DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17829 and ZNF425

DIOPT Version :9

Sequence 1:	NP_652054.1	Gene:	CG17829 / 47718	FlyBaseID:	FBgn0025635	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	NP_001001661.1	Gene:	ZNF425 / 155054	HGNCID:	20690	Length:	752	Species:	Homo sapiens

Alignment Length:	588	Identity:	131/588 - (22%)
Similarity:	193/588 - (32%)	Gaps:	224/588 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLRPQSSVPAPQPPGK------RKKPAELELTCGWR--DCQEICTGEWSLNGHIGDHLEHYAKAQ 57
            :|..:.|:.|..|..|      |:.|..||:..|.|  .|. :|...:.:...:..|...::|:|
Human   153 ILNKKVSITAYDPDKKDLRHKPRETPGRLEIPTGPRCYSCY-VCRKVFQVRRDLLKHKRSHSKSQ 216

  Fly    58 ---------DDRG-AHAEHTEH--------QCTWNSCDFRTENQVEFERHSYYHGYYLNLLLQGK 104
                     ..|| :....|:.        ||  :.|:           .||:        |:|.
Human   217 LCRYPKYKNSSRGKSELRRTQRLLCQKKRFQC--SECE-----------KSYF--------LKGS 260

  Fly   105 L----------------ECD--------------LH-PEIPACTAPARLMEKLPALGQNFRCGWT 138
            |                |||              || .|.|.|                  ||
Human   261 LVTHQVVHTGQRPYPCPECDKTFRYRANLKKHLCLHRGERPFC------------------CG-- 305

  Fly   139 DCEREFVSIVEFQDHIVKHALFEYDIQKTPEDER----------------PKTMCNWAMCHKHMG 187
            :|.|.||...|..:|:..|: .|...| .|:.:|                .|...:...|.:...
Human   306 ECGRAFVQQCELTEHLRLHS-GEKPFQ-CPQCDRCFRLKRGMKVHLTQHSGKRPFHCPECGRSFS 368

  Fly   188 NKYRLIEHISTHSNKKQVACFHCGELFRTKTTLFDHLRRQPENNTNSFQCAQCFKFFATKKLLKS 252
            .|..|..|..|||.:|..:|..||..|..|..|.:|:|  .......|.|.:|.|.|..|:.||:
Human   369 RKAALKTHQRTHSEEKPFSCGECGRKFIYKIKLDEHIR--VHTGEKPFSCPECNKSFRLKRSLKA 431

  Fly   253 HVVRHVN------------------------------------------------C--------- 260
            |.::|:.                                                |
Human   432 HGLQHIGKRPFQCPECSRGFFWRNAMRAHQRLHSEQKPFPCAECGKRFTRPSKLACHTRVHDRQK 496

  Fly   261 -YKCTMCDMTCSSASSLTTHIRYRHLKDKPLKCSECDTRCVRESDLAKHVQIVHSKTVHQCEHPD 324
             :.|..|..|.|..|.||.|::. |..:||..|:||.....|.:.|.:|.::...:...||  |:
Human   497 EFPCGECKKTFSQQSRLTQHLKV-HTTEKPFSCAECGRSFRRRAHLTEHTRLHSGEEPFQC--PE 558

  Fly   325 CHYSV-------------------------RTYT---QMRRHFLEVH-GNNPILYACHCCERFFK 360
            |..|.                         :|||   |:..| |.:| |..|  |.|..||:.|:
Human   559 CDKSFSWKASMKFHQRMHRDEKPFACGECDKTYTHQSQLTEH-LRLHSGEKP--YQCPECEKTFR 620

  Fly   361 SGKSLSAHLMKKHGFRLPSGHKRFTYRVDENGF---YRL-ETTRLESLEVTQQILSPQVNDSLAK 421
            ...:|.:||::.      ||.|.|:..:....|   ||| |..|:.|.|...|  .|:.:.|...
Human   621 LKGNLKSHLLQH------SGQKPFSCVMCGKSFTQQYRLTEHIRVHSGEKPFQ--CPECDKSYCI 677

  Fly   422 PGT 424
            .|:
Human   678 RGS 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17829	NP_652054.1	C2H2 Zn finger	182..199	CDD:275368	4/16 (25%)
		C2H2 Zn finger	207..225	CDD:275368	7/17 (41%)
		C2H2 Zn finger	237..257	CDD:275368	8/19 (42%)
		C2H2 Zn finger	263..284	CDD:275368	8/20 (40%)
		C2H2 Zn finger	292..311	CDD:275368	6/18 (33%)
		C2H2 Zn finger	352..373	CDD:275368	7/20 (35%)
ZNF425	NP_001001661.1	KRAB	9..64	CDD:214630
		KRAB	9..48	CDD:279668
		C2H2 Zn finger	192..212	CDD:275368	3/20 (15%)
		C2H2 Zn finger	248..268	CDD:275368	7/40 (18%)
		C2H2 Zn finger	276..296	CDD:275368	3/19 (16%)
		C2H2 Zn finger	304..324	CDD:275368	8/21 (38%)
		C2H2 Zn finger	332..352	CDD:275368	2/19 (11%)
		COG5048	355..731	CDD:227381	83/342 (24%)
		zf-C2H2	358..380	CDD:278523	4/21 (19%)
		C2H2 Zn finger	360..380	CDD:275368	4/19 (21%)
		C2H2 Zn finger	388..408	CDD:275368	8/21 (38%)
		zf-H2C2_2	401..423	CDD:290200	7/23 (30%)
		C2H2 Zn finger	416..432	CDD:275368	7/15 (47%)
		C2H2 Zn finger	444..464	CDD:275368	0/19 (0%)
		C2H2 Zn finger	472..492	CDD:275368	1/19 (5%)
		C2H2 Zn finger	500..520	CDD:275368	8/20 (40%)
		C2H2 Zn finger	528..548	CDD:275368	6/19 (32%)
		zf-H2C2_2	540..564	CDD:290200	7/25 (28%)
		C2H2 Zn finger	556..576	CDD:275368	4/21 (19%)
		C2H2 Zn finger	584..604	CDD:275368	6/20 (30%)
		zf-H2C2_2	597..619	CDD:290200	9/24 (38%)
		C2H2 Zn finger	612..632	CDD:275368	7/19 (37%)
		C2H2 Zn finger	640..660	CDD:275368	6/19 (32%)
		zf-H2C2_2	653..675	CDD:290200	7/23 (30%)
		C2H2 Zn finger	668..688	CDD:275368	3/13 (23%)
		zf-H2C2_2	680..705	CDD:290200	0/1 (0%)
		C2H2 Zn finger	696..716	CDD:275368
		C2H2 Zn finger	724..744	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910