DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17829 and ZNF548

DIOPT Version :9

Sequence 1:	NP_652054.1	Gene:	CG17829 / 47718	FlyBaseID:	FBgn0025635	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	NP_001166244.1	Gene:	ZNF548 / 147694	HGNCID:	26561	Length:	545	Species:	Homo sapiens

Alignment Length:	491	Identity:	115/491 - (23%)
Similarity:	178/491 - (36%)	Gaps:	112/491 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SSVPAPQP--PGKRKKPAELELTCGWRDCQEICTGEWSLNGHIGDHLEHYAKAQDDRGAHAE--- 65
            |.|.|.:|  ..::..|:|   |||......:|..|     |.|.|.|.:...     ..||
Human    81 SEVTASKPCLSSQKVHPSE---TCGPPLKDILCLVE-----HNGIHPEQHIYI-----CEAELFQ 132

  Fly    66 HTEHQCTWNSCDFRTENQVEF--ERHSYYHGYYLNLLLQG-----KLECDLHPEIPACT-APARL 122
            |.:.|...|..  |.::.:..  :.|..:....:...::|     ...|.|..:.|... .|.|.
Human   133 HPKQQIGENLS--RGDDWIPSFGKNHRVHMAEEIFTCMEGWKDLPATSCLLQHQGPQSEWKPYRD 195

  Fly   123 MEKLPAL--GQN-FRCGWTDCEREFVSIVEFQDHIVKHA------------LFEYDI-----QKT 167
            .|...|.  ||| ::|  ::|.:.|.....|.:|...|.            .|:|..     |..
Human   196 TEDREAFQTGQNDYKC--SECGKTFTCSYSFVEHQKIHTGERSYECNKCGKFFKYSANFMKHQTV 258

  Fly   168 PEDERPKTMCNWAMCHKHMGNKYRLIEHISTHSNKKQVACFHCGELFRTKTTLFDHLRRQPENNT 232
            ...||... |.  .|.|.....|||:.|...|:.::...|..||:.||..:|...|.|  .....
Human   259 HTSERTYE-CR--ECGKSFMYNYRLMRHKRVHTGERPYECNTCGKFFRYSSTFVRHQR--VHTGE 318

  Fly   233 NSFQCAQCFKFFATKKLLKSH------------------------VVRHVNC------YKCTMCD 267
            ..::|.:|.|||.....|..|                        ::||...      |:|::|.
Human   319 RPYECRECGKFFMDSSTLIKHQRVHTGERPYKCNDCGKFFRYISTLIRHQRIHTGERPYECSVCG 383

  Fly   268 MTCSSASSLTTHIRYRHLKDKPLKCSECDTRCVRESDLAKHVQIVHSKTVHQCEHP----DCHYS 328
            ......|||..|.| .|..::|.|||||.      .....|.:::..:.||..|.|    :|...
Human   384 ELFRYNSSLVKHWR-NHTGERPYKCSECG------KSFRYHCRLIRHQRVHTGERPYECSECGKF 441

  Fly   329 VRTYTQMRRHFLEVHGNNPILYACHCCERFFKSGKSLS-AHLMKKHGFRLPSGHKRFTYRVDENG 392
            .|..:.:.:|:....|..|  |.|..|      ||:.| .|::.:|. ::.||.:.:.....:..
Human   442 FRYNSNLIKHWRNHTGERP--YECREC------GKAFSHKHILVEHQ-KIHSGERPYECSECQKA 497

  Fly   393 FYR----LETTRLESLEVTQQILSPQVNDSLAKPGT 424
            |.|    :...::.|.|  :.:.|..|.:||||..|
Human   498 FIRKSHLVHHQKIHSEE--RLVCSMNVGNSLAKTPT 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17829	NP_652054.1	C2H2 Zn finger	182..199	CDD:275368	6/16 (38%)
		C2H2 Zn finger	207..225	CDD:275368	7/17 (41%)
		C2H2 Zn finger	237..257	CDD:275368	7/43 (16%)
		C2H2 Zn finger	263..284	CDD:275368	7/20 (35%)
		C2H2 Zn finger	292..311	CDD:275368	5/18 (28%)
		C2H2 Zn finger	352..373	CDD:275368	6/21 (29%)
ZNF548	NP_001166244.1	KRAB	20..>60	CDD:214630
		KRAB	20..59	CDD:279668
		C2H2 Zn finger	211..231	CDD:275368	5/21 (24%)
		COG5048	<215..311	CDD:227381	23/98 (23%)
		C2H2 Zn finger	239..259	CDD:275368	3/19 (16%)
		C2H2 Zn finger	267..287	CDD:275368	7/21 (33%)
		zf-H2C2_2	280..304	CDD:290200	7/23 (30%)
		COG5048	<292..507	CDD:227381	54/232 (23%)
		C2H2 Zn finger	295..315	CDD:275368	8/21 (38%)
		zf-H2C2_2	310..330	CDD:290200	5/21 (24%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		zf-H2C2_2	336..360	CDD:290200	2/23 (9%)
		C2H2 Zn finger	351..371	CDD:275368	2/19 (11%)
		zf-H2C2_2	364..388	CDD:290200	5/23 (22%)
		C2H2 Zn finger	379..399	CDD:275368	7/20 (35%)
		zf-H2C2_2	391..416	CDD:290200	11/31 (35%)
		C2H2 Zn finger	407..427	CDD:275368	5/25 (20%)
		zf-H2C2_2	420..444	CDD:290200	5/23 (22%)
		C2H2 Zn finger	435..455	CDD:275368	3/19 (16%)
		zf-H2C2_2	447..472	CDD:290200	8/32 (25%)
		C2H2 Zn finger	463..483	CDD:275368	7/26 (27%)
		C2H2 Zn finger	491..511	CDD:275368	2/19 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910