DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17829 and ZBTB49

DIOPT Version :9

Sequence 1:	NP_652054.1	Gene:	CG17829 / 47718	FlyBaseID:	FBgn0025635	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	NP_001317554.1	Gene:	ZBTB49 / 166793	HGNCID:	19883	Length:	765	Species:	Homo sapiens

Alignment Length:	391	Identity:	85/391 - (21%)
Similarity:	132/391 - (33%)	Gaps:	113/391 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 NLLLQGKLECDLHPEIPA-CTAPARLMEKLPAL---------GQNFRCGWTDCEREFVSIVEFQD 152
            |.|.|...:...|||..| |..|.:.|....|:         .|.:        .|.||..:..|
Human   275 NFLAQPVNDSAPHPESDATCQQPVKQMRLKKAIHLKKLNFLKSQKY--------AEQVSEPKSDD 331

  Fly   153 HIV-------KHALFEYDIQKTPEDERPKTM-CNWAMC---HKHMGNKYRLIEHISTHSNKKQVA 206
            .:.       |:.|.:...|...|.|..:.: |....|   .:...:...|.:...|..:::|.|
Human   332 GLTKRLESASKNTLEKASSQSAEEKESEEVVSCENFNCISETERPEDPAALEDQSQTLQSQRQYA 396

  Fly   207 CFHCGELFRTKTTLFDHLRRQPENNTNSFQCAQCFKFFATKKLLKSHVVRHVNCYKCTMCDMTCS 271
            |..||:.|:..:.|  .|.::.......|:|..|.|.|                          |
Human   397 CELCGKPFKHPSNL--ELHKRSHTGEKPFECNICGKHF--------------------------S 433

  Fly   272 SASSLTTHIRYRHLKDKPLKCSECDTRCVRESDLAKHVQIVHS-KTVHQC--------------E 321
            .|.:|.||:| ||..:||..|..|..|.....|:.:|: |:|| :..|.|              |
Human   434 QAGNLQTHLR-RHSGEKPYICEICGKRFAASGDVQRHI-IIHSGEKPHLCDICGRGFSNFSNLKE 496

  Fly   322 HPDCHYSVRTYT------------QMRRHFLEVHGNNPILYACHCCERFFKSGKSLSAHLMKKHG 374
            |...|.:.:.:|            ::.:|.:...|..|  |:|..|.:.|.....|..|:
Human   497 HKKTHTADKVFTCDECGKSFNMQRKLVKHRIRHTGERP--YSCSACGKCFGGSGDLRRHV----- 554

  Fly   375 FRLPSGHKRFTYRVDENGFYRLETTR----------------LESLE---VTQQILSPQVNDSLA 420
             |..:|.|.:|..:....|.|....|                ||.|.   .|..:...|.:||.:
Human   555 -RTHTGEKPYTCEICNKCFTRSAVLRRHKKMHCKAGDESPDVLEELSQAIETSDLEKSQSSDSFS 618

  Fly   421 K 421
            :
Human   619 Q 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17829	NP_652054.1	C2H2 Zn finger	182..199	CDD:275368	2/19 (11%)
		C2H2 Zn finger	207..225	CDD:275368	5/17 (29%)
		C2H2 Zn finger	237..257	CDD:275368	4/19 (21%)
		C2H2 Zn finger	263..284	CDD:275368	6/20 (30%)
		C2H2 Zn finger	292..311	CDD:275368	5/18 (28%)
		C2H2 Zn finger	352..373	CDD:275368	5/20 (25%)
ZBTB49	NP_001317554.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	165..203
ZBTB49	NP_001317554.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	275..294		7/18 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910