DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17829 and ZNF555

DIOPT Version :9

Sequence 1:	NP_652054.1	Gene:	CG17829 / 47718	FlyBaseID:	FBgn0025635	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	XP_011526018.1	Gene:	ZNF555 / 148254	HGNCID:	28382	Length:	630	Species:	Homo sapiens

Alignment Length:	382	Identity:	89/382 - (23%)
Similarity:	135/382 - (35%)	Gaps:	75/382 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 CQEICTGEWSLNGHIGDHLEHYAKAQDDRGAHAEHTEHQCTWNSCDFRTENQVEFERHSYYH-GY 95
            |:| |...:|.:.....|:.          :|.....|:|  ..|.........|.||...| |
Human   288 CKE-CAEAFSYSSTFRRHMI----------SHTGEKPHKC--KECGEAFSYSSAFRRHMITHTG- 338

  Fly    96 YLNLLLQGKLECDLHPEIPACTAPARLMEKLPALGQNFRCGWTDCEREFVSIVEFQDHIVKHALF 160
                  :...||....:........|..|::....:.:.|  ..|.:.|:....|:.|
Human   339 ------EKPYECKQCGKTFIYLQSFRRHERIHTGEKPYEC--KQCGKTFIYPQSFRRH------- 388

  Fly   161 EYDIQKTPEDERPK--TMCNWAMCHK---------HMGNK--------------YRLIEHISTHS 200
                ::|...|:|.  ..|..|..|.         |.|.|              ..|.:|:.||:
Human   389 ----ERTHGGEKPYECNQCGKAFSHPSSFRGHMRVHTGEKPYECKQCGKTFNWPISLRKHMRTHT 449

  Fly   201 NKKQVACFHCGELFRTKTTLFDHLRRQPENNTNSFQCAQCFKFFATKKLLKSHVVRHV--NCYKC 263
            .:|...|..||:.|.......:|:|..||:  .|::|..|.|.|.....|:.|:.||.  ..|||
Human   450 REKPYECKQCGKAFSLSACFREHVRMHPED--KSYECKLCGKAFYCHISLQKHMRRHTAEKLYKC 512

  Fly   264 TMCDMTCSSASSLTTHIRYRHLKDKPLKCSECDTRCVRESDLAKHVQIVHSKTVHQCEHPDCHYS 328
            ..|....|....|..|:| .|..:||.:|.||.......|.|..|:::...:..:||:|  |..:
Human   513 KQCGKAFSWPELLQQHVR-THTVEKPYECKECGKVFKWPSSLPIHMRLHTGEKPYQCKH--CGKA 574

  Fly   329 VRTYTQMRRHFLEVHGNNPILYAC---HCCERFFKSGKSLSAH----LMKKHGFRLP 378
            ....:.:||| :.:|.... .|.|   |.....|....|..:|    |:|.....||
Human   575 FNCSSSLRRH-VRIHTTEK-QYKCNVGHPPANEFMCSASEKSHQERDLIKVVNMVLP 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17829	NP_652054.1	C2H2 Zn finger	182..199	CDD:275368	6/39 (15%)
		C2H2 Zn finger	207..225	CDD:275368	5/17 (29%)
		C2H2 Zn finger	237..257	CDD:275368	6/19 (32%)
		C2H2 Zn finger	263..284	CDD:275368	6/20 (30%)
		C2H2 Zn finger	292..311	CDD:275368	6/18 (33%)
		C2H2 Zn finger	352..373	CDD:275368	7/27 (26%)
ZNF555	XP_011526018.1	KRAB	6..>50	CDD:214630
		KRAB	6..45	CDD:279668
		C2H2 Zn finger	151..168	CDD:275368
		C2H2 Zn finger	176..196	CDD:275368
		zf-H2C2_2	188..211	CDD:290200
		COG5048	200..597	CDD:227381	80/348 (23%)
		C2H2 Zn finger	204..224	CDD:275368
		zf-H2C2_2	216..239	CDD:290200
		C2H2 Zn finger	232..252	CDD:275368
		zf-H2C2_2	244..269	CDD:290200
		C2H2 Zn finger	260..280	CDD:275368
		zf-H2C2_2	273..297	CDD:290200	3/9 (33%)
		C2H2 Zn finger	288..308	CDD:275368	5/30 (17%)
		zf-H2C2_2	301..325	CDD:290200	5/35 (14%)
		C2H2 Zn finger	316..336	CDD:275368	5/21 (24%)
		zf-H2C2_2	328..353	CDD:290200	7/31 (23%)
		C2H2 Zn finger	344..364	CDD:275368	3/19 (16%)
		zf-H2C2_2	356..381	CDD:290200	5/26 (19%)
		C2H2 Zn finger	372..392	CDD:275368	5/32 (16%)
		zf-H2C2_2	384..409	CDD:290200	7/35 (20%)
		C2H2 Zn finger	400..420	CDD:275368	3/19 (16%)
		zf-H2C2_2	412..436	CDD:290200	3/23 (13%)
		C2H2 Zn finger	428..448	CDD:275368	2/19 (11%)
		zf-H2C2_2	440..464	CDD:290200	8/23 (35%)
		C2H2 Zn finger	456..476	CDD:275368	6/19 (32%)
		C2H2 Zn finger	484..504	CDD:275368	6/19 (32%)
		zf-H2C2_2	496..520	CDD:290200	8/23 (35%)
		C2H2 Zn finger	512..532	CDD:275368	6/20 (30%)
		zf-H2C2_2	525..548	CDD:290200	9/23 (39%)
		C2H2 Zn finger	540..560	CDD:275368	6/19 (32%)
		zf-H2C2_2	556..577	CDD:290200	5/22 (23%)
		C2H2 Zn finger	568..588	CDD:275368	6/22 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910