829 and prdm9

DIOPT Version :9

Sequence 1:	NP_652054.1	Gene:	CG17829 / 47718	FlyBaseID:	FBgn0025635	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	NP_957196.1	Gene:	prdm9 / 393876	ZFINID:	ZDB-GENE-040426-1319	Length:	853	Species:	Danio rerio

Alignment Length:	495	Identity:	112/495 - (22%)
Similarity:	158/495 - (31%)	Gaps:	163/495 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 CQEICTGEWSLNGHIGDHLEHYAKAQD-DRGAHAEHTEHQCTWNSCDFRTENQVEFERH--SYYH 93
            |::..:....|..|...|.|.....:. ||.:..    :.||  .|......::...:|  .::|
Zfish   371 CKKCFSQATGLKRHQHTHQEQEKNIESPDRPSDI----YPCT--KCTLSFVAKINLHQHLKRHHH 429

  Fly    94 GYYLNLLLQGKLECDL---HPEI------PACTAPARLMEKL---------------------PA 128
            |.||.|:..|.|..:.   |.|:      |....|:|..:..                     |.
Zfish   430 GEYLRLVESGSLTAETEEDHTEVCFDKQDPNYEPPSRGRKSTKNSLKGRGCPKKVAVGRPRGRPP 494

  Fly   129 LGQNFR---------CGWTDCEREFVSIVEFQDH----------IVKH--------------ALF 160
            ..:|..         |  |:||:.|..:...:.|          .|:|              |..
Zfish   495 KNKNLEVEVQKISPIC--TNCEQSFSDLETLKTHQCPRRDDEGDNVEHPQEASQYICGECIRAFS 557

  Fly   161 EYDIQKTPE--------------DERPKTMCN----------------WAMCHKHMGNKYRLIEH 195
            ..|:.|..|              |.....|||                ..:|.|.......|..|
Zfish   558 NLDLLKAHECIQQGEGSYCCPHCDLYFNRMCNLRRHERTIHSKEKPYCCTVCLKSFTQSSGLKRH 622

  Fly   196 ISTHSNKKQ------------VACFHCGELFRTKTTLFDHLRR-QPENNTN--SFQ--------- 236
            ..:|..:|.            ..|.:|...|..:..|:.|:|| .||.:..  |||
Zfish   623 QQSHLRRKSHRQSSALFTAAIFPCAYCPFSFTDERYLYKHIRRHHPEMSLKYLSFQEGGVLSVEK 687

  Fly   237 ---CAQCFKFFATKKLLKSHVVRHVNCYK-------CTMCDMTCSSASSLTTHIRYRHLKDKPLK 291
               |:||.|.|:|.|..|:|     :|:|       |..|....|..:||..|.|. |..:||..
Zfish   688 PHSCSQCCKSFSTIKGFKNH-----SCFKQGEKVYLCPDCGKAFSWFNSLKQHQRI-HTGEKPYT 746

  Fly   292 CSECDTRCVRESDLAKHVQIVHSKTVHQCEHP----DCHYSVRTYTQMRRHFLEVHGNNPILYAC 352
            ||:|....|....|..|::      .|..|.|    .|..|.|....:|||..:..|..|    |
Zfish   747 CSQCGKSFVHSGQLNVHLR------THTGEKPFLCSQCGESFRQSGDLRRHEQKHSGVRP----C 801

  Fly   353 HC--CERFFKSGKSLSAHLMKKHGFRL-PSGH--KRFTYR 387
            .|  |.:.|...:||.||.....|.:| |...  |.||.|
Zfish   802 QCPDCGKSFSRPQSLKAHQQLHVGTKLFPCTQCGKSFTRR 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17829	NP_652054.1	C2H2 Zn finger	182..199	CDD:275368	4/16 (25%)
		C2H2 Zn finger	207..225	CDD:275368	5/17 (29%)
		C2H2 Zn finger	237..257	CDD:275368	9/19 (47%)
		C2H2 Zn finger	263..284	CDD:275368	7/20 (35%)
		C2H2 Zn finger	292..311	CDD:275368	6/18 (33%)
		C2H2 Zn finger	352..373	CDD:275368	8/22 (36%)
prdm9	NP_957196.1	PR-SET_PRDM7_9	79..207	CDD:380970
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q96EQ9	127..133
		S-adenosyl-L-methionine binding. /evidence=ECO:0000250\|UniProtKB:Q96EQ9	275..277
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	291..322
		COG5048	333..755	CDD:227381	83/397 (21%)
		C2H2 Zn finger	339..360	CDD:275368
		S-adenosyl-L-methionine binding. /evidence=ECO:0000250\|UniProtKB:Q96EQ9	341..342
		C2H2 Zn finger	368..388	CDD:275368	3/16 (19%)
		C2H2 Zn finger	407..427	CDD:275368	4/21 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	447..496		6/48 (13%)
		C2H2 Zn finger	549..569	CDD:275368	4/19 (21%)
		C2H2 Zn finger	577..598	CDD:275368	4/20 (20%)
		C2H2 Zn finger	606..626	CDD:275368	4/19 (21%)
		C2H2 Zn finger	646..666	CDD:275368	6/19 (32%)
		COG5048	<687..849	CDD:227381	53/171 (31%)
		C2H2 Zn finger	691..711	CDD:275368	10/24 (42%)
		C2H2 Zn finger	719..739	CDD:275368	7/20 (35%)
		C2H2 Zn finger	747..767	CDD:275368	6/25 (24%)
		DNA-binding. /evidence=ECO:0000250\|UniProtKB:Q9NQV7	755..845		29/97 (30%)
		C2H2 Zn finger	775..795	CDD:275368	6/19 (32%)
		C2H2 Zn finger	803..823	CDD:275368	7/19 (37%)
		C2H2 Zn finger	831..852	CDD:275368	4/11 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594152
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930